Assessment of Tumor Radioresponsiveness and Metastatic Potential by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Øvrebø, Kirsti Marie; Gulliksrud, Kristine; Mathiesen, Berit; Rofstad, Einar K.

doi:10.1016/j.ijrobp.2011.04.008

Cited by 23 publications

(17 citation statements)

References 26 publications

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“…They clarified that the mice with metastatic tumours had significantly lower K trans values than did the metastasis-negative mice, consistent with the hypothesis that hypoxia promotes lymph node metastasis. 28 They also demonstrated that the K trans , but not the v e , was associated with the metastatic potential of the tumour. 28 We found that the progression of N stage was associated with a decrease of the K trans , consistent with the results obtained in animal experiments.…”

Section: Discussionmentioning

confidence: 97%

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Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: a preliminary study of the correlations between quantitative parameters and the clinical stage

Chikui

Kitamoto

Kami

et al. 2015

BJR

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Section: Discussionmentioning

confidence: 97%

“…28 They also demonstrated that the K trans , but not the v e , was associated with the metastatic potential of the tumour. 28 We found that the progression of N stage was associated with a decrease of the K trans , consistent with the results obtained in animal experiments.…”

Section: Discussionmentioning

confidence: 97%

Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: a preliminary study of the correlations between quantitative parameters and the clinical stage

Chikui

Kitamoto

Kami

et al. 2015

BJR

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“…The final outcome was shown by decreased vascularity within the microenvironment of irradiated tumor as reflected by decreased MVCs. However, divergent conclusions, primarily regarding baseline and change in K trans , were proposed by other studies using different treatment modalities and cancer types [26], [27], [28]. The dominant MRI findings might vary between animal xenografts and patients, and between different malignancies [13].…”

Section: Discussionmentioning

confidence: 99%

Early Detection of Lewis Lung Carcinoma Tumor Control by Irradiation Using Diffusion-Weighted and Dynamic Contrast-Enhanced MRI

et al. 2013

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PurposeTo investigate the correlation between diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) derived parameters and radioresponsiveness of Lewis lung carcinoma (LLC) tumor.Materials and MethodsLLC tumor growth in C57BL/6 mouse limb was used for the experiment. The tumors were irradiated with 10 Gy×5, or 30 Gy×2 vs. sham irradiation. Fourteen tumors were subjected to DW-MRI and DCE-MRI pre-radiotherapy and weekly imaging after radiotherapy. The temporal changes in apparent diffusion coefficient (ADC) and DCE-MRI derived parameters (Ktrans, kep, ve, and vp) were correlated with tumor size, and were histologically compared with CD31 staining of resected tumors.ResultsThe 10 Gy×5 dose inhibited tumor growth for a week, while 30 Gy×2 controlled tumor growth for a 3-week observation period. One week after radiotherapy (week 2), irradiated tumors showed significantly higher values of ADC than untreated ones (10 Gy×5, p = 0.004; 30 Gy×2, p = 0.01). Significantly higher values of ve were shown earlier by 30 Gy×2 vs. sham (p = 0.01) and 10 Gy×5 vs. sham irradiation (p = 0.05). Sustained higher ve from 10 Gy×5 compared to sham irradiated tumors was evident at week 3 (p = 0.016) and week 4 (p = 0.046). A 13.8% early increase in ADC for 30 Gy×2 tumor group (p = 0.002) and a 16.5% increase for 10 Gy×5 group were noted (p = 0.01) vs. sham irradiation (which showed a 2.2% decrease). No differences were found for Ktrans, kep, or vp. Both radiotherapy groups demonstrated significant reduction in microvessel counts.ConclusionEarly increase in ADC and ve correlated with tumor control by irradiation.

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“…It has therefore been suggested that DCE-MRI could be used as an indirect method to detect hypoxic areas in tumors. In a recent preclinical study by Øvrebø and colleagues, k trans was found to be predictive of tumor response to radiotherapy: low k trans was associated with an increased radioresistance in hypoxic melanoma xenografts, suggesting that DCE-MRI is a biomarker of tumor radioresistance in hypoxic tumors (78). Further studies on two cervical cancer xenografts have confirmed those results, indicating that the radiotherapy outcome can be correlated with k trans values measured before the treatment taking each tumor model separately (79).…”

Section: Mri Methodsmentioning

confidence: 99%

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

2017

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Tumor hypoxia is recognized as a limiting factor for the efficacy of radiotherapy, because it enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation could help to predict the outcome of cancer patients undergoing radiation therapy. Strategies have also been developed to alleviate tumor hypoxia in order to radiosensitize tumors. In addition, oxygen mapping is critically needed for intensity modulated radiation therapy (IMRT), in which the most hypoxic regions require higher radiation doses and the most oxygenated regions require lower radiation doses. However, the assessment of tumor oxygenation is not yet included in day-to-day clinical practice. This is due to the lack of a method for the quantitative and non-invasive mapping of tumor oxygenation. To fully integrate tumor hypoxia parameters into effective improvements of the individually tailored radiation therapy protocols in cancer patients, methods allowing non-invasively repeated, safe, and robust mapping of changes in tissue oxygenation are required. In this review, non-invasive methods dedicated to assessing tumor oxygenation with the ultimate goal of predicting outcome in radiation oncology are presented, including positron emission tomography used with nitroimidazole tracers, magnetic resonance methods using endogenous contrasts (R1 and R2*-based methods), and electron paramagnetic resonance oximetry; the goal is to highlight results of studies establishing correlations between tumor hypoxic status and patients’ outcome in the preclinical and clinical settings.

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Assessment of Tumor Radioresponsiveness and Metastatic Potential by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Cited by 23 publications

References 26 publications

Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: a preliminary study of the correlations between quantitative parameters and the clinical stage

Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: a preliminary study of the correlations between quantitative parameters and the clinical stage

Early Detection of Lewis Lung Carcinoma Tumor Control by Irradiation Using Diffusion-Weighted and Dynamic Contrast-Enhanced MRI

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

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