Assessment of the Levels of Parathyroid Hormone, Oestrogen and Selected Bone Minerals in Menopausal Women

Abstract

Menopause is associated with various physiological and biochemical changes that have effects on bone minerals and their metabolism. There have been a lot of complaints about bone pains and bone related problems especially among middle aged women. Thus, the work was designed to assess and compare the levels of parathyroid hormone (PTH), oestrogen and selected bone minerals (calcium and phosphate) in preand post-menopausal women. A total of one hundred subjects were investigated. They comprised fifty premenopausal women within the ages of 20 years and 45 years and fifty post-menopausal women within the ages of 50 years and 65 years. The levels of parathyroid hormone, oestrogen, calcium and phosphate were measured in the subjects. Parathyroid hormone and oestrogen were analyzed using enzyme immunoassay technique while calcium and phosphate were analyzed using spectrophotometric method. The results showed that parathyroid hormone, calcium and phosphate were significantly increased (p<0.05) while there was decrease in oestrogen in post-menopausal women compared with premenopausal women. PTH and oestrogen correlated significantly at (p<0.01) in both pre-and post menopause. This study concluded that postmenopausal women have increased serum levels of parathyroid hormone, calcium and phosphate but decreased serum level of oestrogen. Significant positive correlation exists between PTH and oestrogen in both pre-and post menopause but no significant relationship between PTH and oestrogen with calcium and phosphate.

Bone degradation among elderly women in Douala, Cameroon: Biochemical markers, prevalence and associated factors

“…PTH levels were higher in women aged ≥ 75 years even though no statistically significant association between PTH and age was found in the study. This finding does not support those of previous studies that reported increasing PTH levels with age [16,17]. Indeed, Oluboyo and colleagues found significantly increased levels of PTH along with calcium and phosphorus among Nigerian postmenopausal women [17].…”

“…This finding does not support those of previous studies that reported increasing PTH levels with age [16,17]. Indeed, Oluboyo and colleagues found significantly increased levels of PTH along with calcium and phosphorus among Nigerian postmenopausal women [17].…”

Respuesta reproductiva de ovejas nulíparas expuestas a carneros tratados con selenio más vitamina E

“…E. Los resultados son contrarios a los encontrados en otros estudios que muestran que la aplicación de Se y Vit. E estimulan un mayor libido y mayor desempeño reproductivo en el macho (Ali et al 2009, Oluboyo et al 2012, Gamal et al 2013. Una probable causa, que pudo afectar el desempeño reproductivo de los carneros pudo deberse al intervalo de tratamiento y dosis utilizadas en nuestro tratamiento.…”

A comprehensive review of the bioactive components of sesame seeds and their impact on bone health issues in postmenopausal women

“…28 Subsequently, calcium is liberated from the bone when the parathyroid hormone levels are high, resulting in higher calcium blood levels. 29,30 Fig. 1 illustrates how menopause leads to bone issues.…”