Assessment of the anti‐feeding and insecticidal effects of the combination of dinotefuran, permethrin and pyriproxyfen (Vectra^®3D) againstTriatoma infestanson rats

Abstract

Abstract. This study, based on the rat model, was designed to explore the anti-feeding and insecticidal efficacy of a topical ectoparasiticide, dinotefuranpermethrin-pyriproxyfen (DPP), against Triatoma infestans (Hemiptera: Reduviidae), a vector of Trypanosoma cruzi (Trypanosomatida: Trypanosomatidae), for which dogs are domestic reservoir hosts. Twenty rats were divided into two equal groups: untreated and treated. Each rat was exposed under sedation to 16 T. infestans of mixed life stages for 1 h on days 1, 7, 14, 21 and 28 post-treatment. The anti-feeding and insecticidal effects of DPP were estimated after 1 h of exposure. Insecticidal efficacy was also assessed after incubation of the insects for 24 h post-exposure. Anti-feeding efficacy was 96.7, 84.7, 80.5, 81.5 and 42.6% on days 1, 7, 14, 21 and 28, respectively. Insecticidal efficacy evaluated at 1 and 24 h after exposure on days 1, 7, 14, 21 and 28 was 100, 91.2, 82.5, 80.0 and 29.1, and 100, 100, 100, 96.0 and 49.9%, respectively. This study demonstrates that a single administration of DPP spot-on treatment at a dose equivalent to the minimal recommended dose in rats has a powerful effect against T. infestans starting from day 1 that lasts for at least 3 weeks.

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

“…This approach has been registered to provide broad-spectrum activity against nematodes and ectoparasites in dogs [7,18,19]. In addition, the separate use of Vectra ® 3D (dinotefuran-permethrin-pyriproxyfen) and Milbactor ® (milbemycin oxime/praziquantel) have been proven to be effective against a wide range of vectors and Dirofilaria larvae [20][21][22][23][24], leading to a reinforcement of their synergetic effect against Dirofilaria transmission when administrated concomitantly.…”