Assessment of silver-coated urinary catheter toxicity by cell culture

Abstract

The toxicity of silver-coated urinary catheters was assessed using a cell culture technique. The inhibitory effect of catheter extracts on the uptake of 3H-labelled thymidine by mouse fibroblasts was measured. The results show that silver-coating had no toxic effect whereas silvernitrate and silversulphate coating did have a toxic effect.

Silver and its application as an antimicrobial agent

“…The toxic effect of silver in humans is low and attributed to the complexes or the salt used to deliver the silver [29]. The toxic effect of silver is well documented with in vitro studies of skin cells [30][31][32], and the results contradict the positive role of silver at wound sites [33]. Transitory acute leucopaenia has been reported on treatment of burn wounds patients with SSD [34], and the toxic effect was considered to be marginally significant.…”

“…There is no doubt that silver is efficacious in treating diverse dermatological infectious diseases, inflammation, and facilitating wound healing. The issue of silver toxicity in mammals is of concern based on in vitro studies of silver nitrate, silvadene and silver lactate [30][31][32].…”

A binuclear bis{bis(dimethylphosphino)methane}disilver(I) complex with weakly bonded hexafluoroacetylacetonato ligands

“…There has been recent interest in new methods of formation of silver films, which have potential applications as components of high-temperature superconducting materials (I), as contacts in microelectronic devices if problems of diffusion can be overcome (2), and as biocides in biomaterials used in appliances such as catheters (3). However, the formation of silver films by chemical vapour deposition (CVD) has proved to be difficult and the best precursors still have only borderline suitability for an effective CVD process (4,5).…”

Syntheses of Liquid Phase [(efac)Ag(P(OR)3)] Precursors and Their Application to the Preparation of Silver and Silver Selenide Thin Films

“…To this solution, 0.1 mol of sodium β-diketonate in 20 mL of THF was slowly added and the mixture was stirred for 2 hours. Then, a white precipitate of NaNO 3 was filtered off and after slow evaporation of solvent under vacuum, a brown-colored [(efac)Ag(P(OEt) 3 Silver and silver selenide thin films. Chemical vapor deposition experiments were carried out without H2 gas, using the above precursors in a glass warm-wall reactor on silicon [LG Siltron p-type (100)] or glass substrates as previously reported.…”