BackgroundThe objective of this study was to analyze the factors that can increase the possibility of mandibular canal (MC) defect in Chinese people, to evaluate the risk of nerve impairment, and to choose the proper operative method to reduce the risk of mandibular alveolar nerve injury during the extraction of mandibular third molar (MTM).Material/MethodsA total of 954 patients (1,304 MTMs) who underwent orthopantomography (OPG) and cone-beam computed tomography (CBCT) between July 2014 and December 2014 were included in this study. The age and gender of patients, impacted type (high impaction, moderate impaction, and low impaction), Winter classification of MTM, position of MTM relative to MC, vertical classification of MTM and MC, and the feature images of OPG were collected and compared to the imperfection of the MC wall in CBCT images.ResultsThe wall situation of MC was significantly correlated with the age of the patient, the depth of the molar, the position of the roots, and six imaging appearances on OPG. There was no significant difference based on gender.ConclusionsMost incomplete walls of MCs could be inferred by OPG. However, images based on CBCT could clarify the defect of the MC and also could clearly display the spatial relationship between the root and inferior alveolar canal.