Assessment of the phototoxic potential of cosmetic products

Hans, R.K.; Agrawal, N K; Verma, K.; Misra, R.B.; Ray, Ratan Singh; Farooq, Muhammad Asim

doi:10.1016/j.fct.2008.01.005

Cited by 29 publications

(14 citation statements)

References 22 publications

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“…Few studies concerning the effects of consumer products on human health have been reported. Hans et al (2008) investigated the phototoxic potential of cosmetic products in India. The study revealed that six lipsticks and five facial creams generated reactive oxygen species produced haemolysis and caused lipid peroxidation in human erythrocytes (in vitro) under sunlight exposure.…”

Section: Introductionmentioning

confidence: 99%

Safety evaluation of heavy metals exposure from consumer products

Odukudu

Ayenimo

Adekunle

et al. 2013

Int J Consumer Studies

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The determination of heavy metals in consumer products is crucial for the safety appraisal and sources classification of human and environmental exposures. These products contain various undisclosed chemical constituents with no or little known health safety information. The public is generally unaware of these types of everyday exposure from chemical constituents of consumer products and their health consequences. In this study, we recorded a body of proof demonstrating potential harm of consumer goods, by determining concentrations of total cadmium (Cd), chromium (Cr), copper (Cu), zinc (Zn), iron (Fe), lead (Pb) and nikel (Ni contents in a variety of personal care products (n = 82) commonly used in Nigeria, using flame atomic absorption spectrometer after dry and wet digestion methods. The results of the analysis indicated that the range of Cd was 0.035 ± 0.023–0.467 ± 0.167 ppm, Cr 0.015 ± 0.009–0.435 ± 0.232 ppm, Cu 0.230 ± 0.08–0.603 ± 0.025 ppm, Zn 0.003 ± 0.005–0.743 ± 0.066 ppm, Fe 0.233 ± 0.219–1.401 ± 1.878 ppm, Pb 0.02 ± 0.007–0.2050.129 ppm and Ni 0.035 ± 0.015–0.093 ± 0.06 ppm. The values of Cd and Cr are a cause for alarm because the elements are not allowed in any amount in cosmetics. Despite the fact that zinc is essential in the body, the values obtained in this study deserves safety concerns due to cumulative effect, arising from incessant exposure.

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Section: Introductionmentioning

confidence: 99%

Safety evaluation of heavy metals exposure from consumer products

Odukudu

Ayenimo

Adekunle

et al. 2013

Int J Consumer Studies

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“…Interestingly, some components of cosmetic products, such as lipsticks and facial creams, have been shown to produce ROS themselves and cause hemolysis and lipid peroxidation in human erythrocytes under sunlight exposure (Hans et al, 2008). SOD can indeed by very useful in averting such effects.…”

Section: Critical Reviews In Biotechnologymentioning

confidence: 99%

Superoxide dismutase: an industrial perspective

Bafana

Dutt

Kumar

et al. 2010

Critical Reviews in Biotechnology

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The application of enzyme technologies to industrial research, development, and manufacturing has become a very important field. Since the production of crude rennet in 1874, several enzymes have been commercialized, and used for therapeutic, supplementary, and other applications. Recent advancements in biotechnology now allow companies to produce safer and less expensive enzymes with enhanced potency and specificity. Antioxidant enzymes are emerging as a new addition to the pool of industrial enzymes and are surpassing all other enzymes in terms of the volume of research and production. In the 1990s, an antioxidant enzyme--superoxide dismutase (SOD)--was introduced into the market. Although the enzyme initially showed great promise in therapeutic applications, it did not perform up to expectations. Consequently, its use was limited to non-drug applications in humans and drug applications in animals. This review summarizes the rise and fall of SOD at the industrial level, the reasons for this, and potential future thrust areas that need to be addressed. The review also focuses on other industrially relevant aspects of SOD such as industrial importance, enzyme engineering, production processes, and process optimization and scale-up.

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“…Results are evaluated by comparing the concentration of the test chemical and inhibition in uptake of 50% of cellular NRU. This test demonstrated predictive value of 95-100%, hence, is considered a reliable source for the prediction of phototoxicity of an ingredient or a formulation [28][29].…”

Section: In Vitro 3t3 Neutral Red Uptake Phototoxicity Test (3t3 Nru Pt)mentioning

confidence: 99%

Review on Safety Assessment of a Cosmetic Product

Bhuvaneswari

Chandan

2018

Int J Curr Pharm Sci

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Cosmetics can be defined as, “substances which are intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body’s structure or functions” according to USFDA. This review encompasses a brief description of the process of safety assessment of a cosmetic product. There is no significant systemic absorption of cosmetics by penetration through skin, but some products are intended to apply on the mucous membranes or skin surrounding the mucous membranes which may result in significant systemic absorption on continuous use. Serious health hazards have not been observed mostly, but in some cases, lead to severe reactions like, allergy, irritation, comedogenicity, genotoxicity, photosensitivity etc. At the same time, long terms effects of usage of cosmetics are still unknown as the products are used repeatedly over a long period of time. Hence, safety evaluation of a cosmetic product is the most prominent step before release of the product into the market. There are no specific safety regulations for cosmetics, but the safety of the product is the responsibility of the manufacturer. The article explains about different organizations that are responsible for the safety of the cosmetic products before they are released into the market in different countries and also about the Product Information File (PIF). The safety of a cosmetic product both at industrial level and finished product level are explained. The different tests deployed for the safety assessment of a cosmetic product are also explained.

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Assessment of the phototoxic potential of cosmetic products

Cited by 29 publications

References 22 publications

Safety evaluation of heavy metals exposure from consumer products

Safety evaluation of heavy metals exposure from consumer products

Superoxide dismutase: an industrial perspective

Review on Safety Assessment of a Cosmetic Product

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