Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera

Carneskog, Jan; Wadenvik, Hans; Fjälling, Martha; Kutti, Jack

doi:10.1111/j.1600-0609.1996.tb01335.x

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…Splenomegaly has been reported in 25-50 % of patients with ET (Carneskog et al, 1996). However Varghese reported splenomegaly in 19% of patients in there series which is somewhat analogous to our results (14.2%).…”

Section: Discussionsupporting

confidence: 90%

Clinico-Hematological Profile and Risk Stratification in Patients with Essential Thrombocythemia: Experience from Pakistan

Sultan

Irfan²,

Tanveer³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm characterized by sustained thrombocytosis and megakaryocytic hyperplasia. It is an uncommon hematological malignancy which primarily affects elderly individuals. The rational of this study was to determine its clinico-hematological profile along with risk stratification in Pakistan patients. Materials and Methods: In this retrospective cross sectional study, 21 patients with ET were enrolled from January 2011 to December 2014. Data was analyzed with SPSS version 21. Results: The mean age was 56.7±19.0 years (range 18-87) and the male to female ratio was 1:1.1. Of the total, 62% of patients were above 50 years of age. Overall 61.9% were diagnosed incidentally and were asymptomatic. In symptomatic patients, major complaints were weakness (19%); erythromelalgia (14.2%), transit ischemic attack (9.5%) and gastrointestinal bleed (4.7%). The mean hemoglobin count was 11.7±2.4 g/dl with a total leukocyte count of 13.3±8.1x10 9 /l and platelets count of 1188.8±522.2x10 9 /l. Serum lactate dehydrogenase, serum creatinine and uric acid were 454.3±127.8, 1.2±0.5 and 7.4±3.4 respectively. According to risk stratification, 57.1% were in high risk; 23.8% in intermediate risk while 19.1% in low risk group. Conclusions: ET in our patients in Pakistan, unlike in the West, is seen in a relatively young population. Primarily patients were asymptomatic and risk stratification revealed predominance of high risk disease in our setting.

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Section: Discussionsupporting

confidence: 90%

Clinico-Hematological Profile and Risk Stratification in Patients with Essential Thrombocythemia: Experience from Pakistan

Sultan

Irfan²,

Tanveer³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Alternatively, the raised amount of circulating stem cells and progenitor cells in peripheral blood could originate from sources other than the bone marrow, e.g. the enlargedspleen in PV (20) might be one such source. This assumption might find some support in the observation that 2 of the 4 patients with palpable splenomegaly demonstrated highly elevated numbers of CD34' cells in peripheral blood ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Increase of CD34 positive cells in polycythaemia vera

Andréasson

Swolin

Kutti

1997

European J of Haematology

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The purpose of the present work was to evaluate the proliferative character of polycythaemia vera (PV). Therefore, in 15 patients with different stages of PV we assessed the level of CD34 positive (CD34+) cells in peripheral blood and bone marrow, erythroid colony growth of bone marrow cells and plasma erythropoietin (EPO). The mean concentration of CD34+ cells in blood was significantly increased in PV patients (9.0±11.2×103/mL) compared to healthy controls (2.0±1.7×103/mL). In aspirated bone marrow no such difference between PV and control subjects was present. Six patients with splenomegaly and/or requirement for chemotherapy had significantly higher mean blood levels of CD34+ cells compared to the remaining PV patients. All PV patients presented EPO independent erythroid colonies. Three PV patients with anaemia and long disease duration had high EPO levels.

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“…They had all been referred to our unit because of elevated values for blood haemoglobin (Hb) concentration and/or PCV. In each case the diagnosis of PP was based upon a normal red cell mass as measured by 51Cr and a diminished plasma volume as measured by radioiodinated human serum albumin (ll), normal bone marrow histology as assessed from a biopsy obtained from the posterior iliac crest, and no splenomegaly as determined by gamma camera scintigraphy (12).…”

Section: Patientsmentioning

confidence: 99%

Plasma erythropoietin by high‐detectability immunoradiometric assay in untreated and treated patients with polycythaemia vera and essential thrombocythaemia

Carneskog

Kutti

Wadenvik

et al. 1998

European J of Haematology

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By using an immunoradiometric method with a stated detection limit of ≤1 IU/l (stated normal reference limit in adults 3.7–16 IU/l) we determined EDTA‐plasma erythropoietin (EPO) in 58 patients with polycythaemia vera (PV) and 49 patients with essential thrombocythaemia (ET). At the time of blood sampling, 20 of the PV patients were newly diagnosed and untreated, 23 were treated by phlebotomy only, and 30 also received myelosuppressive treatment (with 32P, hydroxyurea or alpha‐interferon). Of the ET patients 24 were untreated and 28 received myelosuppressive therapy. For comparison plasma EPO was also determined in 10 patients with pseudopolycythaemia (PP). In this latter group the results for plasma EPO agreed well with the cited normal reference limits. The majority of untreated PV patients (12/20) had undetectable plasma EPO concentration, and the remainder all had values below the lower normal reference limit. Plasma EPO in PV was not significantly influenced by phlebotomy therapy. Twelve of the 24 untreated ET patients (50%) had plasma EPO values below the reference interval (undetectable in 2 patients). The mean EPO concentration was significantly lower in PV patients receiving phlebotomy therapy than in patients with untreated ET. In the total material of PV and ET treated with myelosuppressive agents the PV patients showed significantly lower values for EPO concentration than did patients with ET. The present results support the view that EPO measurements by high‐detectability methods are diagnostically useful and should be included in the panel of new criteria for the diagnosis of PV.

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Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera

Cited by 17 publications

References 15 publications

Clinico-Hematological Profile and Risk Stratification in Patients with Essential Thrombocythemia: Experience from Pakistan

Clinico-Hematological Profile and Risk Stratification in Patients with Essential Thrombocythemia: Experience from Pakistan

Increase of CD34 positive cells in polycythaemia vera

Plasma erythropoietin by high‐detectability immunoradiometric assay in untreated and treated patients with polycythaemia vera and essential thrombocythaemia

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