Background Globally, maternal morbidity and mortality a major public health challenge. Uterine rupture is a life-threatening obstetrical emergency with serious undesired complications for both the mother and her infant. Uterine rupture is the leading cause of maternal and fetal death in developing countries. Therefore, the aim of this systematic review and meta-analysis was to assess the prevalence of uterine rupture and its associated factors in Ethiopia. Method: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. The databases used were; PubMed, Google scholar, Cochrane Library, African Journals Online, Ethiopian's university research repository online library, and manual searching. The search was further limited to studies conducted in Ethiopia and reported in English. Two authors independently extracted all necessary data using a standardized data extraction format. STATA 11 software was used to analyze the data. The Cochrane Q and I2 test were used to assess the heterogeneity of studies. The pooled estimate prevalence and the odds ratios with 95% confidence intervals were computed by a random effect model. Result: A total of 16 studies were included in this meta-analysis with a sample size of 10,550. The national pooled prevalence of uterine rupture was 14.74%. The pooled adjusted odds ratio (AOR) of uterine rupture for prolonged labour(>24hours) was 4.3 (95% CI=2.57,7.19), not having antenatal care during pregnancy was 3.71(95%CI=2.26,6.08),grand multiparity was 1.99(95%CI=1.04,3.81),rural residency was 4.17 (95%CI=1.72,10.12),having cesarean section scar was 8.52 (95%CI: 4.98,14.59),not using partograph during labour was 3.43(1.62,7.29), and obstructed labour was 8.78(95%CI:3.38,22.8). Conclusion: This systematic review and meta-analysis showed that uterine rupture was high in Ethiopia. Being from the rural residence, prolonged labour(>24hours) , not having ante natal care , grand multiparity, having cesarean section scar , not using partograph during labour, and obstructed labour increased the risk of uterine rupture.