Assessment of serum uric acid levels in Type 2 diabetes mellitus patients

Sidhu, Gagandeep Kaur; Oza, Ruhan; Khubchandani, Asha; Prajapati, Bhavesh

doi:10.5455/ijmsph.2017.1027618102017

Cited by 4 publications

(3 citation statements)

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“…Likewise, hyperuricemia in DM is also shown by other various studies. 6,[22][23][24] Blood levels of Uric acid is also influenced by several factors such as overproduction, decreased glomerular filtration or renal hypoperfusion, enhanced tubular reabsorption or diminished elimination. 25 In our study raised level of SUA could be due to presence of high glucose concentration in blood resulting in tissue injury, which in turn leads to increased non protein substances that may accounts for increase uric acid levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

Dhungana

Pandeya

Pant

et al. 2022

JCMC

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Background: In spite of antioxidant property serum uric acid (SUA) has a positive association with blood glucose. SUA is considered as a strong and an independent risk factor for diabetes but low serum level of uric acid has been reported in the hyperglycemic state. Diabetes mellitus is a metabolic disorder of multiple etiologies resulting from defect in insulin action. So, aim of this study is to assess whether there is any change in SUA level and to establish whether there is any association with type II diabetes mellitus (DM) or not. Methods: A cross sectional study was conducted in 264 cases of DM. SUA, fasting blood glucose (FBG), post-prandial blood glucose (PPBG) and glycated hemoglobin (HbA1c) level were measured. Pearson’s correlation was employed to calculate the ‘r’ value by using SPSS version 15. Results: In our study prevalence of hyperuricemia was 18.5%. Mean SUA in male and female was 5.95 mg/dl and 5.54 mg/dl respectively in DM. HbA1c has positive correlation with FBG and PPBG (r value = 0.720 and 0.775, respectively p=<0.001), while SUA has negative correlation with HbA1c, FBG and PPBG (r value= -0.179, p =0.004, -0.070, p=0.257 and -0.078, p=-0.204 respectively.). Conclusions: SUA level is increased in DM. SUA was high among male and SUA initially increased when FBS and HbA1c increases then decreases as FBG and HbA1c level were further increased. SUA has negative correlation with FBG, PPBG and HbA1c, while HbA1c has a positive correlation with FBG and PPBG.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

Dhungana

Pandeya

Pant

et al. 2022

JCMC

View full text Add to dashboard Cite

show abstract

“…The levels of serum uric acid (SUA) are found to be elevated in diabetic patients. [49] The elevated SUA level acts as a key risk factor predicting diabetic-associated complications like stroke, kidney deterioration, and fatty liver disease, [50,51] necessitating SUA monitoring in diabetic patients in addition to glucose. The available at-home UA test kits like HumaSens plus and UASure require fingertip punctures, which hinders frequent UA measurement and…”

Section: In Vivo Ua and Glucose Detection In An Animal Model Of Diabetesmentioning

confidence: 99%

A Hydrogel Microneedle Assay Combined with Nucleic Acid Probes for On‐Site Detection of Small Molecules and Proteins

et al. 2023

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Point‐of‐care testing (POCT) of clinical biomarkers is critical to health monitoring and timely treatment, yet biosensing assays capable of detecting biomarkers without the need for costly external equipment and reagents are limited. Blood‐based assays are, specifically, challenging as blood collection is invasive and follow‐upprocessing is required. Here, we report a versatile assay that employs hydrogel microneedles (HMNs) to extract interstitial fluid (ISF), in a minimally invasive manner integrated with graphene oxide‐nucleic acid (GO.NA)‐based fluorescence biosensor to sense the biomarkers of interest in situ. The HMN‐GO.NA assay is supplemented with a portable detector, enabling a complete POCT procedure. Our system could successfully measure four clinically important biomarkers (glucose, uric acid (UA), insulin, and serotonin) ex vivo, in addition, to accurately detecting glucose and UA in vivo.

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“…Cell blood counts (CBCs), total iron-binding capacity (TIBC), transferrin, total iron, total protein, sodium, potassium, reticulocyte counts, and γglutamyl transferase (GGT) were determined according to [32; 34-36] 2.5.4. Kidney and liver functions Uric acid, urea, and creatinine were tested by the kit colorimetric enzyme assay according to [37]. Alkaline phosphatase (ALP), total bilirubin, albumin, glutamic pyruvic transaminase (GPT), and glutamic oxaloacetic transaminase (GOT) were done in serum according to [38].…”

Section: Serum and Hematology Analysesmentioning

confidence: 99%

Impact of Biscuit Fortified with Iron Nanoparticles as Food Supplement on Anemia in Albino Rat Model

et al. 2022

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Biscuits are favored products for people of different ages world-wide due to its high-energy foods, long shelf-life, and easy absorption. This study aimed to evaluate the fortified biscuit with iron nanoparticles (Fe2O3-NPs) as novel approach to overcome iron deficiency anemia (IDA) disease. In preliminary experiments, we utilized 4 groups of albino rats as follows; negative group (G1; control), positive group (G2), treated anemic group (G3), and untreated anemic group (G4). The SEM, XRD, histopathological, and hematology tests were performed. The results revealed that the Fe2O3-NPs was at 49.5±5 nm, homogenous, and purity. Fortified biscuits with Fe2O3-NPs increased the iron level (289±1.0 mg/dL), red blood counts (9.1±0.2 10 12 /L), and hemoglobin (18±0.25 g/dL) in the G3 compared to other groups. Histological examination showed that no significant effects on the spleen, kidney, and liver. Results demonstrated that the fortified biscuit with Fe2O3-NPs (10 ppm) at 49.5±5 nm is more effective in IDA treatment.

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Assessment of serum uric acid levels in Type 2 diabetes mellitus patients

Cited by 4 publications

References 0 publications

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

Evaluation of Serum Uric Acid, Glucose and Other Glycemic Parameter in Type Ii Diabetic Individuals

A Hydrogel Microneedle Assay Combined with Nucleic Acid Probes for On‐Site Detection of Small Molecules and Proteins

Impact of Biscuit Fortified with Iron Nanoparticles as Food Supplement on Anemia in Albino Rat Model

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