2008
DOI: 10.1016/j.fertnstert.2007.08.086
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Assessment of vascular endothelial growth factor expression and apoptosis in the ovarian graft: can exogenous gonadotropin promote angiogenesis after ovarian transplantation?

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Cited by 82 publications
(103 citation statements)
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“…According to previous data, the increased VEGF expression in the grafted ovaries appeared 2 days after transplantation [32], which is also the critical time that the total follicle pool was reduced and the area of the grafted tissue was non-reversibly damaged. In ovarian graft transplantation,VEGF is one of the most important factors for rapid establishment of rich blood supply, which is crucial for the survival of the ovarian follicles.…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…According to previous data, the increased VEGF expression in the grafted ovaries appeared 2 days after transplantation [32], which is also the critical time that the total follicle pool was reduced and the area of the grafted tissue was non-reversibly damaged. In ovarian graft transplantation,VEGF is one of the most important factors for rapid establishment of rich blood supply, which is crucial for the survival of the ovarian follicles.…”
Section: Discussionmentioning
confidence: 62%
“…Therefore we incubated the ovarian tissues with VEGF, bFGF or both before transplantation, and hypodermically injected them at transplant site 7 days after transplantation, for directly and steadily absorption in the critical period of graft vascularization. From day 7 and on, the grafts were perfused by functional vasculature [32].…”
Section: Discussionmentioning
confidence: 99%
“…13 After transplantation, vascular endothelial growth factor (VEGF) transcription in the graft is upregulated due to hypoxia. Within the ovary, VEGF infusion 14 or exogenous gonadotropin administration 15 after ovarian grafting in primates failed to improve graft function and follicle survival. However, the controlled release of VEGF from biomaterials has been effective in other systems to promote angiogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…A hipótese vigente, atualmente, é de que há maior perda folicular em decorrência da isquemia sofrida durante o preparo e o transplante do que pelo eventual dano produzido pela criopreservação (11,53) .…”
Section: Análise Inferencialunclassified
“…Adaptado de Oktay (9) Câncer em crianças Embora as alternativas hoje existentes de preservar a fertilidade em mulheres jovens sujeitas à perda da capacidade reprodutiva sejam consideradas boa prática médica, a retirada e a conservação de tecido ovariano ainda são consideradas procedimento experimental (54)(55)(56) . Várias dúvidas persistem quanto ao método com melhores e mais seguros resultados (46) : ainda é necessário estabelecer, com segurança, qual a diferença entre as técnicas mais relatadas; a viabilidade do transplante autólogo e heterólogo; a influência da criopreservação e do local de reimplante nas taxas de morte celular e qual a aplicabilidade, na espécie humana, das diversas técnicas e táticas descritas em estudos com animais de laboratório (57) .…”
Section: Análise Inferencialunclassified