Assessment of the environmental toxicity and carcinogenicity of tungsten-based shot,

Thomas, Vernon G.; Roberts, Michael J.; Harrison, Paul

doi:10.1016/j.ecoenv.2009.01.001

Cited by 25 publications

(14 citation statements)

References 49 publications

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“…This long-term exposure could increase the risk of cancer development in injured individuals. Moreover, leakage of metal solutions to drinking water and soil because of some environmental contaminants may also increase metal exposure in the general population (Clausen and Korte, 2009;Thomas et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Verma¹,

Xu²,

Jaiswal³

et al. 2011

Toxicology and Applied Pharmacology

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In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components" (2011 Tungsten-alloy has carcinogenic potential as demonstrated by cancer development in rats with intramuscular implanted tungsten-alloy pellets. This suggests a potential involvement of epigenetic events previously implicated as environmental triggers of cancer. Here, we tested metal induced cytotoxicity and epigenetic modifications including H3 acetylation, H3-Ser10 phosphorylation and H3-K4 trimethylation. We exposed human embryonic kidney (HEK293), human neuroepithelioma (SKNMC), and mouse myoblast (C2C12) cultures for 1-day and hippocampal primary neuronal cultures for 1-week to 50-200 μg/ml of tungsten-alloy (91% tungsten/6% nickel/3% cobalt), tungsten, nickel, and cobalt. We also examined the potential role of intracellular calcium in metal mediated histone modifications by addition of calcium channel blockers/chelators to the metal solutions. Tungsten and its alloy showed cytotoxicity at concentrations N 50 μg/ml, while we found significant toxicity with cobalt and nickel for most tested concentrations. Diverse cell-specific toxic effects were observed, with C2C12 being relatively resistant to tungsten-alloy mediated toxic impact. Tungsten-alloy, but not tungsten, caused almost complete dephosphorylation of H3-Ser10 in C2C12 and hippocampal primary neuronal cultures with H3-hypoacetylation in C2C12. Dramatic H3-Ser10 dephosphorylation was found in all cobalt treated cultures with a decrease in H3 pan-acetylation in C2C12, SKNMC and HEK293. Trimethylation of H3-K4 was not affected. Both tungsten-alloy and cobalt mediated H3-Ser10 dephosphorylation were reversed with BAPTA-AM, highlighting the role of intracellular calcium, confirmed with 2-photon calcium imaging. In summary, our results for the first time reveal epigenetic modifications triggered by tungsten-alloy exposure in C2C12 and hippocampal primary neuronal cultures suggesting the underlying synergistic effects of tungsten, nickel and cobalt mediated by changes in intracellular calcium homeostasis and buffering.Published by Elsevier Inc.

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Section: Discussionmentioning

confidence: 99%

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Verma¹,

Xu²,

Jaiswal³

et al. 2011

Toxicology and Applied Pharmacology

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“…Knowledge regarding the effects of tungsten in the soil, on its transfer in the food chain, and thus on human health is still incomplete [1]. In some cases, tungsten has been found to be nontoxic and substantially inert in the soil [12], whereas in other studies, very negative hypotheses have been put forward on the possible action of tungsten in the formation of neoplasms in animal cells [7]. The growing interest in this element is further highlighted by several studies on the impact of W on soil microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Influence of Increasing Tungsten Concentrations and Soil Characteristics on Plant Uptake: Greenhouse Experiments with Zea mays

Petruzzelli¹,

Pedron²

2019

Applied Sciences

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Tungsten is largely used in high-tech and military industries. Soils are increasingly enriched in this element, and its transfer in the food chain is an issue of great interest. This study evaluated the influence of soil characteristics on tungsten uptake by Zea mays grown on three soils, spiked with increasing tungsten concentrations. The soils, classified as Histosol, Vertisol, and Fluvisol, are characteristic of the Mediterranean area. The uptake of the element by Zea mays was strictly dependent on the soil characteristics. As the pH of soils increases, tungsten concentrations in the roots and shoots of the plants increased. Also, humic substances showed a great influence on tungsten uptake, which decreased with increasing organic matter of soils. Tungsten uptake by Zea mays can be described by a Freundlich-like equation. This soil-to-plant transfer model may be useful in promoting environmental regulations on the hazards of this element in the environment.

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“…This huge amount of W is generally used for tungsten-cemented carbide, metal wires, turbine blades, high temperature lubricants, incandescent lamp filaments, television sets, heat sinks, golf clubs, fishing weights, and hunting ammunitions (Koutsospyros et al, 2006). Toxicity of the lead (Pb) bullets triggered the use of W as a low caliber ammunition as well (Fisher et al, 2006;Thomas et al, 2009). In addition to the industrial and domestic uses, dissolution of W-bearing minerals was found to be another major source for the occurrence of W (VI) in the environment (Seiler et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Influence of phosphate on tungstate sorption on hematite: A macroscopic and spectroscopic evaluation of the mechanism

2018

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Environmental fate of tungstate (VI) oxyanion [i.e. mono tungstate and several polytungstate, generally expressed by W (VI)] is largely controlled by sorption on soil minerals, especially on iron oxide minerals. Molecular scale evaluation of W (VI) retention on iron oxides in the presence of competing oxyanions is scarce in the literature. Here we report surface interaction mechanisms of W (VI) on hematite in the presence of phosphorus (P) using macroscopic and in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic experiments. Batch sorption experiments were conducted using 2g L-1 hematite and 100 µM W (VI) and P, in single ion system and in binary mixtures as a function of pH (4-11). In situ ATR-FTIR spectroscopic evaluation of P and W (VI) sorption on hematite was also carried out. The results from macroscopic experiments indicated that W (VI) sorption on hematite was not affected when W (VI) was added first. The influence of P on W (VI) sorption was noticed when W (VI) & P were added simultaneously or P was added first. The in situ ATR-FTIR spectroscopic data corroborated this finding. In addition, the spectroscopic data revealed that in the presence of P, surface complexation mode of W (VI) differed as noted from either the absence of W-O antisymmetric infrared (IR) band or the W-O-W stretching band. This study provides useful information on molecular level understanding of W (VI) surface complexation on hematite in the presence of competing ions such as P.

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Assessment of the environmental toxicity and carcinogenicity of tungsten-based shot,

Cited by 25 publications

References 49 publications

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Influence of Increasing Tungsten Concentrations and Soil Characteristics on Plant Uptake: Greenhouse Experiments with Zea mays

Influence of phosphate on tungstate sorption on hematite: A macroscopic and spectroscopic evaluation of the mechanism

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