Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI))

Carney, Sarah-Kate; Sangeeta, Das; Blake, Debbie; Farquhar, Cindy; Seif, Mourad Mw; Nelson, Louisa

doi:10.1002/14651858.cd001894.pub5

Cited by 62 publications

(86 citation statements)

References 84 publications

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“…While there have been multiple reports comparing ART outcomes in cycles with and without AH, most have defined poor prognosis as prior failed cycles or based on maternal age rather than looking specifically at FSH concentration. Many such studies support a role for AH in improving clinical pregnancy rates in women who are at least 38 years old or who have had unsuccessful prior ART cycles; several studies have also demonstrated improvements in ongoing/live birth rates in these subpopulations (19–22, 36). In contrast, Assemi et al published a study more analogous to ours in its comparison of 154 initial ART cycles all with FSH >=10 IU/L according to whether AH was performed.…”

Section: Discussionmentioning

confidence: 88%

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

Butts

Owen

Mainigi

et al. 2014

Fertility and Sterility

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Objective To investigate the impact of intracytoplasmic sperm injection (ICSI) and assisted hatching (AH) on ART outcomes in cycles with diminished ovarian reserve (DOR) as the primary diagnosis. Design Retrospective cohort study of cycles from the SART-CORS database. Setting NA. Patient(s) A total of 422,949 fresh, non-donor, initial ART cycles of which 8,597 were diagnosed with only elevated FSH and 38,926 were diagnosed with only DOR according to the SART DOR categorization. Intervention(s) None. Main Outcome Measure(s) Live birth and clinical pregnancy rates. Result(s) ICSI and AH were associated with diminished odds of live birth in SART DOR only cycles (AOR, 95% CI 0.88, 0.81–0.96 for ICSI; AOR, 95% CI 0.77 0.71–0.84 for AH). No association between either ICSI or AH in Elevated FSH only cycles was observed. The combination of ICSI and AH resulted in significantly lower odds of live birth in SART DOR only cycles but not in Elevated FSH only cycles. Conclusion(s) In initial ART cycles for which the only indication relates to a diagnosis of diminished ovarian reserve, assisted hatching and ICSI are not associated with improved live birth rates.

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Section: Discussionmentioning

confidence: 88%

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

Butts

Owen

Mainigi

et al. 2014

Fertility and Sterility

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“…We conducted this study due to the paucity of data indicating the role of AH on the outcome in cases without known poor prognosis with their first fresh cycles (21).…”

Section: Discussionmentioning

confidence: 99%

“…Another study showed higher implantation rate in group with blastocyst stage embryo transfer and partial assisted hatching in this group resulted in favorable outcome (20). However, there is still no clear evidence indicating the role of AH on the outcome of cases without known poor prognosis with their first fresh cycles (21).…”

Section: Introductionmentioning

confidence: 92%

Effect of Total versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology

Bilgiç

Özkaya

Abide

et al. 2019

Gynecol Obstet Reprod Med

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OBJECTIVE:The objective of this study was to investigate the effect of total or partial assisted hatching on the clinical pregnancy rates in assisted reproduction technology. STUDY DESIGN:This was a case-control study conducted from the beginning of January 2016 to the end of June 2017. A total of 404 cycles were included in this case-control study. Study population was divided into 3 groups: Group 1: Partial assisted hatching (n=118), Group 2: Total assisted hatching (n=81) and Control group (n=205). RESULTS:In women of all ages, clinical pregnancy rates were similar between groups with total or partial assisted hatching compared to control group (p>0.05). The rates were also similar in subgroups of women with blastocyst or cleavage stage embryo transfers (p>0.05). Partial or total embryo hatching did not result in favorable outcome compared to control group either in women over 35 or younger than 35 years of age (p>0.05). In whole study group pregnancy rate was significantly higher in group with blastocyst stage embryo transfers (22.4 % versus 48.8%, p<0.05) CONCLUSION: Partial or total assisted hatching do not have any impact on the clinical pregnancy rates, no significant impact was determined in subgroup of women either.

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“…Yet, the effectiveness of AH to improve the outcome of fresh and frozen IVF/ICSI-ET cycles remains controversial (Ng et al, 2005;Ge et al, 2008;Lan et al, 2009;Carney et al, 2012;Razi et al, 2013;Wan et al, 2014).…”

Section: Assisted Hatching In Frozen Cyclesmentioning

confidence: 99%

The impact of laser-assisted hatching on the outcome of frozen human embryo transfer cycles

Kanyó

Zeke

Kriston

et al. 2016

Zygote

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SummaryBiochemical modifications of zona pellucida (ZP) result in zona hardening. Zona hardening (ZH) is induced by several factors such as advancing maternal age, in vitro culture conditions and cryopreservation and adversely effects implantation. The objective of the clinical study was to determine whether or not laser-assisted hatching (LAH) applied on day 3 frozen embryos improves the outcome of frozen embryo transfer (FET) cycles in patients with recurrent implantation failure and/or advanced female age. In total, 413 patients of different ages with recurrent implantation failure (maximum three cycles) were involved into the study. Patients were allocated randomly into LAH and control groups. On the day of FET, after thawing and just before FET, the ZP was thinned using a laser system. In the control group no treatment was applied on frozen embryo before transfer. The main outcome measures were clinical pregnancy rate. Overall, the results indicate a tendency that LAH increased (P = 0.08) clinical pregnancy. However, for patients older than 37 years, LAH increased pregnancy rates significantly (P = 0.03). In the LAH and control groups, the age of patients and the number of transferred embryos influenced pregnancy rates (P = 0.01). For patients older than 37 years, no effect of number of transferred embryos was detected (P = 0.14). The incidence of multiple pregnancies also increased in the LAH group (P = 0.01). In conclusion, in older woman, to overcome the negative effect of zona hardening, LAH could be performed on frozen embryos as a routine strategy before FET in frozen cycles in order to increase the possibility of pregnancy formation.

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Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI))

Abstract: Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)).

Cited by 62 publications

References 84 publications

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

Effect of Total versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology

The impact of laser-assisted hatching on the outcome of frozen human embryo transfer cycles

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