Assessment of Toxicologic Effects upon Bone Marrow and Related Tissues

Kociba, R.J.; Kociba, Gary J.

doi:10.1007/978-3-642-84110-1_11

Hemopoietic System

1990

DOI: 10.1007/978-3-642-84110-1_11

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Assessment of Toxicologic Effects upon Bone Marrow and Related Tissues

R.J. Kociba¹,

Gary J. Kociba²

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Cited by 2 publications

(1 citation statement)

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“…Since the bone marrow, the lymph nodes, the spleen and the thymus should be considered as a single system, 13) we performed an integrated, simultaneous morphologic evaluation of these organs.…”

mentioning

confidence: 99%

Thymic lymphomas in Wistar rats exposed to N‐methyl‐N‐nitrosourea (MNU)

Franchi¹,

Bacchi²,

Padovani

et al. 2003

Cancer Science

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The Brazilian Agency for the Environment (IBAMA) recently adopted an alternative medium-term multiple-organ assay system with the Wistar rat strain for detection of the carcinogenic potential of pesticides. Originally, this initiation-promotion protocol was established in Japan with the isogenic Fischer 344 male rat. Among the initiating agents used in that assay, N-methyl-Nnitrosourea (MNU) rapidly induces malignant lymphoma and leukemia and early mortality of rats from different strains. This study was developed to evaluate whether the outbred Wistar rats are also similarly susceptible to MNU. Particularly, it aimed to evaluate the dose-response relationship and to register the MNUinduced pre-neoplasia and neoplasia that may develop in the lympho-hematopoietic system ( he standard experimental procedure for detection of the carcinogenic potential of chemicals is the long-term bioassay with rats and mice.

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mentioning

confidence: 99%

Thymic lymphomas in Wistar rats exposed to N‐methyl‐N‐nitrosourea (MNU)

Franchi¹,

Bacchi²,

Padovani

et al. 2003

Cancer Science

View full text Add to dashboard Cite

show abstract

Age-related incidence of spontaneous non-neoplastic lesionsin a colony of Han:AURA hamsters

Kamino

Tillmann

Boschmann

et al. 2001

Experimental and Toxicologic Pathology

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Assessment of Toxicologic Effects upon Bone Marrow and Related Tissues

Cited by 2 publications

References 11 publications

Thymic lymphomas in Wistar rats exposed to N‐methyl‐N‐nitrosourea (MNU)

Thymic lymphomas in Wistar rats exposed to N‐methyl‐N‐nitrosourea (MNU)

Age-related incidence of spontaneous non-neoplastic lesionsin a colony of Han:AURA hamsters

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