Assessment of the effect of long-term continuous stay in the artificial hypoxic gas-air environment at normal atmospheric pressure on the functional state of the cardiovascular system

It is believed that hypoxia-induced factor (HIF1) is the key mediator of oxygen metabolism. It was first identified as a transcription factor activated in cells and tissues by lowering the partial pressure of oxygen (O2). The HIF1 activator spectrum includes both external factors hypoxia, psycho-emotional stress and in ternal factors and varies from hormones to iron chelators. This review is dedicated to the molecular mechanisms of HIF1 activation, some of its natural activators HIF1, the potential for which is due to the low level of toxicity and the reduced likelihood of undesirable side effects. In turn, this opens up new options to treat diseases associated with local and general ischemia and hypoxia, the possibilities of their prophylactic use for researchers and clinicians in order to reduce the degree of damage in the event of an unforeseen condition of acute injurious to organs and tissues by hypoxia and reperfusion after it.

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Mechanisms and triggers of adaptation to hypoxia

Lyubimov

Владимирович²,

Черкашин

et al. 2021

Rev Clin Pharm Drug Ther

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A promising method for the diagnosis of preclinical hypoxic state

Lyubimov

Khokhlov²,

Bychkov³

et al. 2022

Rev Clin Pharm Drug Ther

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BACKGROUND: The state of hypoxia in natural conditions occurs in certain cases and is considered as a negative process in the overwhelming majority of cases. However, exogenous hypoxia is used as a factor of adaptation / preconditioning and training to the forthcoming hypoxic stress under some conditions, as well as increasing physical endurance and working capacity in normoxic conditions among specialists of various profiles. The mechanisms of adaptation to exogenous hypoxia have been studied in detail. Earlier in our studies, the value of artificial exogenous normobaric hypoxic hypoxia, which does not have a negative effect on the human body, was determined. AIM: The aim of this work was to determine hypoxia inducible factor 1 (HIF-1) as a possible marker of adaptation to normobaric hypoxic hypoxia. MATERIALS AND METHODS: For 100 days, 6 test volunteers were continuously in a sealed residential test room based on the test bench of ASM JSC (St. Petersburg) in a state of normobaric hypoxic hypoxia (oxygen content 1220%). RESULTS: No clinically significant erythrocyte response to long-term exposure to normobaric hypoxic respiratory mixture was expectedly detected, although statistically significant fluctuations in the level of hemoglobin and the absolute number of erythrocytes were determined. When analyzing the HIF-1 concentration, qualitative data were obtained, characterizing a significant response (p 0.05) in the change in HIF-1 concentration during the observation period. Additionally, a Kendall consistency factor of 0.68 was calculated, suggesting a significant difference in HIF-1 concentration dynamics. CONCLUSIONS: The chosen mode of hypoxia can be used as a method of exogenous preconditioning.

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The molecular marker of the preconditioning phenomenon HIF1α is a new pathway for early detection of visceral hypoxic conditions

Черкашин

Викторович²,

Lyubimov

et al. 2020

Terapevticheskii arkhiv

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Improvement and development of technologies for laboratory and instrumental examination of patients in recent years have greatly facilitated the diagnosis of ischemic myocardial damage. However, a decrease in the rating of cardiovascular diseases is not expected in the short term. This is due to an increase in the life expectancy of the population, general aging of the population and improving diagnostic capabilities and the provision of medical care. The time for verification of the diagnosis of ischemic disease, simplified the decision on treatment tactics were significantly reduced by introduction of X-ray contrast visualization examination methods such as angiography, quantitative and qualitative laboratory tests, development of diagnostic criteria based on the results of ultrasound and electrophysiological examination methods. Unfortunately, all these techniques are secondary in nature and are applied, when organ damage is for the most part already irreversible. Full restoration of organs is possible only if the patient is successfully evacuated to the hospital and there are specialists of the appropriate level of experiebce, X-ray surgical equipment with suitable supplies or pharmacological agents, usefull for quickly restoration the patency of the great vessels and normal blood flow. A large number of studies appear on the phenomenon of preconditioning at the present stage of development of fundamental medical science. The purpose of this article is to reveal the possibilities of using molecular markers of the phenomenon of preconditioning in the framework of the early detection of hypoxic conditions, the assessment of their diagnostic use in the clinic and the prevention of hypoxia-associated diseases.

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Assessment of the effect of long-term continuous stay in the artificial hypoxic gas-air environment at normal atmospheric pressure on the functional state of the cardiovascular system

Cited by 3 publications

References 10 publications

Mechanisms and triggers of adaptation to hypoxia

Mechanisms and triggers of adaptation to hypoxia

A promising method for the diagnosis of preclinical hypoxic state

The molecular marker of the preconditioning phenomenon HIF1α is a new pathway for early detection of visceral hypoxic conditions

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