Assessment of Tamarindus indica Extracts for Antibacterial Activity

Nwodo, Uchechukwu U.; Obi-Iyeke, Grace E.; Chigor, Vincent N.; Okoh, Anthony I.

doi:10.3390/ijms12106385

Cited by 52 publications

(40 citation statements)

References 8 publications

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“…The ethanolic extract contains alkaloids and coumarins while aqueous extract does not contain alkaloids and coumarins as in line with the reported elsewhere [44] but differs in the detection of tannins and flavonoids (in aqueous leaves extract) which was found to be absent in all the extracts during the experiment. It is in agreement with Nwodo et al [45] but differs in glycosides and flavonoids which were found to be absent in aqueous leaves extract. Furthermore, Abukakar, et al [36] reported the presence of alkaloids in the aqueous leaves extract, but in contradiction, it was absent in this study.…”

Section: Phytochemical Screening Of T Indica Leaves Extractssupporting

confidence: 92%

Phytochemical Screening and Antiamebic Studies of Tamarindus Indica of Leaves Extract

Mehdi¹,

Alarabi²,

Farooqui

et al. 2019

Asian J Pharm Clin Res

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Objective: The present study deals with preliminary phytochemical screening of Tamarindus indica extracts and investigates its antiamebic effect against Entamoeba histolytica in vitro. Methods: E. histolytica was isolated from stools of patients with amebic dysentery and cultivated in lock-egg medium. The leaves extract was added to check its antiamebic activity. Results: The phytochemical screening shows that T. indica contains alkaloids, flavonoids, phenol, and tannins. T. indica extracts (aqueous and ethanolic) were added to culture media E. histolytica. It was observed that E. histolytica count reduced to zero after 72 h and 96 h when 15 mg/ml of aqueous and ethanolic extracts were added, respectively. It is also revealed that there is no cytotoxicity against erythrocytes even when high concentration of plant leaves extract is used. Conclusion: The in vitro sensitivity of T. indica leaves extract against the E. histolytica is established.

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Section: Phytochemical Screening Of T Indica Leaves Extractssupporting

confidence: 92%

Phytochemical Screening and Antiamebic Studies of Tamarindus Indica of Leaves Extract

Mehdi¹,

Alarabi²,

Farooqui

et al. 2019

Asian J Pharm Clin Res

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“…The seed polysaccharide of T. indica appears to be a potential promising candidate, as a vehicle for the topical treatment of bacterial keratitis (Ghelardi, ). The ethanolic extract that was hot and aqueous extract that was cold of fruit pulp, stem bark, and leaves of tamarind are of efficient use against the species of B. subtilis ATCC, P. aeruginosa , E. coli , and B. subtilis (Nwodo, Obiiyeke, Chigor, & Okoh, ).…”

Section: Health Perspectives Of Tamarindmentioning

confidence: 99%

“…The ethanolic extract that was hot and aqueous extract that was cold of fruit pulp, stem bark, and leaves of tamarind are of efficient use against the species of B. subtilis ATCC, P. aeruginosa, E. coli, and B. subtilis(Nwodo, Obiiyeke, Chigor, & Okoh, 2011).The alcoholic extract of T. indica seeds (200 µg/ml) exhibited the antibacterial activity against P. aerugnosia, E. coli, S. dysentery, S. typhi, Enteriococcus sp., S. auerus, and B. subtilus. The species S. typhi and E. coli were more susceptible to the seed extract when compared to other bacterial isolates with the inhibition zone up to 35 mm.…”

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confidence: 99%

RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

Arshad

Imran

Ahmed

et al. 2019

Food Science & Nutrition

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The modern‐day review article is an exquisite attempt to demonstrate the extreme therapeutic potential of tamarind fruit (Tamarindus indica), particularly its pulp, seed, and leaf extract, against lifestyle‐related chronic disorders. The rapid transition in the diet patterns and also the varying lifestyle of the people has made its way forth, a momentous upsurge in a number of chronic as well as degenerative diseases. An excess of foods having functional and nutraceutical significance has come into view recently. These foods have emerged as effective therapeutical remedies against these disorders owing to their natural phytochemical constituents present in them, in abundance. Tamarindus indica serves as a proverbial herbal medicine in each and every part of the world that is known to mankind. Also, the tamarind kernel powder (TKP) is of immense commercial significance in some of the major, leading industries of the World. The derivation of an important gel‐forming substance (polysaccharide), named as “jellose,” from the decorticated seed kernels of tamarind fruit has led to the manufacture of pectin. It is used in industrial scale in the preparation of various products like jams, jellies, and most important in the preparation of cheese. It plays an evident role as a stabilizer of commercial significance, and it has also been greatly recommend by the scientists to be used as a potent ingredient in a range of pharmaceutical products. The leaves of tamarind plant are also used as part of the daily diet in several countries where they are readily consumed in fresh form and especially during drought season.

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“…Situations where purification has led to loss of activity have been reported. Even not in all cases, fractionation of Tamarindus indica led to loss of activity to E. coli [23]. In the study of antifungal activity, demonstrated the lost activity in some medicinal plants after the separation of the plant extracts into precipitant and supernatant [24].…”

Section: Ic50 Cc50 and Si Of P Indicusmentioning

confidence: 99%

Antiviral Effect of Pterocarpus indicus Willd Leaves Extract Against Replication of Dengue Virus (DENV) In Vitro

Dewi

Angelina

Meilawati

et al. 2018

J.Trop.Life.Science

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Dengue hemorrhagic fever (DHF) is major public health problem in tropical and subtropical areas of the world with lack of approved vaccines and effective antiviral therapies. With no current treatment for illness attributed to dengue virus (DENV) infection other than supportive care, therapeutic strategies that use natural extract was developed.Indonesia have many plants that potential for antiviral drµgs such as Pterocarpus indicus Willd (P. indicus). The objective of this study was to determine the effect of P. indicus to inhibit DENV replication. We used a welldifferentiated hepatocytes-derived cellular carcinoma cell line (Huh-7 it-1 cells) to determine and select antiviral activity. The toxicity effects were determined by MTT assay. Then, the suppression of DENV replication was determined by Focus assay. Dengue infected cells with DMSO were used as control. We found that crude extract (Pi), hexane (Pi.1) and ethyl acetate (Pi.2) extract showed strong inhibition with high selectivity index (SI) of 1,392; 285.36 and 168.56 respectively. Sub fraction of Pi.1 and Pi.2 still showed strong inhibition with high SI. Further sub-sub fraction of Pi.2 such as Pi.2.12 and Pi.2.12.1 still showed inhibition of DENV replication but there was reduction of SI value. The mechanism experiment of Pi.2.12, we found that Pi 2.12 more profound to inhibit in the post infection stage that entry or pre-infection. We conclude that the sub-fraction of Pi.2.12 has potential antiviral activity against DV infection in vitro. Further studies are still needed to investigate the pure compound of Pi.2.12 that inhibit and have advantages in the future as alternative for treatment of DENV infection.

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Assessment of Tamarindus indica Extracts for Antibacterial Activity

Cited by 52 publications

References 8 publications

Phytochemical Screening and Antiamebic Studies of Tamarindus Indica of Leaves Extract

Phytochemical Screening and Antiamebic Studies of Tamarindus Indica of Leaves Extract

RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

Antiviral Effect of Pterocarpus indicus Willd Leaves Extract Against Replication of Dengue Virus (DENV) In Vitro

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