Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study

Verit, Ayhan; Savaş, Murat; Çiftçi, Halil; Aksoy, Nurten; Taşkın, Abdullah; Topal, Ufuk

doi:10.1038/ijir.2009.58

Cited by 21 publications

(20 citation statements)

References 29 publications

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“…Verit et al [30] confirmed that tadalafil revealed a beneficial effect on the cardiovascular system by reducing serum levels of oxidative stress. It has also been demonstrated that oral administration of tadalafil (10 mg/kg) 2 h before a 30-min coronary artery occlusion results in a smaller infarct size (42 8 2%) compared with vehicletreated animals (54 8 3%; p = 0.01).…”

Section: Discussionmentioning

confidence: 73%

The Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Rats

Guzeloglu

Yalçınkaya²,

Atmaca³

et al. 2010

Urol Int

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Acute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on renal injury in a renal I/R model in rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrectomy was performed, and the left renal pedicles were occluded for 60 min and reperfused for 60 min in the placebo and tadalafil groups. A single dose of tadalafil (10 mg/kg) through an orogastric tube was administered to the tadalafil group. Tubular atrophy with acute inflammation in renal histology, total oxidant status (TOS) and total antioxidant status (TAS) were determined in tissue homogenates. Compared to the tadalafil group, tubular atrophy and acute inflammation was significant in the placebo group. TAS levels were significantly higher in the tadalafil group compared to the placebo (p = 0.01) and sham groups (p = 0.04). While TOS levels were significantly higher in the placebo group (p = 0.03), tadalafil did not significantly alter the TOS levels. The beneficial effects of tadalafil can be attributed to its protective effects on renal tubular cells and inhibition of leukocyte infiltration in renal tissue. We think that tadalafil treatment has an important role in reducing renal injury resulting from renal I/R.

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Section: Discussionmentioning

confidence: 73%

The Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Rats

Guzeloglu

Yalçınkaya²,

Atmaca³

et al. 2010

Urol Int

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“…At peak blood levels following administration of 20 mg of tadalafil to men with ED, serum antioxidants rose 45%, serum oxidants declined 33% and serum paraoxonase-1 activity increased 50% (Figure 4, all Po0.0001). 68 The magnitude of increase of PON-1 was great enough to reverse the reduction of PON-1 observed in men with ED (inset, Figure 4). 3 This same dose given to men with cardiovascular risk factors caused a greater than twofold increase of FMD at the end of 4 weeks and continuing for 2 weeks after cessation of tadalafil (both Po0.01), whereas no changes were observed with placebo.…”

Section: Other Factorsmentioning

confidence: 88%

“…Further randomized trials are needed, Figure 4 In men with cardiovascular risk factors at 2 h after 20 mg of tadalafil, total serum antioxidant status (TAS) increased 45%, total serum oxidant status (TOS) decreased 33% and serum PON-1 activity increased 50% (all Po0.0001). 68 Inset: PON-1 activity was significantly decreased in men with ED (Po0.001). 3 Lifestyle, metabolism and erectile function DR Meldrum et al including various combinations of the listed interventions, 50 such as the favorable effects on ED of combining testosterone and sildenafil, 36 or of the Mediterranean diet, which increases intakes of omega-3's, antioxidants and folic acid.…”

Section: Reduction Of Inflammation Improves Endothelial Function and Edmentioning

confidence: 98%

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been linked to abdominal obesity, smoking and high intakes of fat and sugar, which all cause oxidative stress. Men with ED have decreased vascular NO and circulating and cellular antioxidants. Oxidative stress and inflammatory markers are increased in men with ED, and all increase with age. Exercise increases vascular NO, and more frequent erections are correlated with decreased ED, both in part due to stimulation of endothelial NO production by shear stress. Exercise and weight loss increase insulin sensitivity and endothelial NO production. Potent antioxidants or high doses of weaker antioxidants increase vascular NO and improve vascular and erectile function. Antioxidants may be particularly important in men with ED who smoke, are obese or have diabetes. Omega-3 fatty acids reduce inflammatory markers, decrease cardiac death and increase endothelial NO production, and are therefore critical for men with ED who are under age 60 years, and/or have diabetes, hypertension or coronary artery disease, who are at increased risk of serious or even fatal cardiac events. Phosphodiesterase inhibitors have recently been shown to improve antioxidant status and NO production and allow more frequent and sustained penile exercise. Some angiotensin II receptor blockers decrease oxidative stress and improve vascular and erectile function and are therefore preferred choices for lowering blood pressure in men with ED. Lifestyle modifications, including physical and penile-specific exercise, weight loss, omega-3 and folic acid supplements, reduced intakes of fat and sugar, and improved antioxidant status through diet and/or supplements should be integrated into any comprehensive approach to maximizing erectile function, resulting in greater overall success and patient satisfaction, as well as improved vascular health and longevity.

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“…Pharmacology attenuate doxorubicin-induced cardiotoxicity in patients [8], ischaemic/reperfusion injury in rat ovary [9] and decrease oxidative stress in erectile dysfunction in men [10]. Here, we report antioxidant and anti-inflammatory action of tadalafil in pulmonary hypertension induced by chronic hypobaric hypoxia in rat.…”

Section: Fundamental and Clinicalmentioning

confidence: 72%

Efficacy of tadalafil in chronic hypobaric hypoxia–induced pulmonary hypertension: possible mechanisms

Rashid

Fahim

Kotwani

2012

Fundamemntal Clinical Pharma

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The present study was carried out to investigate the effects of long-acting phosphodiesterase five inhibitor, tadalafil, on pulmonary hypertension induced by chronic hypobaric hypoxia in rats. Adult Albino Wistar rats were exposed to 2 weeks of hypobaric hypoxia for 8 h daily and treated with tadalafil or tempol, a standard antioxidant agent. Right ventricular systolic pressure (RVSP) was taken as an index for pulmonary arterial pressure; malondialdehyde, reduced glutathione and superoxide dismutase were chosen as the markers of oxidative stress; serum tumour necrosis factor alpha (TNF-α) levels and inflammatory changes in lungs were assessed for inflammation. Chronic hypobaric hypoxia was found to induce pulmonary hypertension, as it significantly (P < 0.001) increased RVSP. Chronic hypobaric hypoxia also leads to an increase in oxidative stress as was evidenced by an increase in malondialdehyde levels (P < 0.001) and a significant decrease in (P < 0.001) reduced glutathione levels and superoxide dismutase activity. Chronic hypobaric hypoxia-induced inflammation was revealed by lung histology and increase in serum TNF-α levels. Tadalafil significantly prevented (P < 0.001) rise in hypobaric hypoxia-induced rise in RVSP. Tadalafil partially while tempol completely reversed hypobaric hypoxia-induced oxidative stress. Lung inflammation and serum TNF-α levels were significantly attenuated by both tadalafil and tempol. However, effect of tadalafil on inflammation was more marked than that of tempol. These data indicate that tadalafil possess antioxidant as well as antinflammatory action in addition to its vasodilatory property. All these three actions combined may have positive impact of tadalafil in the treatment of hypobaric hypoxia-induced pulmonary hypertension.

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Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study

Cited by 21 publications

References 29 publications

The Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Rats

The Beneficial Effects of Tadalafil on Renal Ischemia-Reperfusion Injury in Rats

Lifestyle and metabolic approaches to maximizing erectile and vascular health

Efficacy of tadalafil in chronic hypobaric hypoxia–induced pulmonary hypertension: possible mechanisms

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