Assessments of Two Rat Models of Fulminant Hepatic Failure for Testing Artificial Liver Devices

Chirito, E.; Reiter, B; Lister, C.; Chang, Thomas Ming Swi

doi:10.1007/978-1-4684-2478-2_26

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…We therefore carried out detailed control studies in galactosamineinduced hepatic failure rats to allow for a more valid statistical analysis Chang, 1971aChang, , 1978bChirito et al, 1978Chirito et al, , 1979Mohsini et al, 1980;Tabata and Chang, 1980). With this model we can avoid variations in age, etiology and grades of coma.…”

Section: Control Studies In Galactosamine-induced Hepatic Failure Ratsmentioning

confidence: 99%

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

Chang¹

2017

Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Biospecific, Immuno and Leucocyte Adsorbents

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Section: Control Studies In Galactosamine-induced Hepatic Failure Ratsmentioning

confidence: 99%

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

Chang¹

2017

Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Biospecific, Immuno and Leucocyte Adsorbents

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Hemoperfusion and DNA Synthesis in the Rat Liver Part I: The Effect of Hemoperfusion on the Rate of DNA Synthesis

et al. 1982

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An investigation has been made into whether charcoal hemoperfusion stimulates a hyperplastic response in the liver of the normal rat. Animals underwent hemoperfusion over Norit RBX1 (Strathclyde, Glasgow, U.K.) charcoal granules using a technique which allowed perfusion in the unrestrained and conscious state. Controls consisted of animals subjected to perfusion through empty columns and animals cannulated only. Body weight, liver weight, function, and DNA synthesis were recorded at various times after completion of perfusion and control procedures. The results indicated that charcoal hemoperfusion did not stimulate a hyperplastic response in the liver of the normal rat following perfusion, and did not produce marked changes in body weight, liver weight, and function.

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The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat

1982

Int J Artif Organs

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An investigation has been made of the suitability of a rat hemoperfusion system for the evaluation of hematological changes induced by charcoal hemoperfusion. The investigation studied the influence on erythrocyte, leucocyte and thrombocyte levels of repeated hemoperfusion over Norit RBX1 charcoal, hemoperfusion over polymer-coated Norit RBX1 and hemoperfusion over uncoated spherical charcoal. Controls included animals subjected to hemoperfusion through empty columns and animals cannulated only. The results indicate that changes in erythrocyte and leucocyte levels are due principally to passage of blood through the extracorporeal circuit rather than contact with the adsorbent but that changes in thrombocyte levels are dependent on the type of charcoal and the nature and extent of polymer coating. The investigation suggests that the rat hemoperfusion system is a suitable procedure for the assessment of the compatibility of adsorbents to be used in hemoperfusion.

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Assessments of Two Rat Models of Fulminant Hepatic Failure for Testing Artificial Liver Devices

Cited by 3 publications

References 3 publications

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

Hemoperfusion and DNA Synthesis in the Rat Liver Part I: The Effect of Hemoperfusion on the Rate of DNA Synthesis

The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat

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