Assessment of the toxicity of organochlorine pesticide endosulfan in clams Ruditapes philippinarum

Tao, Yadong; Pan, Luqing; Zhang, Hui; Tian, Shuangmei

doi:10.1016/j.ecoenv.2013.03.036

Cited by 55 publications

(14 citation statements)

References 54 publications

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“…DNA in bivalves has been approved as an effective biomarker to assess the genotoxicity of pollutants (Ching et al, 2001). The decrease on DNA damage observed in the present study were similar to those observed in crabs hepatopancreas tissues after exposure to carbamazepine and novobiocin (0.1-10 μg L À 1 ) (Aguirre-Martínez et al, 2013d) and are in line with results reported in digestive glands tissues of R. philippinarum exposed to endosulfan (Tao et al, 2013). Significant decrease of DNA strand breaks have been recorded in H. diversicolor after exposure to environmental concentration of fluoxetine, 17α-ethynylestradiol and propanolol (Maranho et al, 2014).…”

Section: Discussionsupporting

confidence: 95%

“…Moreover, this response has been recorded in R. philippinarum exposed to different organic compounds, for example, an increase of GST activity was observed in digestive gland tissues of these species when exposed to port sediments (Martín-Díaz et al, 2007), and also to sediment affected by oil spills (Morales-Caselles et al, 2008a. Additionally, an increase has been shown in digestive gland tissues of these species after exposure to organochlorine pesticide endosulfan (Tao et al, 2013). There is evidence on increment of GST activity in several aquatic invertebrates as a consequence of organic contamination, such as those reported for hepatopancreas tissues of C. maenas when exposed to port sediments (Martín-Díaz et al, 2007), and to sediment affected by oil spills (MoralesCaselles et al, 2008a(MoralesCaselles et al, , 2008b; in digestive gland tissues of M. galloprovincialis exposed to sites contaminated with organic compounds (Bebianno et al, 2007); in hepatopancreas tissues of the crustacean Macrobrachium borellii (Lavarías et al, 2011); in the polychaete Arenicola marina (Ramos-Gómez et al, 2011a) and in digestive glands tissues of Mytilus edulis exposed to polycyclic aromatic hydrocarbons (Solé et al, 1996).…”

Section: Discussionmentioning

confidence: 86%

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General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals

Aguirre-Martínez

DelValls

Martı́n-Dı́az

2016

Ecotoxicology and Environmental Safety

118

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Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 86%

General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals

Aguirre-Martínez

DelValls

Martı́n-Dı́az

2016

Ecotoxicology and Environmental Safety

118

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“…To study the effects of endosulfan on the activity ethoxyresorufin-O-deethylase (EROD), glutathione-Stransferase (GST), superoxide dismutase (SOD), glutathione content, lipid peroxidation (LPO) and DNA strand break in gills and digestive glands of Ruditapes philippinarium (clams), they were exposed to 0.005, 0.05 and 0.5µg/L endosulfan for 15 days [26]. The exposure resulted in the increase of EROD, GST, GSH, while SOD was seen to decrease.…”

Section: Toxicity Among Aquatic Organismsmentioning

confidence: 99%

Toxic Effects of Organochlorine Pesticides: A Review

Singh¹

2016

AJBIO

100

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This study is aimed at compiling the toxicological aspects of organochlorine compounds (OCCs) including pesticides among different animal models. Tests on animal species like Mean Probable Effect Concentration Quotient (PEC-Q) test, DNA repair assays and histopathological examinations have shown positive results for the toxicity of organochlorine pesticides. The results were observed on different animals including fishes, furseals, frogs, rats, bats and humans. In fishes, endosulfan is found to have acute toxicities. Similarly, organophosphorus, synthetic pyrethroids and microbial insecticides were also found to show their toxic effects. Some compounds such as lambda-cyhalothrin showed a very high toxicity on fish followed by fenvalerate, deltamethrin and cypermethrin. Exposure to OCCs can impart foe cell death by inducing Mitogen Activated Protein Kinase Pathway (MAPK) which is associated with cell growth differentiation and apoptosis. On studying the genotoxic effects of OCCs on germ cells of mouse, it was observed that a lethal mutation can occur just after one mating interval. Increase in the number of micronucleated cells has also been seen after OCC exposure. Neuro-behavioural studies on rats showed the presence of tremors caused by chlordecone and p,p'DDT. Tumorigenicity by organochlorine pesticides is seen to be an epigenetic mechanism in a DNA repair assay. Acute poisoning was seen in liver, kidney and testis of albino rat due to the toxic effect of dursban and DDT. Great declines in populations have been seen due to OCC toxicity in different animal species. Direct and indirect exposure to these compounds should be reduced so as to minimize the possible health hazards.

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“…The half-lives of DDT and HCH in surface soil were estimated as 6.7 and 4.9 years, respectively (Brevik et al 1996;Toan et al 2009). The impact of OCPs in aquatic organisms is more important than that of organophosphorus pesticides and considered really alarming (Alava et al 2011;Tao et al 2013) because OCP contents were higher (Serrano et al 1999;Hernández et al 2000;Fatta et al 2007). We choose to determine the OCP contents, the first generation of pesticides, because of their persistence in the environment and their alarming impact on aquatic organisms, estimating, thus, the old contamination in the Ichkeul LakeBizerta Lagoon complex.…”

Section: Pesticide Usementioning

confidence: 97%

Pesticides in Ichkeul Lake–Bizerta Lagoon Watershed in Tunisia: use, occurrence, and effects on bacteria and free-living marine nematodes

Salem

Saïd

Aïssa

et al. 2015

Environ Sci Pollut Res

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This study aimed to identify the most commonly used agricultural pesticides around Ichkeul Lake-Bizerta Lagoon watershed. First survey of pesticide use on agricultural watershed was performed with farmers, Regional Commissioner for Agricultural Development, and pesticide dealers. Then, sediment contamination by pesticides and response of benthic communities (bacteria and free-living marine nematode) were investigated. The analysis of 22 active organochlorine pesticides in sediments was performed according to quick, easy, cheap, effective, rugged, and safe (QuEChERS) method, biodiversity of indigenous bacterial community sediment was determined by terminal restriction fragment length polymorphism (T-RFLP), and free-living marine nematodes were counted. The results of the field survey showed that iodosulfuron, mesosulfuron, 2,4-dichlorophenoxyacetic acid (2,4 D), glyphosate, and fenoxaprops were the most used herbicides, tebuconazole and epoxiconazole the most used fungicides, and deltamethrin the most used insecticide. Sixteen organochlorine pesticide compounds among the 22 examined were detected in sediments up to 2 ppm in Ichkeul Lake, endrin, dieldrin, and hexachlorocyclohexane being the most detected molecules. The most pesticide-contaminated site in the lake presented the higher density of nematode, but when considering all sites, no clear correlation with organochlorine pesticide (OCP) content could be established. The bacterial community structure in the most contaminated site in the lake was characterized by the terminal restriction fragments (T-RFs) 97, 146, 258, 285, and 335 while the most contaminated site in the lagoon was characterized by the T-RFs 54, 263, 315, 403, and 428. Interestingly, T-RFs 38 and 143 were found in the most contaminated sites of both lake and lagoon ecosystems, indicating that they were resistant to OCPs and able to cope with environmental fluctuation of salinity. In contrast, the T-RFs 63, 100, 118, and 381 in the lake and the T-RFs 40, 60, 80, 158, 300, 321, and 357 in the lagoon were sensitive to OCPs. This study highlighted that the intensive use of pesticides in agriculture, through transfer to aquatic ecosystem, may disturb the benthic ecosystem functioning of the protected area. The free-living marine nematodes and bacterial communities represent useful proxy to follow the ecosystem health and its capacity of resilience.

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Assessment of the toxicity of organochlorine pesticide endosulfan in clams Ruditapes philippinarum

Cited by 55 publications

References 54 publications

General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals

General stress, detoxification pathways, neurotoxicity and genotoxicity evaluated in Ruditapes philippinarum exposed to human pharmaceuticals

Toxic Effects of Organochlorine Pesticides: A Review

Pesticides in Ichkeul Lake–Bizerta Lagoon Watershed in Tunisia: use, occurrence, and effects on bacteria and free-living marine nematodes

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