Assessment of the structures contribution (crystalline and mesophases) and mechanical properties of polycaprolactone/pluronic blends

Tenorio‐Alfonso, Adrián; Ramos, E Vázquez; Martínez, Inmaculada José Martínez; Ambrosi, Moira; Raudino, Martina

doi:10.1016/j.jmbbm.2023.105668

Cited by 10 publications

(8 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three distinct diffraction peaks characteristic of the PLA crystalline α phase were visible in the XRD pattern of the pure PLA film at 2θ angles of 16.8°, 19.2° and 22.6° [ 45 , 46 ]. The XRD pattern for the PCL film showed strong diffraction peaks at 21.4° and 23.7° 2θ, which is consistent with the literature [ 47 , 48 , 49 ]. The PLA/PCL film showed main diffraction peaks corresponding to the PLA crystalline α phase at 16.8° and 19.2° 2θ and no visible diffraction peaks related to crystalline PCL ( Figure 7 a).…”

Section: Resultssupporting

confidence: 91%

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Alexeeva,

Olkhov,

Konstantinova

et al. 2023

Polymers

View full text Add to dashboard Cite

The product of ozonolysis, glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, [OTOA]), was incorporated into polylactic acid/polycaprolactone (PLA/PCL) blend films in the amount of 1, 5, 10, 20, 30 and 40% w/w. The morphological, mechanical, thermal and antibacterial properties of the biodegradable PLA/PCL films after the OTOA addition were studied. According to DSC and XRD data, the degree of crystallinity of the PLA/PCL + OTOA films showed a general decreasing trend with an increase in OTOA content. Thus, a significant decrease from 34.0% for the reference PLA/PCL film to 15.7% for the PLA/PCL + 40% OTOA film was established using DSC. Observed results could be explained by the plasticizing effect of OTOA. On the other hand, the PLA/PCL film with 20% OTOA does not follow this trend, showing an increase in crystallinity both via DSC (20.3%) and XRD (34.6%). OTOA molecules, acting as a plasticizer, reduce the entropic barrier for nuclei formation, leading to large number of PLA spherulites in the plasticized PLA/PCL matrix. In addition, OTOA molecules could decrease the local melt viscosity at the vicinity of the growing lamellae, leading to faster crystal growth. Morphological analysis showed that the structure of the films with an OTOA concentration above 20% drastically changed. Specifically, an interface between the PLA/PCL matrix and OTOA was formed, thereby forming a capsule with the embedded antibacterial agent. The moisture permeability of the resulting PLA/PCL + OTOA films decreased due to the formation of uniformly distributed hydrophobic amorphous zones that prevented water penetration. This architecture affects the tensile characteristics of the films: strength decreases to 5.6 MPa, elastic modulus E by 40%. The behavior of film elasticity is associated with the redistribution of amorphous regions in the matrix. Additionally, PLA/PCL + OTOA films with 20, 30 and 40% of OTOA showed good antibacterial properties on Pseudomonas aeruginosa, Raoultella terrigena (Klebsiella terrigena) and Agrobacterium tumefaciens, making the developed films potentially promising materials for wound-dressing applications.

show abstract

Section: Resultssupporting

confidence: 91%

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Alexeeva,

Olkhov,

Konstantinova

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

“…To provide a prolonged protection and the controlled release of the inhibitor when the protective layer is damaged in a corrosive environment, the microcontainers within the PEO coating were sealed by a biodegradable polymer, polycaprolactone (PCL) [ 31 , 32 ]. Polycaprolactone is an FDA-approved [ 33 , 34 ] biopolymer material, commonly used in surgery and tissue engineering, as well as for the design of drug-delivery systems [ 35 , 36 , 37 , 38 ]. Considering the use of the material in medical practice, it can be concluded that PCL provides biocompatibility, an appropriate rate of biodegradation with non-toxic degradation products, processability, and accessibility [ 31 , 33 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Coatings for Active Protection against Corrosion of Mg and Its Alloys

et al. 2023

View full text Add to dashboard Cite

A novel approach to surface modification was developed to improve the corrosion performance of biodegradable magnesium alloys. Additively manufactured magnesium samples and Mg-Mn-based magnesium alloys were used in this study. This method involves the combination of plasma electrolytic oxidation to create a porous ceramic-like matrix, followed by treatment with protective biocompatible agents. The most efficient method for the PEO-layer impregnation using sodium oleate and polycaprolactone was selected and optimized. The correlation between the structure, composition, and protective properties of the hybrid coatings was established. The composition of the formed polymer-containing layers was established using XPS and Raman microspectroscopy. The presence of sodium oleate and its distribution across the coating surface was confirmed at the microscale. The corrosion-protection level of the hybrid layers was assessed using potentiodynamic polarization measurements, electrochemical impedance spectroscopy, hydrogen evolution testing, and gravimetry (mass-loss tests) in vitro. The oleate-containing polycaprolactone layers (HC-SO 0.1–2) demonstrated stable corrosion behavior even after 7 days of immersion in Hank’s balanced salt solution. The corrosion-current density and impedance modulus measured at a frequency of 0.1 Hz for the samples with hybrid coating after 7 days of exposure were equal to 5.68 × 10−8 A∙cm−2 and 2.03 × 106 Ω∙cm2, respectively. The developed method of surface modification demonstrates the coating’s self-healing properties. The effectiveness of employing hybrid anticorrosive bioactive PEO coatings for biomedical products made from magnesium and its alloys was demonstrated.

show abstract

“…Such splitting was also reported in the literature on PCL/Pluoronics blends that are immersed in water inside hermetic containers for a duration of 1 year. [ 61 ] In the case of lysozyme‐derivatized PCL films, the derivatization process was found to result in an increase in the intensity of the (200) plane, almost equal to that of (110). This could be correlated to the highest percentage of crystallinity through DTA measurements observed for this sample among all the controls.…”

Section: Resultsmentioning

confidence: 99%

Probing the Effects of Antimicrobial‐Lysozyme Derivatization on Enzymatic Degradation of Poly(ε‐caprolactone) Film and Fiber

Maroju

Ganesan

Dutta

2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Surface derivatization is essential for incorporating unique functionalities into biodegradable polymers. Nonetheless, its precise effects on enzymatic biodegradation still lack comprehensive understanding. In this study, a facile solution‐based method is employed to surface derivatize poly(ε‐caprolactone) (PCL) films and electrospun fibers with lysozyme, aiming to impart antimicrobial properties and examine the impact on enzymatic degradation. The derivatized films and fibers have shown high antibacterial efficacy against E. coli and S. aureus. Through gravimetric analysis, it has been observed that the degradation rate experiences a slight decrease upon lysozyme derivatization. However, this reduction is effectively countered by the inclusion of Tween‐20, as affirmed by isothermal titration calorimetry. Comparing films and fibers, the latter undergoes degradation at a more accelerated pace, coupled with a rapid decline in molecular weight. This study provides valuable insights into the factors influencing the degradation of surface‐derivatized biopolymers through electrospinning, offering a simple strategy to mitigate biomaterial‐associated infections.This article is protected by copyright. All rights reserved

show abstract

Assessment of the structures contribution (crystalline and mesophases) and mechanical properties of polycaprolactone/pluronic blends

Cited by 10 publications

References 49 publications

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

A Novel Approach for Glycero-(9,10-trioxolane)-Trialeate Incorporation into Poly(lactic acid)/Poly(ɛ-caprolactone) Blends for Biomedicine and Packaging

Hybrid Coatings for Active Protection against Corrosion of Mg and Its Alloys

Probing the Effects of Antimicrobial‐Lysozyme Derivatization on Enzymatic Degradation of Poly(ε‐caprolactone) Film and Fiber

Contact Info

Product

Resources

About