Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire

Bahi, Gnogbo Alexis; Boyvin, Lydie; Souleymane, Méité; M’boh, Gervais Melaine; Yeo, K. H. J.; N’guessan, K.; Bidie, Alain Dit Philippe; Djaman, Allico Joseph

doi:10.1186/s12879-017-2343-7

Cited by 30 publications

(18 citation statements)

References 15 publications

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“…The highest Cu/Zn ratio of 2.00 was in the 6-year-old girl with hypercupremia (158 µg/dL) and normal serum zinc (80 µg/dL). A pattern of high copper and low zinc is characteristic of an inflammatory condition [50], and a Cu/Zn ratio greater than 2 means there is a severe bacterial infection [73]. This situation might indicate that an inflammatory status was prevalent in most CF patients in this series.…”

Section: Copper/zinc Ratiomentioning

confidence: 80%

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Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

et al. 2020

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Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76.5% of whom were ∆F580. Their mean serum copper (113 ± 23 μg/dL) was normal, and there was only one teenager with hypocupremia (6%) and two children with hypercupremia (18%). A significant association between serum copper and zinc levels was discovered. The Cu/Zn ratio was higher than 1.00 for 94% of patients, which is an indicator of an inflammation status. There was no significant correlation between the serum copper concentrations and respiratory and pancreatic function, respiratory colonization, and the results of the abdominal ultrasound. Linear regression analysis showed that serum copper had a positive association with both the Z-score body mass index (BMI) and mean bone conduction speed (BCS). Therefore, since 94% of CF patients had a Cu/Zn ratio > 1.00, this factor must alert us to consider the risk of zinc deficiency and high inflammatory response. The measurement of serum zinc alone does not show one’s zinc status. However, the Cu/Zn ratio may be an indicator of zinc deficiency and the inflammatory status of CF patients.

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Section: Copper/zinc Ratiomentioning

confidence: 80%

“…The Cu/Zn ratio has also been related to childhood neurological disorders [72] and assaultive individuals [76]. Additionally, the Cu/Zn ratio is an indicator of the nutritional status of zinc in patients [73]. Zinc deficiency should be highly suspected in individuals with high serum Cu/Zn ratios.…”

Section: Copper/zinc Ratiomentioning

confidence: 99%

Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

et al. 2020

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“…During in vitro infections with M.tb, the expression patterns of various ZIPs were observed to change; for example, the expression levels of ZIP10 and ZIP8 decrease and increase, respectively, indicating that M.tb alters zinc homeostasis [57]. Patients with active TB and MDR-TB have low levels of zinc at diagnosis moment, but the zinc level increases after anti-TB treatment [58,59]. This alteration in zinc homeostasis is partly explained as a host strategy against the pathogen; however, the mechanism by which zinc functions in M.tb control has not been fully elucidated.…”

Section: Zincmentioning

confidence: 99%

Malnutrition and tuberculosis: the gap between basic research and clinical trials

Téllez-Navarrete

Ramón‐Luing

Muñoz-Torrico

et al. 2021

J Infect Dev Ctries

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Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis (TB), an infectious disease that leads to numerous deaths worldwide. Malnutrition, smoking, alcohol abuse, Human Immunodeficiency Virus infection, and diabetes are some of the most important risk factors associated with TB development. At present, it is necessary to conduct studies on risk factors to establish new effective strategies and combat this disease. Malnutrition has been established as a risk factor since several years ago; although there is in vitro experimental evidence that reveals the importance of micronutrients in activating the immune response against M.tb, evidence from clinical trials is controversial. Currently, nutritional assessment is recommended in all TB patients upon diagnosis. However, there is insufficient evidence to indicate micronutrient supplementation as adjuvant therapy or prophylactic to prevent micronutrient depletion. Strengthening the interaction between basic and clinical research is necessary to carry out studies that will help establish adjuvant therapies to improve outcomes in TB patients. In this review, we discuss the experimental evidence, provided by basic research, regarding micronutrients in the TB field. However, when these studies are applied to clinical trials, the data are inconsistent, indicating that still missing mechanisms are necessary to propose alternatives to the treatment of TB patients.

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“…Terjadinya mutasi gen karena gangguan sistesis DNA dan RNA yang diakibatkan oleh stres oksidatif menyebabkan kuman TB menjadi resisten. 27 Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan kadar seng dan MDA pada penderita MDR-TB dan TB sensitif.…”

Section: Pendahuluanunclassified

“…Meningkatnya kadar seng serum dimungkinkan karena terapi obat tuberkulosis menyebabkan penurunan jumlah kuman dan menyebabkan penurunan aktivitas antioksidan endogen yaitu supeoxide dismutase (SOD) dimana bahan penyusun utamanya adalah seng, dalam mendetoksifikasi reactive oxygen species (ROS). 27,28 Peningkatan kadar seng pada akhir pengobatan kemungkinan merupakan penanda untuk memantau tingkat keparahan penyakit dan respon terhadap terapi. 30 Tabel 3 juga menunjukkan bahwa tidak terdapat perbedaan yang signifikan kadar MDA pada kelompok MDR-TB dan kelompok TB sensitif (p=0,147 33 Rerata kadar MDA pada kelompok TB sensitif lebih tinggi dibandingkan kelompok MDR-TB.…”

Section: Pembahasanunclassified

Kadar seng dan kadar malondialdehyde pada penderita multi drug resistant tuberculosis dan tuberkulosis sensitif

Suparno

Suhartono

Sofro

et al. 2018

JGI

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Background: Zinc is the main constituent element of Superoxide Dismutase (SOD) which acts to protect cells from inflammation and the toxic effects of Reactive Oxygen Species (ROS). High ROS production induces fat peroxidation, and forms malondialdehyde (MDA) which causes oxidative stress.Objectives: This study aimed to analyze the difference of zinc and malondialdehyde levels among Multi Drug Resistant Tuberculosis and sensitive Tuberculosis.Methods: Crossectional study with 55 subjects consisted of 32 MDR-TB subjects and 23 subjects TB sensitive. Selection of subjects using consecutive sampling. Zinc and MDA serum was obtained from venous blood. Zinc and MDA concentration were assessed by quantitative colometric and Thiobarbituric Acid Reactive Substances (TBARS) respectively. Data were analized statistic by independent t-test and Mann Whitney test.Results: Zinc level of MDR-TB and TB sensitive were 74.85 (64 - 97) μg/dl and 73.03 (63 - 97) μg/dl respectively, while MDA of MDR-TB and sensitive TB were 2.262±1.055 nmol/mL and 2.66±0.992 nmol/mL. There was no significantly different in zinc level between MDR-TB and sensitive TB (p=1.000). Furthermore, there was not significantly different of MDA level between MDR-TB and sensitive Tuberculosis (p=0,147).Conclusion: There are no differences in zinc and MDA levels in patient between MDR-TB and sensitive TB.

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Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire

Cited by 30 publications

References 15 publications

Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

Malnutrition and tuberculosis: the gap between basic research and clinical trials

Kadar seng dan kadar malondialdehyde pada penderita multi drug resistant tuberculosis dan tuberkulosis sensitif

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