Assessment of the toxicological profile of Chlorella (C. vulgaris) powder by performing acute and sub-acute oral toxicity studies in mice

Yadav, Mahendra Singh; Sharma, Pooja; Kushwah, Himanshu; Sandal, Nidhi; Chauhan, Meenakshi

doi:10.1007/s10811-021-02632-8

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Evaluating dietary agents that can effectively modulate immune function is critical for implementing dietary interventions for managing immune disorders. Regarding the biological safety and toxicity of CV, it is reported that no acute toxicity was detected in mice treated with 2000 mg/kg of CV [42]. Our current study demonstrated that during homeostasis, CV administration induced the systemic expansion of Treg cells with a concomitant increase in the MFI of Foxp3, which is often associated with the higher suppressive activity of Tregs.…”

Section: Discussionsupporting

confidence: 51%

Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice

Velankanni

Jin

et al. 2023

Nutrients

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Chlorella vulgaris (C. vulgaris) is unicellular green algae consumed worldwide as a functional food. The immune stimulatory function of C. vulgaris is known; however, no study has elucidated its immune regulatory potential and associated microbiome modulation. In the current study, we aimed to validate the immune regulatory role of C. vulgaris mediated through two mechanisms. Initially, we assessed its ability to promote the expansion of the regulatory T cell (Treg) population. Subsequently, we investigated its impact on gut microbiota composition and associated metabolites. The supplementation of C. vulgaris altered the gut microbiota composition, accompanied by increased short-chain fatty acid (SCFAs) production in mice at homeostasis. We later used C. vulgaris in the treatment of a DSS-induced colitis model. C. vulgaris intervention alleviated the pathological symptom of colitis in mice, with a corresponding increase in Treg levels. As C. vulgaris is a safe and widely used food supplement, it can be a feasible strategy to instigate cross-talk between the host immune system and the intestinal flora for the effective management of inflammatory bowel disease (IBD).

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Section: Discussionsupporting

confidence: 51%

Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice

Velankanni

Jin

et al. 2023

Nutrients

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“…It was documented by the FDA as safe for human consumption (9). Moreover, according to a previous published study, male and female mice dosed orally with acute and repeated doses of chlorella demonstrated no toxicity or adverse effects at levels estimated at 1,000 mg/kg −1 body weight per day and did not die during the period of investigation (10). Available commercially, chlorella products contain nutrients essential for humans (notably, vitamin D2 and B12), high amounts of high-quality protein, dietary fiber, and polyunsaturated fatty acids (including α-linoleic and linoleic acids) (1,11,12).…”

Section: Introductionmentioning

confidence: 84%

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Chou

Huang

et al. 2022

Front. Nutr.

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Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural materials is an urgent need. Therefore, this study used a complex extract of chlorella and lion's mane mushroom and evaluated its antidepressant effects. Six-month-old male senescence-accelerated mice prone-8 (SAMP8) were divided into positive control; negative control; and low, medium, and high-dose groups. All groups were treated with corticosterone (CORT) at 40 mg/Kg/day for 21- days to induce depression in the animals, and the effects of different test substances on animal behavior was observed. The positive control group was intraperitoneally injected with a tricyclic antidepressant (Fluoxetine, as tricyclic antidepressant), the control group was given ddH2O, and the test substance groups were administered test samples once daily for 21 days. The open field test (OFT) and forced swimming test (FST) were applied for behavior analyses of depression animal models. The OFT results showed that the mice in the positive control and the medium-, and high-dose groups demonstrated a significantly prolonged duration in the central area and a significantly increased travel distance. In the FST, the positive control and the medium, and high-dose groups displayed significantly reduced immobility times relative to the control group. The blood analysis results showed significant decreases in triglyceride and blood urea nitrogen levels relative to the positive control and the medium- and high-dose groups. Notably, in the positive control and the medium- and high-dose groups, brain-derived neurotrophic factor (BDNF) increase by more than in the control group. In summary, medium and high dose of extract of chlorella and lion's mane mushroom could improve depression behavior in animals and have the potential to be antidepressant health care products.

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Lead: Exposure Risk, Bio Assimilation and Amelioration Strategies in Livestock Animals

Singh¹,

Mahesh²,

Ojha

et al. 2023

Environmental Science and Engineering

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Assessment of the toxicological profile of Chlorella (C. vulgaris) powder by performing acute and sub-acute oral toxicity studies in mice

Cited by 6 publications

References 35 publications

Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice

Chlorella vulgaris Modulates Gut Microbiota and Induces Regulatory T Cells to Alleviate Colitis in Mice

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Lead: Exposure Risk, Bio Assimilation and Amelioration Strategies in Livestock Animals

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