Assessment of the duration of maternal‐derived antibodies specific to the Mycoplasma agalactiae vaccine in goat kids

Abstract

Background Contagious agalactia (CA) is one of the most important diseases in the small ruminant industry in Iran. The historical aetiology of this disease is Mycoplasma agalactiae (Ma). The main way to control this disease, in addition to management measures, is vaccination. In ruminant newborns, determining the age of first vaccination against Ma is a challenge due to the interference between colostrum‐derived maternal immunity and vaccination‐induced immunity. The aim of this study was to evaluate the consistency of maternal‐derived antibodies specific to the Ma in goat kids blood serum born from the vaccinated does. Objectives Dtermination of level of antibody against Ma in goat kids born from vaccinated dams against Ma. Assessment of duration of protective level of maternal derived antibody in goat kids serum, after receiving colostrum from vaccinted mother with Ma vaccine. Determination the best time vaccination against Ma in goat kids receiving colostrum from vaccinated dams. Methods 20 Saanen goat kids were studied in two groups of 10 animals including control (receiving colostrum from unvaccinated does) and treatment (receiving colostrum from vaccinated does). Indirect Elisa was used to evaluate serum specific antibodies to Ma in goat kids (control and treatment groups) from birth to 100 days of age. Results After receiving a sufficient amount of colostrum, the goat kids in the treatment group had a significantly higher S/P% than the control group until 56 days after birth (p < 0.05) and at 70–100 days after birth, there was no significant difference between the treatment and control groups (p > 0.05). Conclusions This study showed that 56–70 days of age could be a good age to give the first dose of CA vaccine in goat kids, but more studies are needed on the effectiveness of this vaccine at this age.

Determining the decreasing trend of maternal immunity against small ruminant morbillivirus in goat kids

“…PPR is one of the most important viral diseases in sheep and goats (Bazarghani et al., 2006 ). Currently, one of the most important issues in the small ruminant breeding industry in Iran is determining the appropriate age for the first vaccination of neonates against important infectious diseases (Abdollahi et al., 2022 ).…”

“…Inclusion criteria were determined for mothers (complete clinical health, singleton pregnancy, having a good BCS [3 on the 5‐point scale]) and for kids (complete clinical health, delivery without intervention, appropriate weight) (Abdollahi et al., 2022 ; Vries et al., 2014 ).…”

“…Exclusion criteria were determined for mothers (disease incidence) and for kids (FPT, disease incidence) (Abdollahi et al., 2022 ; Vries et al., 2014 ).…”

“…and for kids (complete clinical health, delivery without intervention, appropriate weight) (Abdollahi et al, 2022;Vries et al, 2014).…”

“…in the small ruminant breeding industry in Iran is determining the appropriate age for the first vaccination of neonates against important infectious diseases(Abdollahi et al, 2022).Studied vaccine caused the positive serum VN ability in all vaccinated female goats. This positive serum VN ability was stable for 6 months (until delivery).…”