Assessment of the feeding arteries by three-dimensional computed tomography angiography prior to multi-arterial infusion chemotherapy for lung cancer

Abstract

Abstract. The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with non-small cell lung cancer underwent MDCT angiography of the thorax prior to multi-arterial infusion for lung cancer. Findings on CT angiograms, including CT scans, maximum intensity projections and three-dimensional volume-rendered images, were used to evaluate the depiction of bronchial and non-bronchial systemic arteries. The results of detecting the feeding arteries for lung cancer by MDCT angiography and conventional angiography were compared. Among the 59 patients treated with multi-arterial infusion chemotherapy, a total of 80 feeding arteries (62 bronchial feeding arteries and 18 non-bronchial systemic arteries) were detected by conventional angiography and/or MDCT angiography. In 56 (70%) feeding arteries (including 44 bronchial feeding arteries and 12 non-bronchial systemic arteries) for lung cancers, concordant findings were observed with the two modalities. In 23 (29%) cases, MDCT angiography could not be used to define feeding arteries, but was used to identify the ostia of these feeding arteries. In one (1/80, 1.3%) case, the CT-defined feeding artery was not selectively catheterized. MDCT angiography of the chest is able to provide an overview for successful catheterization in multi-arterial infusion chemotherapy for lung cancer.

Concurrent Bronchial Artery and Posterior Inferior Cerebellar Artery Microcatheter Interventional Chemotherapy for Adenocarcinoma of the Lung with Solitary Cerebellar Metastasis

“…Therefore, when the injection pressure is high, or the injection speed is fast, complications may arise that include paraplegia [11]. Therefore, superselective perfusion with microcatheters can be used to avoid spinal cord injury [12–14]. However, it is difficult for some patients to have microcatheters sited during the treatment procedure.…”

Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer

“…As a consequence, adjuvant chemotherapy, notably bronchial arterial infusion (BAI), becomes a major approach for clinical treatment for lung cancer. BAI can directly infuse high-concentration chemotherapeutic agents into tumor tissues, thereby reducing tumor size, improving clinical symptoms, and decreasing the incidence of adverse effects [4]. However, the natural or emergence of insensitivity to chemotherapeutic drugs in lung cancer during treatment, namely chemotherapy resistance, leads to substantially increased failure rates in the treatment for lung cancer, with a total efficacy rate of 40–60 % [5–7].…”