The selection of materials for full-arch restorations remains a critical decision for clinicians, with ongoing debates surrounding the utilization of hybrid versus monolithic materials. This book chapter provides a comprehensive exploration of the considerations, challenges, and implications associated with these material choices. Beginning with an overview of historical and contemporary material landscapes, the chapter delves into the dynamic interplay between hybrid and monolithic materials, examining their respective compositions, clinical suitability, and long-term performance. Discussions encompass a range of factors including prosthetic space requirements, esthetic considerations, clinical challenges such as bruxism and temporomandibular joint issues, as well as patient-specific considerations such as age. Through comparative analyses, the chapter highlights the strengths and weaknesses of each material type, offering insights into their suitability for different clinical scenarios. The chapter concludes with a discussion on future trends and innovations, paving the way for continued advancements in full-arch restoration materials. Overall, this chapter aims to inform clinicians and researchers, facilitating informed decision making and enhancing patient outcomes in implant dentistry.