Assessment of the impact of genetically modified LibertyLink ® maize on reproductive function and progeny development of Wistar rats in three generations

Тышко, Н В; Zhminchenko, V. M.; Selyaskin, K.E.; Pashorina, V A; Utembaeva, N T; Tutelyan, V A

doi:10.1016/j.toxrep.2014.05.013

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…The study was conducted on pregnant and lactating Wistar rats at the clinic of laboratory animals of the Federal State Budgetary Institution “Institute of Nutrition” of the Russian Academy of Medical Sciences. During the preconception period and throughout the pregnancy and lactation, the females received the standard semi-synthetic diet according to [ 21 ]. The gestation period of the females was 20 days following conception; lactation period – on average 10–11 days after the birth of offspring.…”

Section: Methodsmentioning

confidence: 99%

Transfer of Silver Nanoparticles through the Placenta and Breast Milk during in vivo Experiments on Rats

et al. 2013

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Silver nanoparticles (NPs), widely used in the manufacture of various types of consumer products and for medical applications, belong to novel types of materials that pose potential risks to human health. The potential negative effects of the influence of these NPs on reproduction are insufficiently researched. A quantitative assessment of the transfer of metallic silver nanoparticles through the placenta and breast milk was carried out during an in vivo experiment. We used 34.9 ± 14.8 nm in size silver NPs that were stabilized by low-molecularweight polyvinylpyrrolidone and labeled with the 110mAg radioactive isotope using thermal neutron irradiation in a nuclear reactor. [110mAg]-labeled NPs preparations were administered intragastrically via a gavage needle to pregnant (20th day of gestation) or lactating (14–16th day of lactation) female rats at a dose of 1.69–2.21 mg/kg of body weight upon conversion into silver. The accumulation of NPs in rat fetuses and infant rats consuming their mother’s breast milk was evaluated using a low-background semiconductor gamma-ray spectrometer 24 and 48 hours following labeling, respectively. In all cases, we observed a penetration of the [110mAg]-labeled NPs through the placenta and ther entry into the mother’s milk in amounts exceeding by 100-1,000 times the sensitivity of the utilized analytical method. The average level of accumulation of NPs in fetuses was 0.085–0.147% of the administered dose, which was comparable to the accumulation of the label in the liver, blood, and muscle carcass of adult animals and exceeded the penetration of NPs across the hematoencephalic barrier into the brain of females by a factor of 10-100. In lactating females, the total accumulation of [110mAg]-labeled NPs into the milk exceeded 1.94 ± 0.29% of the administered dose over a 48 h period of lactation; not less than 25% of this amount was absorbed into the gastrointestinal tract of infant rats. Thus, this was the first time experimental evidence of the transfer of NPs from mother to offspring through the placenta and breast milk was obtained.

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Section: Methodsmentioning

confidence: 99%

Transfer of Silver Nanoparticles through the Placenta and Breast Milk during in vivo Experiments on Rats

et al. 2013

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“…GM rice, soybean, maize, and wheat, alone or in combination, have been fed to rats, broiler chickens, layer hens, dairy cows, monkeys, frogs, and pigs. Most of the studies conducted lasted for up to 90 days and recorded pathological, hematological, histopathological, serum chemistry, macroscopic, food intake, and reproduction-related characteristics (Tyshko et al 2014, Tyshko andSadykova, 2016). In all the studies, only minor or no adverse changes were recorded and the general conclusions were that GM food and feed have no hazardous effects compared with non-GM diets.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

Tsatsakis

Nawaz

Tutelyan

et al. 2017

Food and Chemical Toxicology

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Modern agriculture provides the potential for sustainable feeding of the world's increasing population. Up to the present moment, genetically modified (GM) products have enabled increased yields and reduced pesticide usage. Nevertheless, GM products are controversial amongst policy makers, scientists and the consumers, regarding their possible environmental, ecological, and health risks. Scientific-and-political debates can even influence legislation and prospective risk assessment procedure. Currently, the scientifically-assessed direct hazardous impacts of GM food and feed on fauna and flora are conflicting; indeed, a review of literature available data provides some evidence of GM environmental and health risks. Although the consequences of gene flow and risks to biodiversity are debatable. Risks to the environment and ecosystems can exist, such as the evolution of weed herbicide resistance during GM cultivation. A matter of high importance is to provide precise knowledge and adequate current information to regulatory agencies, governments, policy makers, researchers, and commercial GMO-releasing companies to enable them to thoroughly investigate the possible risks.

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“…ree studies reported sperm parameters over 90 days, while others indicated shorter periods [5][6][7]. One study was conducted on mice [8] and rats [5][6][7][9][10][11]. GM crops were rice in 4 studies [6][7][8][9] and maize [5] and potato [11] in the other studies.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Genetically Modified Food on Infertility Indices: A Systematic Review Study

Keshani

Sharifi

Heydari

et al. 2020

The Scientific World Journal

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Background and Objectives. With the increase in the growth of genetically modified (GM) crops, concerns as to the adverse effects of GM crops have risen in the community. The present systematic review seeks to assess the GM plants’ potential impacts on the sperm parameters, including sperm head, sperm motility, sperm abnormality, and fertility index. Materials and Methods. A structured literature search was independently performed by three authors on Scopus, Web of Science, PubMed, and Embase in January 2019. A total of 1467 publications were obtained by the search strategy after eliminating the duplicates. Moreover, the review only included articles written in English language. Other pertinent peer-reviewed publications were chosen (“snowballing”) from the reference lists in the selected publications. To assess the GM crop effects on infertility, experimental studies designed with the control group were selected. On the basis of abstract screening and full-text reviewing, 39 relevant publications were selected, seven of which were used in our review. To access the quality of articles, we used the Cochrane checklist. The collected articles were scored independently by three authors, and the publications with the eligibility criteria were included in our review. No article was excluded due to quality assessment. Results and Conclusion. Our findings indicated that GM products had no adverse effects on infertility indices such as the sperm head, sperm motility, sperm abnormality, and fertility indices. Long-term research still seems to be strongly necessary to ensure that the use of GM plants does not cause any harm to consumers, especially in infertility area.

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Assessment of the impact of genetically modified LibertyLink ® maize on reproductive function and progeny development of Wistar rats in three generations

Cited by 14 publications

References 32 publications

Transfer of Silver Nanoparticles through the Placenta and Breast Milk during in vivo Experiments on Rats

Transfer of Silver Nanoparticles through the Placenta and Breast Milk during in vivo Experiments on Rats

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

The Effect of Genetically Modified Food on Infertility Indices: A Systematic Review Study

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