Autoimmune thyroid diseases (ATD) are the most common organspecific autoimmune diseases with complex pathogenesis including the interaction between environmental, genetic, and immunological factors. 1 ATD comprise two main entities; Hashimoto's thyroiditis (HT) and Graves' disease (GD) which are considered the most common forms of ATD. Although, GD and HT usually have opposing clinical manifestations; hyperthyroidism and hypothyroidism, respectively, however, in line with a more flexible view of ATD, HT and GD can cause both hyperthyroidism and hypothyroidism, even alternating between one form and the other. 2 The hallmark of HT is the high rate of positivity of thyroglobulin and thyroid peroxidase antibodies (anti-TPO). 3 Moreover, high anti-TSH receptor antibody (TRAb) level is the mainstay in GD diagnosis. 4 The human microbiome consist of 100 trillion bacteria, protozoa, fungi, and viruses. It is of paramount importance in

Serum Heparin-binding protein serves as a non-invasive potential marker of acute bacterial meningitis even in partially treated cases.

BackgroundThe search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common & burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. MethodsSerum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy & 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. ResultsSigni cant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & 1.02, miRNA 27a showed 100%sensitivity, speci city, positive & negative predictive values. miRNA150-5p showed 88.89%sensitivity, 100%speci city, 100%positive and 78.9%negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was signi cantly associated with type I endometroid endometrial cancer. ConclusionWe suggest miRNA 27a and miRNA-150-5P as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.

It can make an impact on the different stages of cancer development (Jomova and Valko, 2011). It can alter the DNA sequence in the initiation step, increase cell division/ reduce apoptosis in the promotion stage and can also promote additional changes to the DNA in the progression

Background Anti-Müllerian hormone (AMH) is an important determinant of ovarian reserve in fertility workups in many clinical settings. Thus, we investigated the age dependent decline in AMH specific to the Egyptian population and sought to establish an age dependent reference interval parametrically. Methods Serum samples were collected from 841 apparently healthy women. AMH was measured using an electro-chemiluminescent technique. Box-Cox power transformation was used to make the AMH distribution Gaussian for parametric derivation of reference intervals. Results Power of 0.4 was found optimal for Gaussian transformation of AMH reference values. We demonstrate the strong negative relation between circulating AMH and female age with Spearman’s correlation coefficient of rS = −0.528. Age-specific reference interval was determined for every 5 years of age from 16 to 49, and nomogram was constructed by smoothing the lines connecting adjacent lower and upper reference limits. Conclusion The age-specific reference intervals and the age-AMH nomogram could be valuable in the clinical practice of in reproductive medicine. To our knowledge, this is the first study to confirm AMH levels in Egyptian females. We were able to explore age-related AMH levels specific to Egyptian females in the fertile age group and to treat skewed AMH data in a multi-step scheme using power transformation. Thus, a more accurate nomogram was constructed accommodating a profile delineated for a wide age range and a rescaled AMH axis improving its usability.