Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system

Chikukwa, Mellisa T R; Wesoły, Małgorzata; Korzeniowska, Aleksandra B; Ciosek-Skibińska, Patrycja; Walker, Roderick B.; Khamanga, Sandile M.

doi:10.1080/10837450.2019.1687520

Cited by 9 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is potential for scale-up production, however gastric permeability of HCTZ and long-term stability of these microparticles should be investigated first. Furthermore, it would be beneficial to evaluate the palatability of the microparticulate system using electronic taste sensing systems as a CQA for the target population as done in our previous studies [58].…”

Section: Discussionmentioning

confidence: 99%

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

Self Cite

View full text Add to dashboard Cite

Cardiovascular diseases such as hypertension and cardiac failure in South African children and adolescents are effectively managed long term, using a combination treatment of captopril and hydrochlorothiazide. The majority of commercially available pharmaceutical products are designed for adult patients and require extemporaneous manipulation, prior to administration to paediatric patients. There is a need to develop an age appropriate microparticulate dosing technology that is easy to swallow, dose and alter doses whilst overcoming the pharmacokinetic challenges of short half-life and biphasic pharmacokinetic disposition exhibited by hydrochlorothiazide and captopril. An emulsion solvent evaporation approach using different combinations of polymers was used to manufacture captopril and hydrochlorothiazide microparticles. Design of experiments was used to develop and analyse experimental data, and identifyoptimum formulation and process conditions for the preparation of the microparticles. Characterisation studies to establish encapsulation efficiency, in vitro release, shape, size and morphology of the microparticles were undertaken. The microparticles produced were in the micrometre size range, with an encapsulation efficiency >75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.

show abstract

Section: Discussionmentioning

confidence: 99%

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…IERs are widely used in wastewater treatment to remove contaminants like organic matter, heavy metals, dyes, and pharmaceutical waste [3]. They are also used in the pharmaceutical industry as a mechanism for taste masking; the taste of the pharmaceutical formulation plays an essential role in patient compliance [4]. Drugs that are bound to the IER are released only at a specific pH.…”

Section: Introductionmentioning

confidence: 99%

Ion Exchange Resins as Carriers for Sustained Drug Release

Kumar¹

2023

Ion Exchange Resins

View full text Add to dashboard Cite

Ion exchange resins are water-insoluble cross-linked polymers conventionally used in chemical engineering to separate and purify substances from fluid mixtures and for the separation of gases. They are used in the pharmaceutical industry as a carrier for controlled drug delivery systems. Sustained drug release involves the release of the drug at a predetermined rate into the target system and helps maintain a constant drug concentration for a specified period. At present ion-exchange resins are widely studied and used as drug-delivery agents. Ion-exchange fibers are shought as an alternative due to their better efficiency in drug loading and delivery.

show abstract

“…Recent progress and attempts were made on the oral sustained or controlled release formulation for metformin. Various methods are available to formulate water-soluble drugs into sustained release dosage forms by retarding the dissolution rate such as matrix tablets, coated tablets, floating tablets, slow release granules, sustained release oily matrix, sustained-release microparticles, and elementary osmotic pump [2][3][4][5][6]. For all these purposes, synthetic or natural polymers are used i.e.…”

Section: Introduction mentioning

confidence: 99%

In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation

Hariyanti

Erizal²,

Mustikarani

et al. 2022

Atom Indo.

View full text Add to dashboard Cite

The aim of this present work is to use polyvinyl alcohol (PVA)gelatin-based hydrogel prepared by γ-rays irradiation with different gelatin concentrations ranging from 0.5 -2 %w/v for immobilization of Metformin HCl (MH) at dose range of 0 -30 mg. The mixture were freezed-thawed for 3 cycles, irradiated using γ-rays with sterilization dose at 25 kGy (dose rates 5 kGy/h). Gel fraction and water absorption were determined gravimetrically. The surface morphology of hydrogels were observed using Scanning Electron Microscope (SEM). In vitro release of MH were taken using UV-Vis spectrophotometer. After evaluated, it was found that with increasing gelatin concentrations, gel fraction increases and water absorption decreases. With increasing gelatin concentration and drug dosage, the cumulative drug released decreases. From SEM observation, the hydrogel had a heterogeneous porous. The hydrogel based on PVA-gelatin can be considered as a matrix for controlled drug release and safe for humans since both PVA and gelatin are non-toxic.

show abstract

Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system

Cited by 9 publications

References 30 publications

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

Ion Exchange Resins as Carriers for Sustained Drug Release

In Vitro Release of Metformin HCl from Polyvinyl Alcohol (PVA) - Gelatin Hydrogels Prepared by Gamma Irradiation

Contact Info

Product

Resources

About