Assessment of the psychometric properties of the 17- and 6-item Hamilton Depression Rating Scales in major depressive disorder, bipolar depression and bipolar depression with mixed features

Silva, Alexandre Kieslich da; Reche, M; Lima, Ana Flavia Da Silva; Fleck, Marcelo Pio de Almeida; Capp, Edison; Shansis, Flávio

doi:10.1016/j.jpsychires.2018.07.009

Cited by 16 publications

(8 citation statements)

References 41 publications

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“…Importantly, the HAMD-6 is an effective tool in heterogeneous depression samples. 14 To our knowledge, this is the first study to use the HAMD-6 in a consideration of the response of symptoms of MDE to an adequate course of TMS. Among those who achieved remission, treatment produced significant reduction in all six items.…”

Section: Discussionmentioning

confidence: 91%

Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode

May

Pridmore

2019

Australas Psychiatry

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Objectives: This study aimed to explore the effects of a four-week course of transcranial magnetic stimulation (TMS) on the following symptoms of major depressive episode (MDE): mood, work activities, health concerns, guilt, anxiety and retardation. Method: Patients underwent 20 daily sessions of 10 Hz TMS (two sets of 10 daily treatments separated by two days of rest). The six-item Hamilton Depression Rating Scale (HAMD-6) was administered before and after treatment. Remission was operationalised as a HAMD-6 score of <4. Descriptive statistics and t-tests were used to compare pre/post scores on HAMD-6 subscales, and logistic regression was used to understand symptoms that predicted remission/non-remission. Results: There were 104 participants (79 female; 76%), with a mean age of 44.6 years ( SD=15.7 years). There was a significant improvement in the whole sample and in remitters ( n=70) on all subscales. However, those who failed to remit did not achieve significant reductions in ‘health concerns’ and ‘retardation’. There were no difference in age and sex between remitters and non-remitters. Also, there were no significant differences between the remitters and non-remitters on the pretreatment depression symptom profiles. No predictors of response were identified, as expected. Conclusions: TMS has the ability to reduce all listed MDE symptoms. No pretreatment MDE symptom profile was identified which might carry prognostic value.

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Section: Discussionmentioning

confidence: 91%

Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode

May

Pridmore

2019

Australas Psychiatry

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“…Bech and his research group conducted a number of studies in which they analyzed the scalability of the various versions of the HAM-D [14,20,96,98,100,[165][166][167][168][169][170][171][172]. In these studies, including a recent paper by da Silva et al [173], the HAM-D 6 was found to have an excellent level of scalability with Mokken coefficients ranging from 0.42 [172] to 0.65 [169]. Studies using the Rasch analysis further confirmed the scalability of the unstructured version of the HAM-D 6 [96,165,170].…”

Section: Scalability Of the Different Versions Of The Ham-dmentioning

confidence: 99%

The Hamilton Rating Scales for Depression: A Critical Review of Clinimetric Properties of Different Versions

Carrozzino

Patierno

Fava

et al. 2020

Psychother Psychosom

180

110

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The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured: only general instructions were provided for rating individual items. Over the years, a number of modified versions of the HAM-D have been proposed. They differ not only in the number of items, but also in modalities of administration. Structured versions, including item definitions, anchor points and semi-structured or structured interview questions, were developed. This comprehensive review was conducted to examine the clinimetric properties of the different versions of the HAM-D. The aim was to identify the HAM-D versions that best display the clinimetric properties of reliability, validity, and sensitivity to change. The search was conducted on MEDLINE, Scopus, Web of Science, and PubMed, and yielded a total of 35,473 citations, but only the most representative studies were in-cluded. The structured versions of the HAM-D were found to display the highest inter-rater and test-retest reliability. The Clinical Interview for Depression and the 6-item HAM-D showed the highest sensitivity in differentiating active treatment from placebo. The findings indicate that the HAM-D is a valid and sensitive clinimetric index, which should not be discarded in view of obsolete and not clinically relevant psychometric criteria. The HAM-D, however, requires an informed use: unstructured forms should be avoided and the type of HAM-D version that is selected should be specified in the registration of the study protocol and in the methods of the trial. scale exceeds 21,000 on Scopus. Hamilton himself recommended, however, to use only the first 17 items of the HAM-D 21 since the last 4 symptoms (i.e., diurnal variation, depersonalization/derealization, paranoid and obsessional/compulsive symptoms) were either not considered part of the disease, or they were relatively uncommon, or they were not considered features related to depression severity [2,3]. Over the years, a number of modifications of the scale have been proposed and several versions of the HAM-D have been developed and come into use [4,5].

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“…Hamilton [ 19 ] provides detailed information on the HAM-D 17 scale. Overall acceptable psychometric properties have been reported for the HAM-D, including internal consistency [ 21 ]. In our study, the Cronbach alphas for the HAM-D 17 was 0.86 at before treatment and 0.84 at the end of CRT.…”

Section: Methodsmentioning

confidence: 99%

Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study

González-Mercado

Lim

Saligan

et al. 2021

Depression Research and Treatment

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Background. The role of alterations in gut microbiota composition (termed dysbiosis) has been implicated in the pathobiology of depressive symptoms; however, evidence remains limited. This cross-sectional pilot study is aimed at exploring whether depressive symptom scores changed during neoadjuvant chemotherapy and radiation therapy to treat rectal cancer, and if gut microbial taxa abundances and predicted functional pathways correlate with depressive symptoms at the end of chemotherapy and radiation therapy. Methods. 40 newly diagnosed rectal cancer patients (ages 28-81; 23 males) were assessed for depressive symptoms using the Hamilton Rating Scale for Depression (HAM-D) and provided stool samples for 16S rRNA sequencing. Gut microbiome data were analyzed using QIIME2, and correlations and regression analyses were performed in R. Results. Participants had significantly higher depressive symptoms at the end as compared to before CRT. The relative abundances of Gemella, Bacillales Family XI, Actinomyces, Streptococcus, Lactococcus, Weissella, and Leuconostocaceae were positively correlated (Spearman’s rho = 0.42 to 0.32), while Coprobacter, Intestinibacter, Intestimonas, Lachnospiraceae, Phascolarctobacterium, Ruminiclostridium, Ruminococcaceae (UCG-005 and uncultured), Tyzzerella, and Parasutterella (Spearman’s rho = − 0.43 to − 0.31 ) were negatively correlated with HAM-D scores. Of the 14 predicted MetaCyc pathways that correlated with depressive symptom scores at the end of CRT, 11 (79%) were associated with biosynthetic pathways. Conclusions. Significant bacterial taxa and predicted functional pathways correlated with depressive symptoms at the end of chemotherapy and radiation therapy for rectal cancer which warrants further examination and replication of our findings.

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Assessment of the psychometric properties of the 17- and 6-item Hamilton Depression Rating Scales in major depressive disorder, bipolar depression and bipolar depression with mixed features

Cited by 16 publications

References 41 publications

Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode

Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode

The Hamilton Rating Scales for Depression: A Critical Review of Clinimetric Properties of Different Versions

Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study

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