Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study

Noori, Akram; Lashkari, Mahin; Oveisi, Sonia; Khah, Mohamad Reza Khair; Zargar, Ali

doi:10.5539/gjhs.v6n6p82

Cited by 6 publications

(3 citation statements)

References 19 publications

(23 reference statements)

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“…sodium, phytate, high alcohol intake) are listed in Section 2.2.1 of the Opinion. This includes vitamin K; however, the evidence for an association between vitamin K and bone health is inconclusive (Macdonald et al, 2008;Stevenson et al, 2009;Nakano et al, 2011;Iwamoto et al, 2014;Noori et al, 2014;Torbergsen et al, 2015). It was considered that no change in the Scientific Opinion was needed in relation to this comment.…”

Section: Panel Consideration Of Comments Receivedmentioning

confidence: 99%

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2015

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to receive input from the scientific community and all interested parties on the draft Scientific Opinion on Dietary Reference Values (DRVs) for calcium, prepared by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) and endorsed by the Panel for public consultation at its Plenary meeting on 12 December 2014. The written public consultation for this document was open from 14 January 2015 to 28 February 2015. EFSA received comments from six interested parties. EFSA and its NDA Panel wish to thank all stakeholders for their contributions. The current report summarises the outcome of the public consultation, and includes a brief summary of the comments received and how the comments were addressed. The NDA Panel prepared an updated version of the Scientific Opinion on Dietary Reference Values for calcium taking into account the comments received. The Opinion was discussed and adopted at the NDA Plenary meeting on 23 April 2015, and is published in the EFSA Journal.

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Section: Panel Consideration Of Comments Receivedmentioning

confidence: 99%

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2015

EFSA Supporting Publications

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“…Recent findings suggest that vitamin K2 has antioxidant properties, which are based on a protective action against oxidative cellular damage, cell death by direct reactive oxygen species uptake, and limitation of free radical intracellular accumulation [6]. VK deficiency is rare in healthy people because it is widespread in food (VK1) and synthesized in the large intestine (VK2); although, it is still not clear if significant amounts of the produced VK2 are absorbed and utilized [7].…”

Section: Introduction 1backgroundmentioning

confidence: 99%

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Olszewska-Czyz,

Firkova

2023

Healthcare

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Background and Aim: Vitamin K2 (VK2) is an essential co-factor for bone metabolism. There is still very little data regarding possible VK2 relation to periodontitis. This study aimed to investigate any potential link between VK2 serum level and the severity of periodontitis in comparison to a control group of healthy individuals. The trial was performed on 100 patients among whom 50 were diagnosed with periodontitis. The patients underwent full clinical periodontal and radiological examination. The VK2 serum level was assessed using the ELISA kit (Gla-type osteocalcin EIA Kit, Takara, Kusatsu). Patients with periodontitis had mean serum levels of VK2 significantly lower (0.27 ± 0.06 nmol/L; p < 0.001) than the control group (0.43 ± 0.09 nmol/L; p < 0.001) regardless of the patient’s age or sex. The VK2 serum level decreased with the severity of periodontitis with the lowest level in stage IV of the disease (0.19 ± 0.01 nmol/L; p < 0.001). Also, a significant drop was noticed between the grades of periodontitis. Individuals with localized forms of the disease had significantly lower VK2 levels (0.26 ± 0.006 nmol/L; p < 0.001) in comparison to subjects with generalized periodontitis (0.30 ± 0.01 nmol/L; p < 0.001). The VK2 serum levels were also associated with most of the clinical parameters such as bleeding on probing (−0.805, 95% CI: −0.894 to −0.654, p < 0.001), attachment loss (−0.752, 95% CI: −0.862 to −0.574, p < 0.001), and bone loss (−0.656, 95% CI: −0.801 to −0.439, p < 0.001). In the present study, the VK2 serum level was correlated to periodontitis, and its severity, complexity, extension, and grade. The range of VK2 was decreasing together with the worsening of all clinical parameters of periodontitis.

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“…Currently research has been focused on links to age related diseases including; dementia and osteoporosis in humans (Noori et al 2014;Grimm et al 2016). As such there is an abundance of research in human and rodent studies, with limited research conducted in other species (Desjardin et al 2012).…”

Section: Is There a Relationship Between Osteocalcin And Equine Bone mentioning

confidence: 99%

Vitamin K and equine osteocalcin: an enigma explored

Skinner¹

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Vitamin K has received considerably less attention over the past 50 years compared to other fat soluble vitamins. Intakes of vitamin K beyond that required for normal blood coagulation were believed to confer no additional benefits, and therefore rarely investigated. The requirements and physiological role of vitamin K appeared to be secure. This view of vitamin K has changed recently following the delineation of its cofactor role in protein carboxylation, and the growing awareness of its interactions with other essential metabolic functions, beyond that of blood coagulation; there is much to be discovered. At present, seventeen vitamin Kdependent proteins (VKDPs) have been characterised, but the functionality of some still remains to be elucidated. Vitamin K has recently been implicated in osteoarthritis and accumulating evidence from human studies supports a protective role for vitamin K. To date however, little research into the role vitamin K may play in equine bone development exists. Developmental orthopaedic disease (DOD) is a term that encompasses a number of bone related conditions in the horse. It is a significant cause of lameness and wastage in a number of breeds, in particular Thoroughbreds and Warmbloods. It has clinical features in common with that of osteoporosis and osteoarthritis in the elderly. The VKDP osteocalcin is one of the few that has been extensively studied in humans and rodents. Located within bone, this protein plays a vital role in bone metabolism, facilitating the binding of bone minerals with protein. Decreased functionality of this protein has been found to be associated with increased fracture risk and osteoporosis in humans. The studies in this program were initiated to establish the relationship between vitamin K status and the development of DOD in foals. As bone development begins in utero, the first step was to examine placental transfer of the vitamin and then determine availability to the foal through milk. It was found in the initial experiments (Chapter 3), that foals at birth, had negligible concentrations of vitamin K1 (<0.01ng/mL) in both umbilical cord and foal plasma. The results clearly demonstrated that there is limited trans-placental transfer of vitamin K in the horse. It was also shown that milk can be enriched with vitamin K by supplementation of the mare with the vitamin. These studies confirmed that plasma concentrations were not a reliable measure of overall vitamin K status. Circulating osteocalcin and, its carboxylation status, has been proposed as one of the indicators of vitamin K status and a 'biomarker' of bone metabolism. Current assays available to measure Publications included in this thesis "No publications included". v

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Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study

Cited by 6 publications

References 19 publications

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A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Vitamin K and equine osteocalcin: an enigma explored

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