Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts

Potential Genotoxic and Cytotoxic Effects of Plant Extracts

“…The data presented here show that the P. granatum L. fruit www.intechopen.com hydroalcoholic extract can induce genetic damage at different expression levels: recombinogenic, mutagenic and clastogenic. These results indicate that the use of this extract carries a genetic risk and an analysis of the risk-benefit balance appears to be crucial (S´anchez-Lamar et al, 2008).…”

Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects

“…More recently, the genotoxicity of a hydroalcoholic pomegranate whole fruit extract was tested both in vitro and in vivo. The results indicated that to be toxic, doses greater than 70 mg/kg body weight were necessary (Sanchez-Lamar et al, 2008). The genotoxic effects reported by these researchers raised certain concerns over the safety of high intakes of PoMx in humans.…”

Antibacterial Activity of Punica granatum (Pomegranate) Fruit Peel Extract against Pathogenic and Drug Resistance Bacterial Strains

“…Punicalagins are the major ellagitannins in the whole fruit and can be hydrolyzed to ellagic acid and other smaller polyphenols in vivo (Jurenka, 2008;Lansky, 2007). Pomegranate has been used in traditional medicine for the treatment of dysentery, diarrhea, helminthiasis, and respiratory pathologies (Lansky 2005-Sánchez-Lamar, 2008. Currently there is considerable interest toward evaluating plant sources for alternative treatments against pathogenic bacteria which are now showing resistant to many drugs.…”