Assessment of Subclinical Atherosclerosis by Epicardial Adipose Tissue and Aortic Intima-Media Thickness in Non-Alcoholic Fatty Pancreas Disease

Kul, Selim; Karadeniz, Ayşegül

doi:10.1016/j.amjcard.2018.03.042

Cited by 6 publications

(7 citation statements)

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“…The first documentation of atherosclerosis as a manifestation of fatty change of the pancreas can be traced back to autopsy studies conducted in the 1960s 35,36 . Recent clinical studies confirm this observation, where fatty change of the pancreas was associated with the thickening of epicardial adipose tissue and aortic intima‐media (markers of subclinical atherosclerosis) 37 . There have also been reports of a significantly increased carotid intima‐media thickness, 9,38 a higher prevalence of carotid artery plaque and vascular stiffness, 10,39 as well as coronary and carotid calcification in the presence of fatty change of the pancreas 40 .…”

Section: Discussionmentioning

confidence: 93%

“…35,36 Recent clinical studies confirm this observation, where fatty change of the pancreas was associated with the thickening of epicardial adipose tissue and aortic intimamedia (markers of subclinical atherosclerosis). 37 There have also been reports of a significantly increased carotid intima-media thickness, 9,38 a higher prevalence of carotid artery plaque and vascular stiffness, 10,39 as well as coronary and carotid calcification in the presence of fatty change of the pancreas. 40 Similarly, CGM metrics have been shown to be associated with cardiovascular pathologies.…”

Section: Discussionmentioning

confidence: 99%

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Intra‐pancreatic fat is associated with continuous glucose monitoring metrics

Liu,

Kimita,

Shamaitijiang

et al. 2024

Diabetes Obesity Metabolism

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AimTo investigate the relationship of fat in the pancreas with time spent in different glycaemic ranges.MethodsAbdominal magnetic resonance imaging at 3.0 Tesla was used to quantify fat in the pancreas as both continuous [i.e. intra‐pancreatic fat deposition (IPFD)] and binary (i.e. fatty change of the pancreas vs. normal pancreas) variables. Dexcom G6 devices were used to collect continuous glucose monitoring data every 5 min over a continuous 7‐day period. Time above range (TAR), time in range (TIR) and time below range were computed. Statistical models were built to adjust for age, sex, body composition, and other covariates in linear regression analysis and analysis of covariance.ResultsIn total, 38 individuals were studied. IPFD was significantly associated with TAR (p = .036) and TIR (p = .042) after adjustment for covariates. For every 1% increase in IPFD, there was a 0.3 unit increase in TAR and a decrease in TIR. Individuals with fatty change of the pancreas, when compared with those with normal pancreas, had significantly higher TAR (p = .034) and lower TIR (p = .047) after adjustment for covariates. Neither IPFD (p = .805) nor fatty change of the pancreas (p = .555) was associated with time below range after adjustment for covariates.ConclusionIncreased fat in the pancreas is associated with excessive glycaemic variability. Fatty change of the pancreas may contribute to heightening the risk of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Intra‐pancreatic fat is associated with continuous glucose monitoring metrics

Liu,

Kimita,

Shamaitijiang

et al. 2024

Diabetes Obesity Metabolism

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“…(n = 93, из них 44 больных с НАЖБПЖ, 49без нее) толщина эпикардиальной жировой ткани у пациентов с НАЖБПЖ была существенно выше: 6,09 ± 1,52 мм и 3,87 ± 1,31 мм соответственно; p < 0,001. У лиц с НАЖБПЖ также выявлена намного большая толщина комплекса интима-медиа аорты: 1,12 (0,60-1,90) мм и 0,93 (0,50-1,44) мм соответственно; p < 0,001 [22].…”

Section: связь с компонентами метаболического синдрома и сердечно-сос...unclassified

Metabolic aspects of fatty pancreatic disease

Mozgunova,

Semikova,

Khalimov

et al. 2024

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Aim. To update the understanding of non-alcoholic fatty pancreatic disease as an important component of the development and maintenance of metabolic syndrome, to present current data on the connection of this pathology with cardiovascular risks, and to outline approaches to diagnosis and treatment. Key points. Metabolic syndrome is one of the most common pathologies that significantly increases cardiovascular risks. It is known that excessive accumulation of lipids in the pancreas in patients with metabolic syndrome inevitably entails impaired functioning of beta cells. However, the term characterizing metabolic dysfunction of the pancreas against the background of its steatosis was introduced into circulation relatively recently. Thus, non-alcoholic fatty pancreatic disease acquires its own definitions that distinguish it from the traditional morphological approach, which consists more in assessing the content of the proportion of adipose tissue, but not the connection with the components of the metabolic syndrome. It is known that patients with non-alcoholic fatty pancreatic disease are more likely to have type 2 diabetes mellitus, arterial hypertension and atherosclerosis. Probably, the pathogenesis of its development is also closely related to non-alcoholic fatty liver disease. Conclusion. Non-alcoholic fatty pancreatic disease, being one of the key mechanisms of metabolic dysfunction, requires further research in order to determine preventive and therapeutic tactics. Keywords: insulin resistance, non-alcoholic fatty pancreatic disease, pancreatic steatosis, metabolic syndrome.

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“…Studies have also shown that FIP is linked with augmented epicardial adipose tissue and aortic intima-media thickness, which are markers of clinical atherosclerosis. FIP was strongly associated with a 3-fold increased risk of developing aortic intima-media thickness and a 16-fold increased risk of developing epicardial adipose tissue ( 105 ). Furthermore, FIP has been correlated with the severity of coronary artery stenosis in individuals with T2DM, suggesting that it may be a predictor of coronary artery stenosis in this population.…”

Section: Clinical Consequences Of Fipmentioning

confidence: 99%

Fatty infiltration of the pancreas: a systematic concept analysis

Mahyoub,

Elhoumed,

Maqul

et al. 2023

Front. Med.

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Fatty infiltration of the pancreas (FIP) has been recognized for nearly a century, yet many aspects of this condition remain unclear. Regular literature reviews on the diagnosis, consequences, and management of FIP are crucial. This review article highlights the various disorders for which FIP has been established as a risk factor, including type 2 diabetes mellitus (T2DM), pancreatitis, pancreatic fistula (PF), metabolic syndrome (MS), polycystic ovary syndrome (PCOS), and pancreatic duct adenocarcinoma (PDAC), as well as the new investigation tools. Given the interdisciplinary nature of FIP research, a broad range of healthcare specialists are involved. This review article covers key aspects of FIP, including nomenclature and definition of pancreatic fat infiltration, history and epidemiology, etiology and pathophysiology, clinical presentation and diagnosis, clinical consequences, and treatment. This review is presented in a detailed narrative format for accessibility to clinicians and medical students.

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Assessment of Subclinical Atherosclerosis by Epicardial Adipose Tissue and Aortic Intima-Media Thickness in Non-Alcoholic Fatty Pancreas Disease

Cited by 6 publications

References 0 publications

Intra‐pancreatic fat is associated with continuous glucose monitoring metrics

Intra‐pancreatic fat is associated with continuous glucose monitoring metrics

Metabolic aspects of fatty pancreatic disease

Fatty infiltration of the pancreas: a systematic concept analysis

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