Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Hamdi, Rana Ali; Abdul-Qahar, Zina H.; Kadhum, Ekhlas J.; Alsaeed, Fatin A.

doi:10.32007/jfacmedbagdad.60212

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…The results of this research showed that PCOS patients had greater levels of fasting serum glucose, insulin, and HOMA-IR than controls, which is consistent with an earlier study from Iraq (18). The higher mean free testosterone level in the PCOS group as compared to control group is consistent with the findings of Rosenfield and Ehrmann indicating that PCOS women frequently have higher levels of total and free testosterone, which can prevent regular periods and fertilization even with a small increase (19).…”

Section: Discussionsupporting

confidence: 91%

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

2022

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Background: Polycystic ovary syndrome (PCOS) women's most prevalent endocrinology condition is a mixture of environmentally and genetically adduced causing PCOS. The relationship between monosaccharide and PCOS is largely unknown. Objective: This research was designed to investigate the relationship between blood levels of fructose, insulin resistance, and androgen hormone in women with PCOS, and the effect of obesity on the obtained result, as well as to study the efficacy of serum fructose as a biomarker in the diagnosis of PCOS. Cases and methods: This case-control research study was conducted at the Gynecology Clinic and Infertility Center, in Baghdad Teaching Hospital / Medical City between November 2021 to March 2022. It involved 120 women between the ages of 18-40 year. Fifty-nine women (cases) were newly diagnosed with PCOS by a gynecologist and 61 age and BMI matched healthy women (controls). PCOS women were subdivided according to their body mass index into four groups: lean, normal weight, overweight and obese. Investigations included serum measurements of fructose, luteinizing hormone (LH), follicular stimulating hormone (FSH), free testosterone, insulin, glucose, and calculated homeostasis model assessment- insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Results: The mean ±SD values of serum fructose, glucose, insulin and HOMA-IR were significantly augmented in PCOS women as compared to controls (p< 0.001), while mean value of QUICKI was significantly decreased (p<0.0001). There was a significant positive correlation between BMI values and fructose levels in PCOS women. The result showed that serum fructose and free testosterone levels had the highest sensitivity and specificity in the differentiation between the PCOS group and the controls, with the area under curve values for free testosterone higher than area under curve values for fructose. Conclusions: The fructose level can be used as an alternative biomarker for women with PCOS independent of insulin resistance. The majority of PCOS women are obese and overweight, and a minority are lean who are severely complicated by insulin resistance.

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Section: Discussionsupporting

confidence: 91%

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

2022

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“…Numerous scholars have documented a negative correlation between BMI and levels of vitamin D. A study from Egypt reported that although Vitamin D level was significantly reduced in women with PCOS compared to healthy women, no remarkable changes in Vitamin D levels were related to age group and BMI. 16 Kensara's study, after accounting for age and BMI as confounding variables, revealed a notable decrease in vitamin D levels among slender women afflicted with untreated PCOS compared to the control group. 17 Henceforth, in light of our investigations and the comprehensive examination of evidence, it can be posited that the diminishment of vitamin D in PCOS is not subject to direct influence by BMI.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Vitamin D deficiency in women with polycystic ovarian syndrome.

Bano,

Naz,

Ismail

et al. 2024

JSTMU

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Introduction: Approximately 20% of women who are of reproductive age suffer from the common endocrine illness known as polycystic ovarian syndrome, or PCOS. Vitamin D insufficiency is common among PCOS-affected women. The symptoms of PCOS seem to be regulated by the vitamin D pathway. According to studies, women with PCOS had high frequencies of vitamin D insufficiency, ranging from 65.0% to 70.3%. Thus, we aimed to discover how common vitamin D deficiency was in women diagnosed with PCOS. Methodology: This cross-sectional study was conducted at the Department of Obstetrics & Gynecology, CMH- Rawalpindi, from January to July 2022. A total of 90 women with polycystic ovarian syndrome diagnosed on Rotterdam criteria, 18 to 40 years of age, were included through a non-probability consecutive sampling technique. Pregnant female patients with chronic illnesses were excluded. After informed consent, data was collected from patients on a self-developed questionnaire. In all patients, a 3 ml blood sample was taken and sent to the institutional pathology laboratory to measure vitamin D levels. Results: The patients' average age was 28.91 ± 4.85 years—ages 18 to 30 comprised most of the 48 patients (53.33%). The average time a person had PCOS was 3.64 ± 1.58 years. The average body mass index was 29.02 ± 2.43 kg/m2. Forty-one (45.56%) of the PCOS patients had vitamin D insufficiency. Conclusion: As the frequency of vitamin D deficiency in women with PCOS is relatively high, we recommend that early identification through screening of the affected patients should be done.

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“…Despite the fact that anemia and vitamin D appear to be related ، the exact mechanism is unknown. However ، the majority of studies examining the relationship between renal anemia level ، vitamin D supplementation ، and deficiency emphasize the pervasive importance of inflammation in the underlying mechanisms (16) (17) .…”

Section: Introductionmentioning

confidence: 99%

Possible Effects of Vitamin D3 and Levofloxacin on Selected Hematology Parameter of Rats

Mhaibes,

Abdul- Wahab2

2023

IJPS

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Vitamin D is a fat-soluble vitamin with antioxidant and DNA protecting properties , Levofloxacin is a member of the fluoroquinolone drug class, Its broad-spectrum bactericidal effect affects both Gram-positive and Gram-negative bacteria. The goal of the study is to analyze the haematology analysis in rats received levofloxacin and show the preventive impact of vitamin D3 by analyzing the haematology parameters: packed cell volume (PCV), mean corpuscular hemoglobin concentration(MCHC),haemoglobin (HB), red blood cell (RBC), mean corpuscular volume (MCV),meancorpuscular haemoglobin(MCH), WBC ,differential WBC, and Platelets. The study included 42 rats divided into 6 groups each group 7 rats. group I negative control : healthy animals received normal saline 0.9%, group II: received levofloxacin LFX dose of 50mg/kg/day (IP) for fourteen days, group III : received LFX 100mg/kg/day (IP) for fourteen days, group IV : received vitamin D3 500 IU/day orally by oral gavage for twenty one days, group V received vitamin D3 500 IU/day orally for twenty one days and levofloxacin 50 mg/kg/day IP injected at day 8 for fourteen days, group VI received vitaminD3 500IU/day for twenty one days orally and levofloxacin 100 mg/kg/day IP injected at day 8 for fourteen days. Blood samples taken from rats treated with levofloxacin, showed a decrease in the values of RBC, HB, PCV, MCH, MCHC, as well as a decrease in total white blood cells, then returned approximately to normal levels in the groups IV ,group V and group VI . from the result of the study conclude that some haematological changes caused by levofloxacin ameliorated by vitamin D3 may be due to indirect effect of vitamin D3 on haematology parameters.

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Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Cited by 5 publications

References 10 publications

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity

Frequency of Vitamin D deficiency in women with polycystic ovarian syndrome.

Possible Effects of Vitamin D3 and Levofloxacin on Selected Hematology Parameter of Rats

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