Assessment of the Toxicity of Artemisia inculta Extract on the Bone Marrow of Mice Infected with Schistosomiasis

Lotfy, Abeya A M; Ghanem, Lobna Y; Shennawy, Amal M; Gomaa, Nadia A; El-Said, Hamda H

doi:10.1055/s-0031-1296709

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Cited by 2 publications

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“…In Egypt,A. inculta also was reportedly used in a mouse model against bilharzia (Lotfy et al, 2006). Infected mice were orally gavaged with an ethanol extract of the plant at a dose of 800 mg/kg.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial

Munyangi¹,

Cornet-Vernet²,

Idumbo³

et al. 2018

Phytomedicine

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial

Munyangi¹,

Cornet-Vernet²,

Idumbo³

et al. 2018

Phytomedicine

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Effects of Artemisia princeps supplementation on bone metabolism in ovariectomized rats

Kim

Park

2016

The Journal of nutrition, health and aging

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The aim of this study was to investigate the effects of Artemisia princeps (AP) extract on bone metabolism and its potential role in the prevention of osteoporosis in ovariectomized rats. Twenty-six female Sprague-Dawley rats were divided into five groups and treated as follows: sham-operated control group (SHAM); ovariectomized control group (OVX), ovariectomized group treated by gavage with 10 mg/kg/day alendronate (ALEN); ovariectomized group treated by gavage with 100 mg/kg/day Artemisia princeps (AP100); ovariectomized group treated by gavage with 300 mg/kg/day Artemisia princeps (AP300). Treatment of ovariectomized rats with AP extracts for 15 weeks prevented the reduction in bone thickness and trabecular bone mineral density caused by urinary Ca and Cr excretion, and also prevented the increase in bone turnover by maintaining the serum Ca/P ratio. As a result, the microarchitecture of the trabecular bone and cortical bone after ovariectomy was markedly improved by administration of AP extracts. In conclusion, AP prevented bone loss and osteoclast activity associated with high bone turnover in ovariectomized rats by controlling the serum Ca/P ratio and through anti-inflammatory and anti-oxidant properties. Our data implicate AP as a promising therapeutic option for the improvement of postmenopausal osteoporosis.

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Assessment of the Toxicity of Artemisia inculta Extract on the Bone Marrow of Mice Infected with Schistosomiasis

Abstract: Electron microscopy has provided a direct and accurate evidence of the nontoxic property of the plant extract on bone marrow using therapeutic doses. However, this study should be extended to other vital organs such as the liver or brain to establish the safety of this drug.

Cited by 2 publications

References 7 publications

RETRACTED: Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial

RETRACTED: Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial

Effects of Artemisia princeps supplementation on bone metabolism in ovariectomized rats

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