Assessment risk of osteoporosis in Chinese people: relationship among body mass index, serum lipid profiles, blood glucose, and bone mineral density

Abstract

ObjectiveThe aim of our study was to investigate the relationship among age, sex, body mass index (BMI), serum lipid profiles, blood glucose (BG), and bone mineral density (BMD), making an assessment of the risk of osteoporosis.Materials and methodsA total of 1,035 male and 3,953 female healthy volunteers (aged 41–95 years) were recruited by an open invitation. The basic information, including age, sex, height, weight, waistline, hipline, menstrual cycle, and medical history, were collected by a questionnaire survey and physical examination. Serum lipid profiles, BG, postprandial blood glucose, and glycosylated hemoglobin were obtained after 12 hours fasting. BMD in lumbar spine was measured by dual-energy X-ray absorptiometry scanning.ResultsThe age-adjusted BMD in females was significantly lower than in males. With aging, greater differences of BMD distribution exist in elderly females than in males (P<0.001), and the fastigium of bone mass loss was in the age range from 51 to 55 in females and from 61 to 65 years in males. After adjustment for sex, there were significant differences in BMD among BMI-stratified groups in both males and females. The subjects with a BMI of <18.5 had a higher incidence of osteoporosis than BMI ≥18.5 in both sexes. BMD in type 2 diabetes mellitus with a BG of >7.0 mmol/L was lower than in people with BG of ≤7.0 mmol/L (P<0.001). People with serum high-density lipoprotein cholesterol levels of ≥1.56 mmol/L had a greater prevalence of osteoporosis compared with high-density lipoprotein cholesterol ≤1.55 mmol/L. Logistic regression with odds ratios showed that no association was found among total cholesterol, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin, postprandial blood glucose and BMD.ConclusionThe present study further confirmed that factors such as age, sex, weight, BMI, high-density lipoprotein cholesterol, and diabetes are significant predictors of osteoporosis in the Chinese people.

Influence of Apelin-13 on osteoporosis in Type-2 diabetes mellitus: A clinical study

“…The difference in BMD distribution between genders may be explained by the differences in endocrine and paracrine factors, and the rapid decrease of sex steroid levels in postmenopausal women aggravates the bone loss. 17 In addition, we found that the level of Apelin-13 was negatively related to age, demonstrating the risk of osteoporosis may be added with age, this conclusion was consistent with previous studies. 17 …”

“… 17 In addition, we found that the level of Apelin-13 was negatively related to age, demonstrating the risk of osteoporosis may be added with age, this conclusion was consistent with previous studies. 17 …”

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

“…Aging is one of the most important factors affecting bone mineral density (BMD), with certain underlying influential factors 1–3. However, many studies have been mainly focused on women concerning postmenopausal osteoporosis.…”

Total Knee Arthroplasty in Patients with Rheumatoid Arthritis, Severe Osteoporosis, and Genu Valgum

“…This was a retrospective study of patients with RA, osteoporosis, and genu valgus treated using TKA at the Orthopedics Department of the Fourth A liated Hospital of Harbin Medical University between May 2016 and May 2019. This work has been carried out in accordance with the Declaration of Helsinki The inclusion criteria were: 1) preoperative femorotibial angle of 18°-27°; 2) rst-ever TKA; 3) TKA through the medial parapatellar approach; 4) severe osteoporosis, de ned as mean bone mineral density (BMD) Tvalue measured by dual-energy X-ray of -3.7 ± 0.6 [11]; and 5) follow-up of at least 1 year. The exclusion criteria were: 1) femorotibial angle > 27°; 2) received revision surgery; 3) TKA through the lateral parapatellar approach; 4) dual-energy X-ray absorptiometry (DEXA) showed that the T value of BMD >-3; and 5) poor compliance to follow-up.…”

“…DEXA (Lunar DPX-NT; GE, Boston, Massachusetts, USA) was used to measure the bone mineral density (BMD) of the lumbar vertebral body, bilateral femoral necks, Ward's trigonum, and greater trochanter of all the patients on the anteroposterior images. All patients had to meet the diagnostic criteria of osteoporosis, as in the Suggested Diagnostic Criteria of Osteoporosis in Chinese People (2nd edition) issued in 2000 [11].…”