Assessment of Vitamin B-6 Status in Young Women Consuming a Controlled Diet Containing Four Levels of Vitamin B-6 Provides an Estimated Average Requirement and Recommended Dietary Allowance

Hansen, Christine M.; Shultz, Terry D.; Kwak, Ho‐Kyung; Memon, Haris; Leklem, James E.

doi:10.1093/jn/131.6.1777

Cited by 47 publications

(58 citation statements)

References 37 publications

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“…[23][24][25] However, despite the good mean intake figures recorded, at the beginning of the study 12.3% of the women showed PLP values of o25 nmol l À1 , the lower normal limit established by some authors 26 (Table 3). Such a situation can worsen when women follow unbalanced diets, and many women who are concerned about their weight frequently follow restrictive, poorly controlled diets, 5 and run the risk of negatively affecting their vitamin status.…”

Section: Discussionmentioning

confidence: 85%

Vitamin B6 status improves in overweight/obese women following a hypocaloric diet rich in breakfast cereals, and may help in maintaining fat-free mass

et al. 2008

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Objective: To analyze the changes in vitamin B 6 status in women following slightly hypocaloric diets based on the relative increase consumption of foods whose intakes are below those recommended, and to study how these changes influence the proportion of fat-free mass. Design: Intervention study of two slightly hypocaloric diets: diet V (increased consumption of vegetables), or diet C (increased consumption of cereals, especially breakfast cereals). Subjects: A total of 49 women with a body mass index (BMI) of 25-35 kg/m 2 . Measurements: Dietetic, anthropometric and biochemical data were collected at the start of the study and at 2 and 6 weeks. Results: Both the C and V subjects showed a reduction in their energy intake, body weight, BMI and fat mass. Pyridoxine intake increased in both groups and plasma pyridoxal phosphate (PLP) levels increased only with diet C. An association was found between the increase in plasma PLP at 6 weeks and the increase in pyridoxine intake (r ¼ 0.451; Po0.01). Multiple regression analysis showed a positive association between the increase in PLP at the end of the study and the increases in the pyridoxine intake, B 6 density or B 6 /protein ratio. At the end of the study, and only in those women whose PLP levels were increased, the higher the increase in PLP level, the higher the increase in fat-free mass percentage (r ¼ 0.4426, Po0.05) Conclusions: Interventions aimed at weight control should also try to maintain or improve nutritional status. A diet rich in cereals (especially fortified breakfast cereals) appears to be useful in improving vitamin B 6 status. Such an improvement could help maintain fat-free mass during periods of weight loss.

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Section: Discussionmentioning

confidence: 85%

Vitamin B6 status improves in overweight/obese women following a hypocaloric diet rich in breakfast cereals, and may help in maintaining fat-free mass

et al. 2008

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“…Thiamin hydrochloride (C12H17ClN4OS-HCl; MW5337.27), riboflavin (C17H20N4O65376. 37 Determination of vitamins and metabolites in urine. For analysis of thiamin, 1 mL of 1 mol/L HCl was added to 9 mL of urine.…”

Section: Methodsmentioning

confidence: 99%

“…Among the evaluation of the vitamin B6 nutritional status, plasma PLP is considered the most relevant, but measurement of urinary 4-PIC, which is the major end product of vitamin B6 metabolism, also is recommended (37,38). Increased elimination of 4-PIC means a surplus intake of vitamin B6 above the necessary level of vitamin B6.…”

Section: Vitamin B6mentioning

confidence: 99%

Urinary Excretion Levels of Water-Soluble Vitamins in Pregnant and Lactating Women in Japan

Shibata

Fukuwatari

Sasaki

et al. 2013

J Nutr Sci Vitaminol

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Dietary habits of pregnant and lactating women have a critical impact on the health of future infants. For this reason, the Japanese Dietary Reference Intakes regarding the amounts of addition of water-soluble vitamins have been set (1). The additional intake amounts for pregnant and lactating women were calculated based on data concerning the changes in the metabolic characteristics of vitamins in pregnant women and the loss of vitamins as a result of lactation. However, there is little information about whether nutritional statuses of water-soluble-vitamins in Japanese pregnant and lactating women are good or not. Therefore, we examined the nutritional status of pregnant and lactating women and speculated about the validity of the additional amount of some water-soluble vitamins in the dietary reference intakes for pregnant and lactating women.A potential approach for determining the validity for the additional amounts is based on the observation that a water-soluble vitamin or its catabolite(s) can be detected in the urine (2-11). Using this approach, the urinary excretion of a water-soluble vitamin or its catabolite(s) occurs when the dietary intake exceeds an individual necessary amount. MATERIALS AND METHODSSubjects. Japanese pregnant (16-40 wk gestation) or lactating women (0-11 mo postpartum) were recruited from a parenting circle in The University of Shiga Prefecture between April 2010 and February 2012. Japanese married non-pregnant, non-lactating women also were recruited as controls through the parenting circle to match the mean ages and heights of the pregnant and lactating women. The purpose and protocol of this study was explained to all participants before joining the study, and written informed consent was obtained from each participant. We excluded participants diagnosed with a cold or influenza, and those who had taken multi-vitamin supplements at least once during the previous month. In addition, we excluded participants whose 24-h urine collection was considered incomplete: a collection time outside the 22-26-h range, urine volume ,250 mL, or extremely low or high energy intake (,500 or .4,000 kcal/d) (12). Twenty-four of the 2nd trimester pregnant (16-27 wk gestation) and 32 of the Bunkyo-ku, Tokyo 113-0033, Japan (Received December 17, 2012) Summary Recent studies have shown that the urinary excretion levels of water-soluble vitamins can be used as biomarkers for the nutritional status of these vitamins. To determine changes in the urinary excretion levels of water-soluble vitamins during pregnant and lactating stages, we surveyed and compared levels of nine water-soluble vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n537), women in the 2nd (16-27 wk, n524) and 3rd trimester of pregnancy (over 28 wk, n532), and early-(0-5 mo, n554) and late-stage lactating (6-11 mo, n549) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the comple...

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“…In this review, three of the four papers on intake-status relationship did indeed use more than three indicators to assess vitamin B6 status (Hansen et al 2001, Huang et al 1998, Kretsch et al 1995. In addition, most papers on the association between status indicators of vitamin B6 and certain health outcomes used plasma PLP, which is generally accepted as the best indicator for vitamin B6 status.…”

Section: Intake-statusmentioning

confidence: 93%

“…In the study of Hansen et al, recommendations for vitamin B6 intake were assessed based on the effect of vitamin B6 intake and the dietary vitamin B6 to protein ratio on several vitamin B-6 status indicators in plasma, erythrocytes and urine of young women (Hansen et al 2001). Seven healthy young women consumed a controlled diet providing 1.2 g protein/kg body weight for a 7-d adjustment period (1.0 mg vitamin B-6/d) and three successive 14-d experimental periods (1.5, 2.1 and 2.7 mg/d).…”

Section: Depletion-repletion Studiesmentioning

confidence: 99%

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Niacin, Biotin and Vitamin B6

Eeuwijk¹,

Oordt²,

Terzikhan³

et al. 2012

EFSA Supporting Publications

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Assessment of Vitamin B-6 Status in Young Women Consuming a Controlled Diet Containing Four Levels of Vitamin B-6 Provides an Estimated Average Requirement and Recommended Dietary Allowance

Cited by 47 publications

References 37 publications

Vitamin B6 status improves in overweight/obese women following a hypocaloric diet rich in breakfast cereals, and may help in maintaining fat-free mass

Vitamin B6 status improves in overweight/obese women following a hypocaloric diet rich in breakfast cereals, and may help in maintaining fat-free mass

Urinary Excretion Levels of Water-Soluble Vitamins in Pregnant and Lactating Women in Japan

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Niacin, Biotin and Vitamin B6

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