2014
DOI: 10.1185/03007995.2014.957824
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Assessment of the safety and efficacy of extended-release oxycodone/acetaminophen, for 14 days postsurgery

Abstract: These results show that ER OC/APAP demonstrated an expected safety and tolerability profile and good patient satisfaction in a postsurgical model of acute pain.

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Cited by 9 publications
(5 citation statements)
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“…In an open-label extension study of the above trial lasting at least 14 days, tolerability of XARTEMIS™ XR was consistent with that of an opioid product and AEs occurred in 43.8% of patients [ 42 ]. The most common AEs reported in this extension study were nausea (17.8%), vomiting (7.5%), and constipation (6.2%).…”
Section: Efficacy and Safety Of The Oxycodone/acetaminophen Fixed-dosmentioning
confidence: 85%
“…In an open-label extension study of the above trial lasting at least 14 days, tolerability of XARTEMIS™ XR was consistent with that of an opioid product and AEs occurred in 43.8% of patients [ 42 ]. The most common AEs reported in this extension study were nausea (17.8%), vomiting (7.5%), and constipation (6.2%).…”
Section: Efficacy and Safety Of The Oxycodone/acetaminophen Fixed-dosmentioning
confidence: 85%
“…Patients were administered these drugs every 12 hours over 14 days. Both products demonstrated good pain control with side effects consistent with opioid products, which occurred in 43.8% of patients [30].…”
Section: Oxycodone and Acetaminophenmentioning
confidence: 86%
“…The use of a combination of analgesics (NSAIDs, glucocorticoids, and opioids) could have many advantages, such as the induction of analgesia by different mechanisms of action, improved rapid recovery after surgery, less general toxicity, and adverse effects because the combination of drugs allows reducing the doses, particularly how much synergistic analgesic effects can be obtained using a combination of two or more drugs [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. It is important to mention that evidence can also be found in clinical trials on the use of other opioid analgesics alone, or in combination with other types of drugs, to treat postoperative pain after a bunionectomy, such as tramadol [ 31 , 32 ], oxycodone [ 7 , 33 , 34 , 35 ], and morphine [ 33 , 36 , 37 ].…”
Section: Discussionmentioning
confidence: 99%