Assessment of the feed additive consisting of naringin for all animal species for the renewal of its authorisation (HealthTech Bio Actives, S.L.U. (HTBA))

Abstract

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for the renewal of authorisation of naringin as a sensory additive for all animal species. The applicant provided data demonstrating that the additive currently in the market complies with the conditions of authorisation. The FEEDAP Panel confirms that the use of naringin under the current authorised conditions of use is safe for the target species, the consumers and the environment. Naringin does not cause severe irritation or corrosion to eyes, is not irritant to the skin and is not classified as a dermal sensitiser. The FEEDAP Panel cannot conclude on the possible respiratory sensitisation of the additive, due to the lack of data. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis

“…Several studies have screened many active metabolites from Chinese herbal plants; flavonoids comprise a significant category. In terms of avoiding adverse drug reactions, citrus bioflavonoids seem to be safe, without causing side effects even during pregnancy; naringin-derived drugs are used in traditional medicine because of their non-addictive and non-toxic properties ( Bampidis et al, 2022 ); isoflavones not only help reduce the risk of breast and endometrial cancer but also alleviate hot flushes associated with menopause ( Gómez-Zorita et al, 2020 ). Yong et al (2021) conducted a double-blind experiment on 58 healthy postmenopausal women, administering a daily dose of Epimedium prenylflavonoid extract (740 mg) or a placebo for 6 weeks.…”