Assessment of the Value of the Antacid Contents of Selected Palestinian Plants

Houshia, Orwa Jaber; AbuEid, Mohamad; Zaid, Oday; Zaid, Motasem; Al-daqqa, Najat

doi:10.5923/j.chemistry.20120206.05

Cited by 10 publications

(8 citation statements)

References 4 publications

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Section: Antacid Ingredients: Mechanisms To Clinical Evidencementioning

confidence: 99%

“…Non-absorbable antacids such as aluminum hydroxide, aluminum phosphate, calcium carbonate, and magnesium hydroxide are not absorbed to a significant extent; e.g., only 15% to 30% of calcium and 5% to 10% of magnesium are absorbed from their respective antacid formulations. [54][55][56] Each antacid ingredient has a unique mechanism with the ultimate goal of acid neutralization (Figure 1). Ingredients with different features and limitations provide options to physicians for addressing the intra-and intersubject variability of patients.…”

Section: Antacid Ingredients: Mechanisms To Clinical Evidencementioning

confidence: 99%

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Antacids revisited: review on contemporary facts and relevance for self-management

Sangwan¹,

Narang²,

Taneja³

2022

J Int Med Res

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Heartburn and acid regurgitation are the typical symptoms of gastroesophageal reflux. Despite the availability of several treatment options, antacids remain the mainstay treatment for gastroesophageal reflux-related symptoms based on their efficacy, safety, and over-the-counter availability. Antacids are generally recommended for adults and children at least 12 years old, and the FDA recommends antacids as the first-line treatment for heartburn in pregnancy. This narrative review summarizes the mechanism, features, and limitations related to different antacid ingredients and techniques available to study the acid neutralization and buffering capacity of antacid formulations. Using supporting clinical evidence for different antacid ingredients, it also discusses the importance of antacids as OTC medicines and first-line therapies for heartburn, particularly in the era of the COVID-19 pandemic, in which reliance on self-care has increased. The review will also assist pharmacists and other healthcare professionals in helping individuals with heartburn to make informed self-care decisions and educating them to ensure that antacids are used in an optimal, safe, and effective manner.

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Section: Antacid Ingredients: Mechanisms To Clinical Evidencementioning

confidence: 99%

Section: Antacid Ingredients: Mechanisms To Clinical Evidencementioning

confidence: 99%

Antacids revisited: review on contemporary facts and relevance for self-management

Sangwan¹,

Narang²,

Taneja³

2022

J Int Med Res

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“…The causes of peptic ulcer is unclear in most of the patients, generally accepted that it may results of imbalance between aggressive factors and the maintenance of mucosal integrity through the endogenous protection system [7]. Acidity is a common gastrointestinal problem due to excessive secretion of gastric acid or stomach acid inflames the stomach lining mucosa and produces ulceration [8]. Antacids act by neutralizing gastric acid and thereby reduce the gastric pH [9].…”

Section: Resultsmentioning

confidence: 99%

In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

et al. 2020

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Medicinal plants have been known for millennia as a rich source of traditional therapeutic agents for the prevention of diseases and ailments. The aim of the present study was performed to evaluate the antiulcer activities of hydro-alcoholic extracts of petals of Crocus sativus var. Cashmerianus by in-vitro methods viz. acid neutralizing capacity and H+/K+ - ATPase inhibition activity. In acid neutralizing capacity method, the petals extract significantly reduced acidity to 6.10 at a concentration of 1000 mg/ml as compared to 11.90 with standard 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide combination. However, H+/K+ - ATPase inhibition activity method, petals extract showed maximum percentage inhibition of 70.31 % at the concentration 400µg/ml as compared to 73.82 % with a similar dose of standard Omeprazole. The IC 50 value of petals extract of C. sativus var. cashmerianus is shown 100 µg/ml in comparison with standard omeprazole of 82.5 µg/ml. The study reveals that the petals extract of C. sativus var. cashmerianus may contain compounds possessing acid neutralize and enzyme inhibition activities, thus it can be used as an alternative medicine for gastrointestinal disorders.

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“…Excessive secretion of gastric acid or stomach acid (i.e., HCl), inflames the stomach lining and produces ulceration (27).Antacids act by neutralizing gastric acid and thereby reduce the gastric pH. The regain balance is maintained for the use of therapeutic agents differently for the use of gastric acid secretion inhibition or by increasing the mucosal production to boost the mucosal defense mechanism by stabilizing the surface epithelial cells or inhibition of prostaglandin synthesis (28).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anti-Ulcer Activity Of Vempam Poo (Flower Of Azadirachta Indica) Ooral Kudineer – Siddha Herbal Drug

Revathy S

et al. 2024

eatp

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In this expeditious world, Peptic Ulcer is one of the commonest problems seen among the world population. Peptic Ulcer Disease (PUD) is a global problem with a lifetime risk of development ranging from 5% to 10% (1, 2). Peptic ulcers are acid-induced lesions found in the stomach and duodenum characterized by denuded mucosa with the defect extending into the submucosa or muscularis propria(3). In some cases, peptic ulcer can be life threatening with symptoms like bloody stool, severe abdominal pain, and cramps along with vomiting blood (4). The pathophysiology of peptic ulcer disease involves an imbalance between offensive (acid, pepsin, and Helicobacter pylori) and defensive factors (mucin, prostaglandin, bicarbonate, nitric oxide, and growth factors) (5). Peptic ulcer disease (PUD) has various causes includes Helicobacter pylori-associated PUD and NSAID-associated PUD account for the majority of the disease etiology (6). Eating spicy food substances increase the symptoms of ulcers; the other symptoms include nausea, vomiting, and weight loss. Although patients with gastric ulcers have normal or diminished acid production, yet ulcers may occur even in the complete absence of acid (7). The prevalence of Peptic ulcers is increasing among the population due to the unhealthy food habits of the people (8). Recently, considerable attention has been paid to utilize plant based products for the prevention and cure of various diseases. It is documented by WHO that 80% of the world's population has faith in traditional medicine, particularly plant drugs for their primary healthcare (9).

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Assessment of the Value of the Antacid Contents of Selected Palestinian Plants

Cited by 10 publications

References 4 publications

Antacids revisited: review on contemporary facts and relevance for self-management

Antacids revisited: review on contemporary facts and relevance for self-management

In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

In Vitro Anti-Ulcer Activity Of Vempam Poo (Flower Of Azadirachta Indica) Ooral Kudineer – Siddha Herbal Drug

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