Trough girders are widely accepted in engineering on account of lowing construction depth and protection against traffic noise pollution, but most of them are used for simple‐supported girder bridges with a span of generally less than 30 m. On the railway line of Nanjing–Qidong in China a new railway bridge will be built which has a span of over 64 m but a construction depth of less than 2.4 m on which Shanghai–Nantong railway line is also passed, so the type of concrete‐filled steel tube tied‐arch bridge with trough girder was chosen. For such a new structure hardly used in engineering, there are no research results yet available about mechanical properties of the structure. This paper therefore makes for the bridge an experimental model of 1:4 geometric scale in order to test mechanical properties under operation load, cracking load, and ultimate load such as cracking diagram, load‐carrying capacity, stress distribution, and failure mechanism. According to the experimental results, when the model is subjected to longitudinal bending moment, the failure mode is similar to that of pure bending of a girder, and when the model is subjected to transverse bending moment failure mode behaves like the flexural failure mode of the traditional reinforced concrete structure. A non‐linear element analysis is also made on the model with the results in good agreement with that of the experiment. The same modeling method is applied to the finite element analysis of the real bridge, considering various load in design. In the analysis, it is finally verified that this new type of bridge meets specification requirements in strength, rigidity, and resistance to cracking.