The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat

Repeated membrane plasma separation with on-line sorbent treatment of plasma was performed in unrestrained and conscious rats, thus avoiding the possible effects of repeated stress and exposure to anesthetic agents. The procedure was well tolerated, even after four consecutive perfusions. Blood flow was 0.7 ml/min, with a transmembrane pressure of 18.6 mm Hg and plasma filtration rate of 0.21 ml/min. This allowed 12 ml of plasma (greater than 1 plasma volume) to be treated within 1 h. Levels of albumin, immunoglobulin G, and C3 remained constant during each perfusion and were not significantly different from those of animals subjected to control procedures. Results obtained from filtrate were comparable at 15 and 60 min with values obtained from whole blood, with sieving coefficients of approximately 1. Leukocyte, erythrocyte, and thrombocyte counts remained unchanged during each plasma perfusion. A progressive rise in leukocyte counts occurred following successive perfusions, but this was true also of animals subjected to control procedures.

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Experiments with Continuous Hemofiltration and Hemofiltrate Regeneration in the Rat

Bøttcher

Falkenhagen

Nebe

et al. 1986

Int J Artif Organs

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Experimental studies were made with continuous hemofiltration treatment for bilaterally nephrectomized rats and initial observations regarding the effects of such treatment on leukocyte and thrombocyte counts are reported. Hemofiltration of unanesthetized rats able to move freely within their cage could be continued for up to 30 h using a pump-driven ECC system. Blood parameters recorded during this treatment indicate that the detoxification was effective. In another series of experiments the water and electrolyte reabsorption capacity of the colon ascendens of healthy rats was tested by continuously supplying NaCl solution into the colon via a fistula. A large proportion, if not all, of the hemofiltrate can be discharged into the colon without diarrhoea. A final series of experiments showed that the three-stage operation (implantation of permanent catheters, connection of a permanent intestinal fistula and bilateral nephrectomy) is possible with the rat.

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The Effect of Hemoperfusion over Uncoated and Polymer — Coated Charcoal on Hematological Levels in the Conscious Rat

Cited by 4 publications

References 16 publications

Pre-Dna Synthesis Haemoperfusion

Pre-Dna Synthesis Haemoperfusion

Repeated Membrane Plasma Separation with On‐Line Sorbent Treatment of Plasma in the Conscious Rat

Experiments with Continuous Hemofiltration and Hemofiltrate Regeneration in the Rat

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