Assessment of the Mechanistic Role of Cinnarizine in Modulating Experimentally-Induced Bronchial Asthma in Rats

Abdel-Fattah, Maha M.; Messiha, Basim Anwar Shehata; Salama, Abeer

doi:10.1159/000438705

Cited by 14 publications

(5 citation statements)

References 52 publications

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“…The salicylic acid derivative 5-aminosalicylic acid reduces leukocyte count, the expression of Th2 cytokines, and oxidative stress markers in the BALF from asthmatic mice [401]. Sitagliptin and Cinnarizine also reduce proinflammatory cytokine release and inflammatory infiltration, while restoring GSH and SOD, thus, playing a role attenuating airway inflammation and remodeling through antioxidative stress [402,403]. However, some of the above approaches have failed due to unanticipated side effects.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Checa

Aran

2020

IJMS

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As aerobic organisms, we are continuously and throughout our lifetime subjected to an oxidizing atmosphere and, most often, to environmental threats. The lung is the internal organ most highly exposed to this milieu. Therefore, it has evolved to confront both oxidative stress induced by reactive oxygen species (ROS) and a variety of pollutants, pathogens, and allergens that promote inflammation and can harm the airways to different degrees. Indeed, an excess of ROS, generated intrinsically or from external sources, can imprint direct damage to key structural cell components (nucleic acids, sugars, lipids, and proteins) and indirectly perturb ROS-mediated signaling in lung epithelia, impairing its homeostasis. These early events complemented with efficient recognition of pathogen- or damage-associated recognition patterns by the airway resident cells alert the immune system, which mounts an inflammatory response to remove the hazards, including collateral dead cells and cellular debris, in an attempt to return to homeostatic conditions. Thus, any major or chronic dysregulation of the redox balance, the air–liquid interface, or defects in epithelial proteins impairing mucociliary clearance or other defense systems may lead to airway damage. Here, we review our understanding of the key role of oxidative stress and inflammation in respiratory pathology, and extensively report current and future trends in antioxidant and anti-inflammatory treatments focusing on the following major acute and chronic lung diseases: acute lung injury/respiratory distress syndrome, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and cystic fibrosis.

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Section: Preclinical Studiesmentioning

confidence: 99%

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Checa

Aran

2020

IJMS

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“…The present study explained the administration of cinnarizine causes significant reduction in the expression of immunohistochemistry for colonic cytokines (interleukin-4 and tumor necrosis factor-α) in experimentally induced colitis in rats. Previous study showed that Cinnarizine has anti-inflammatory through itʼs suppressant effect on pro inflammatory cytokines TNF-α, IL-1, and IL-6 release in experimentally-induced bronchial asthma in rats (35).…”

Section: Discussionmentioning

confidence: 95%

“…The study has also shown that administration of cinnarizine significantly reduce the expression of immunohistochemistry for markers of oxidative stress (myeloperoxidase and malondialdehyde) in colonic mucosa of experimentally induced colitis in rats. Studies have suggested that cinnarizine reduces the immune response through inhibition of endothelial oxidative stress and nuclear factor (NF-κB) action (the transcription factor through signaling pathways of phospholipase C and the phosphatidylinositol) (35).…”

Section: Discussionmentioning

confidence: 99%

Comparative treatment of induced ulcerative colitis in male rat model by using cinnarizine and sulfasalazine

Atarbashe¹,

Abu-Raghif²

2020

IJVS

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Ulcerative colitis is a chronic and intermittent illness. The current treatment failed to cure the disease which requires to investigate other drug with minimal side effects. The goal of the research is to assess the histological outcome, antioxidant and anti-inflammatory effects of cinnarizine in comparison with that of sulfasalazine (salazosulfapyridine) in experimentally induced colitis in rats. Acetic acid 4% (vol/vol) was used rectally to induce experimental colitis in rats. After induction, rats were administered either sulfasalazine 100mg/kg or cinnarizine 20 mg/kg as a therapeutic dose in rats orally for one week. The duration of treatment was depended on previous studies. There were estimation of histopathological and clinical parameters also the expression of cytokines (tumor necrosis factor alpha (TNF-α) and interleukin-4 (IL-4)), oxidative stress markers (malondialdehyde (MDA) and myeloperoxidase (MPO)), and adhesion molecules (intercellular adhesion molecule-1 (ICAM-1) and endothelial (E)-Selectin) in the colonic tissue. Results showed that both cinnarizine and sulfasalazine significantly reduced the clinical and histological injury in colon that induced by acetic acid. In addition to the down regulation of the increased colonic cytokines, MDA, MPO parameters and adhesive molecules. These results concluded that cinnarizine had an effective therapeutic role which is comparable with sulfasalazine on the experimental colitis through anti-inflammatory and antioxidant actions with down regulation the colonic adhesion molecule.

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“… 2016 ), bronchial asthma (Abdel-Fattah et al. 2015a , 2015b ), ulcerative colitis (Ewees et al. 2016 ) and neurodegeneration (Ali et al.…”

Section: Discussionmentioning

confidence: 99%

Quillaja saponaria bark saponin protects Wistar rats against ferrous sulphate-induced oxidative and inflammatory liver damage

Abdel-Reheim

Messiha

Abo-Saif

2017

Pharmaceutical Biology

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Context: Saponins from different sources are historically reported in Chinese medicine to possess many beneficial effects. However, insufficient experimental data are available regarding the hepatoprotective potential of Quillaja bark saponin.Objective: The protective effect of Quillaja saponaria Molina (Quillajaceae) bark triterpenoid saponin against iron-induced hepatotoxicity is compared to the standard N-acetylcysteine in adult male Wistar rats.Materials and methods: Animals were divided into (six) groups, namely a normal control, an N-acetylcysteine control (300 mg/kg/day, p.o., 10 days), a saponin control (100 mg/kg/day, p.o., for 10 days), a hepatotoxicity control (two doses of ferrous sulphate, 30 mg/kg/day each, i.p., on 9th and 10th day), an N-acetylcysteine plus ferrous sulphate (standard treatment) and a saponin plus ferrous sulphate (test treatment) group. Hepatocyte integrity loss markers (serum ALT, AST, ALP, GGT and LDH), oxidative stress markers (hepatic MDA, GSH and NOx), dyslipidaemic markers (serum TC and TG) and hepatocyte functioning markers (serum bilirubin and albumin) were assessed.Results:Quillaja bark saponin decreased iron-induced elevation of ALT (reaching 57% of hepatotoxicity control), AST (66%), ALP (76%), GGT (60%), LDH (54%), MDA (65%), NOx (77%), TC (70%), TG (54%), and total (54%), direct (54%) and indirect (54%) bilirubin, coupled with increased GSH (219%) and albumin (159%) levels. Histopathological study strongly supported biochemical estimations, while immunohistochemical study showed marked effect on eNOS and iNOS expression.Conclusions:Quillaja bark saponin has a good hepatoprotective effect. Amelioration of oxidative stress and suppression of NOS expression, with resultant maintenance of hepatocyte integrity and functioning, may explain this beneficial effect.

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Assessment of the Mechanistic Role of Cinnarizine in Modulating Experimentally-Induced Bronchial Asthma in Rats

Cited by 14 publications

References 52 publications

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology

Comparative treatment of induced ulcerative colitis in male rat model by using cinnarizine and sulfasalazine

Quillaja saponaria bark saponin protects Wistar rats against ferrous sulphate-induced oxidative and inflammatory liver damage

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