Assessment of Vitamin B12 Status in Patients with Morbid Obesity

Alkhawtani, Daniyah Abdullah

doi:10.15406/aowmc.2017.06.00181

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…17 Helicobacter pylori infection is more common in obese patient, it may cause food cobalamin malabsorption (FCM). [18][19] FCM is the inability to split cobalamin from food or other binders. 17 Also obesity may cause increase catabolism and sequestration of vitamin B 12 in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine, vitamin B<sub>12</sub> and folic acid levels in metabolic syndrome

Nurjahan

Akter

Begum

2020

J Bangladesh Soc Physiol

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Background: Metabolic syndrome (MeS) is a risk factor for cardiovascular disease, chronic lung disease, fatty liver disease and kidney disease. Elevated serum homocysteine level is an independent risk factor for cardiovascular disease and lung disease. Vitamin B12 and folic acid deficiency causes hyperhomocysteinemia. Objective: To measure serum homocysteine, vitamin B12 and folic acid levels in metabolic syndrome. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from March 2019 to February 2020. Total 30 female metabolic syndrome patients aged 25 to 45 years and 30 age and sex matched apparently healthy female subjects were enrolled for this study. The patients were selected from the outpatient department of Endocrinology of BSMMU. Fasting plasma glucose, lipid profile, serum creatinine, serum alanine aminotransferase levels were measured by autoanalyzer and serum homocysteine, vitamin B12 and folic acid levels were measured by Chemiluminescent immunoassay. For statistical analysis, independent sample ‘t’test was done. Results: In this study, the mean value of serum homocysteine level was significantly higher in MetS than those of control group (p value <0.05). In addition, 16.67% MetS patients had hyperhomocysteinemia. Conclusion: From this study, it may be concluded that elevated homocysteine is associated with MetS. J Bangladesh Soc Physiol. 2020, June; 15(1): 1-5

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Section: Discussionmentioning

confidence: 99%

Homocysteine, vitamin B<sub>12</sub> and folic acid levels in metabolic syndrome

Nurjahan

Akter

Begum

2020

J Bangladesh Soc Physiol

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“…Deficiency of these vitamin may results in hyperhomocysteinemia. 13,14 In MS hyperhomocysteinemia can have synergistic effect to accelerate the development of cardiovascular complication. 15 Some researcher reported higher level of homocysteine and/or lower level of vitamin B 12 and folic acid, whereas some found no significant changes of this parameter in metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12, Folic acid and Homocysteine Levels in female metabolic syndrome patients and their relationship with Heart rate variability.

Akter¹,

Akter

Nurjahan

et al. 2021

J Bangladesh Soc Physiol

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Background: Metabolic syndrome (MeS) is a well-recognized risk factor for cardiovascular diseases. It is associated with hyperhomocysteinemia resulting from deficiency of vitamin B12 and folic acid. Both the MeS and hyperhomocysteinemia adversely affect heart rate variability. Objectives: To assess vitamin B12, folic acid and homocysteine levels in female metabolic syndrome patients and their relationship with heart rate variability. Methods: After taking ethical clearance from Institutional Review Board (IRB) of Bangabandhu Sheikh Mujib Medical University (BSMMU) this cross sectional study was conducted on 80 female subjects of 25-45 years of age. Among them 40 metabolic syndrome patients were included in the study group and 40 age matched apparently healthy female constituted control group. All the patients were enrolled from Outpatient Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh according to selection criteria. Serum vitamin B12, folic acid, homocysteine level was estimated by chemiluminescent immunoassay and frequency domain parameters of Heart Rate Variability (HRV) was recorded by a data acquisition device, Powerlab 8/35, AD instruments, Australia. Statistical aalysis was done by independent sample ‘t’ test and pearson correlation test. Results: In this study, among frequency domain HRV variables Total power(TP), low frequency power(LF), high frequency power (HF), HF normalized unit(nu) were significantly lower (p<0.05) and LF nu, LF/HF were significantly higher (p<0.05) in MS patients compared to those of control. In addition, no significant changes (p>0.05) were found in serum vitamin B12, folic acid and homocysteine levels between these two groups. But on correlation analysis only the folic acid level was significantly negatively correlated (p<0.05) with LF and HF power. Conclusion: The present study revealed that the folic acid level but not the vitamin B12 and homocysteine levels has significant negative correlation with heart rate variability in female MS. J Bngladesh Soc Physiol 2021;16(1): 24-32

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“…[5] Obesity induces elevation of blood glucose level [6] and reduction in serum vitamin B 12 level. [7][8] Both hyperglycemia and vitamin B 12 deficiency are risk factors for the development of peripheral neuropathy. [9][10] The role of obesity-independent of blood glucose level or serum vitamin B 12 level-on induction of peripheral neuropathy needs further investigation.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Dyslipidemia, Antioxidants and Nerve Conduction Velocity in Overweight and Obese Persons in Aswan

Elsaied

Sedeek

Fehr

et al. 2019

IJCEP

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Background and Aim: Overweight and obesity are major health problems leading to peripheral neuropathy. The exact mechanism of peripheral neuropathy in obesity is uncertain. However, increased oxidative stress and dyslipidemia are potential pathways. To find out the relationship between obesity and peripheral neuropathy in adults in Upper Egypt. Also, to clarify the role of dyslipidemia and oxidative stress in obesity-related neuropathy. Methods: Study groups are: normal weight, overweight and obese group (25 subjects in each group). All individuals underwent nerve conduction studies (NCS) of both median and ulnar nerves. In addition, lipid profile, TAC and MDA were measured in the serum. Result: We found significant increase in LDL, TG and MDA and significant reduction in HDL in obese compared to normal weight subjects. NCS showed significant slowing of NCV of right median motor and left median sensory, decrease in amplitude of ulnar motor nerves on both sides and right median motor nerve. Overweight group showed significant increase in LDL, TC and MDA compared to normal weight group. Conclusion: Our study suggested that obesity induces peripheral neuropathy. It also suggested that oxidative stress and dyslipidemia play an important role in the pathogenesis of obesity-related neuropathy.

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Assessment of Vitamin B12 Status in Patients with Morbid Obesity

Cited by 4 publications

References 10 publications

Homocysteine, vitamin B<sub>12</sub> and folic acid levels in metabolic syndrome

Homocysteine, vitamin B<sub>12</sub> and folic acid levels in metabolic syndrome

Vitamin B12, Folic acid and Homocysteine Levels in female metabolic syndrome patients and their relationship with Heart rate variability.

The Relationship between Dyslipidemia, Antioxidants and Nerve Conduction Velocity in Overweight and Obese Persons in Aswan

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