Assessment of the Separation of X- and Y-Chromosome Bearing Sperms of Fertile Men by Albumin Gradients Using Real Time PCR

Baheri, Sahar; Saki, Ghasem; Asl, Javad Mohammadi; Khodadadi, Ali

doi:10.17795/jjhr-31079

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…On the other hand, many researchers including (17,21,22) confirmed the effectiveness of this method, especially in determining the male gender. Meanwhile, other researchers believed that this method was ineffective (17,23). However, Fugger's study suggests that the health of the baby after delivery has been confirmed by this method (24).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Success Rate of Sex Selection in Cycles of Intrauterine Insemination of Sperm Using an Albumin Gradient Method in Infertile Couples Referring to the Omid Persian Gulf Infertility Center of Bushehr, Iran

Ahmadi¹,

Rahmani²,

Motamed³

et al. 2016

International Journal of Women’s Health and Reproduction Scienc

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Section: Discussionmentioning

confidence: 99%

Investigating the Success Rate of Sex Selection in Cycles of Intrauterine Insemination of Sperm Using an Albumin Gradient Method in Infertile Couples Referring to the Omid Persian Gulf Infertility Center of Bushehr, Iran

Ahmadi¹,

Rahmani²,

Motamed³

et al. 2016

International Journal of Women’s Health and Reproduction Scienc

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“…1 The reasons include; cultural, social and economic preferences, gene linked diseases and family balancing. 2 Even the infertile patients have significant demand for preimplantation sex selection, with a significant portion of this demand coming from patients who do not have any child or have all children of same sex. 3 The publication of article on separation of X-and Y-bearing spermatozoa using albumin gradients 4 gained high popularity.…”

Section: Introductionmentioning

confidence: 99%

Does gradients or swim up procedure produce baby of desired gender?

Javed¹,

Laqwer²,

Mahouk³

et al. 2019

OGIJ

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Background: Pre selection of baby gender is still desire of many parents. A number of procedures have been used including X and Y sperm separation by various semen processing procedures for intrauterine insemination (IUI), sperm sorting by flowcytometry, fluorescent in situ hybridization and preimplantation genetic testing (PGT). Due to low cost, simplicity and easy availability, various X-and Y-bearing sperm separation procedures followed by IUI have been commonly used but with conflicting accuracy. The most common sperm separation procedures include; gradients filtration, swim up, swim down and albumin gradients filtration. The objective of this study was to investigate whether swim-up or density gradient semen processing followed by IUI results in significant deviation in the ratio of male and female babies. Methods: The study was carried out retrospectively at Thuriah Medical Center. The data of 990 IUI cycles from Jan 2016 to Dec 2017 were analyzed. The semen samples were processed by gradient filtration, swim up or simple wash depending on quality of the sample and desire of patient. Data on female and male age, total progressively motile sperm inseminated, pregnancy rate and delivery of male or female baby were recorded and analyzed. Results: Gradient filtration, swim up and simple wash were used in 69, 26 and 5 % samples, respectively. Male or female ages in different groups were not significantly different (P<0.05). Biochemical pregnancy rates were highest in the swim up group and lowest in the simple wash group. Conclusion: Based on the results of this study, the gender ratio did not change significantly from the natural ratio of about 50/50; therefore, sperm separation by these procedures for gender selection is not accurate.

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Assessment of the Separation of X- and Y-Chromosome Bearing Sperms of Fertile Men by Albumin Gradients Using Real Time PCR

Cited by 2 publications

References 20 publications

Investigating the Success Rate of Sex Selection in Cycles of Intrauterine Insemination of Sperm Using an Albumin Gradient Method in Infertile Couples Referring to the Omid Persian Gulf Infertility Center of Bushehr, Iran

Investigating the Success Rate of Sex Selection in Cycles of Intrauterine Insemination of Sperm Using an Albumin Gradient Method in Infertile Couples Referring to the Omid Persian Gulf Infertility Center of Bushehr, Iran

Does gradients or swim up procedure produce baby of desired gender?

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