Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE

Mouzon, J. de; Goossens, V.; Bhattacharya, Siladitya; Castilla, José Antonio; Ferraretti, Anna Pia; Корсак, В. С.; Kupka, M.; Kg, Nygren; Andersen, A. Nyboe

doi:10.1093/humrep/deq124

Cited by 364 publications

(180 citation statements)

References 17 publications

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“…[Centers for Disease Control and Prevention ASRM, Society for Assisted Reproductive Technology 2007; de Mouzon et al 2010]. Although inferior pregnancy rates were previously observed in FET cycles compared to fresh IVF embryo transfer (IVF-ET) cycles, continued refinements in vitrification methods have resulted in similar pregnancy success in FET cycles and fresh IVF-ET cycles [Roque et al 2013;Roque et al 2015;Shapiro et al 2011;Wada et al 1994].…”

Section: Introductionmentioning

confidence: 99%

A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation

Guan

Fan

Styer

et al. 2016

Systems Biology in Reproductive Medicine

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(2016) A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation, Systems Biology in Reproductive Medicine, 62:5, 335-342, DOI: 10.1080/19396368.2016 To link to this article: https://doi.org/10. 1080/19396368.2016 There is no consensus regimen for the optimal endometrial preparation for cryopreservation and vitrified-thawed embryo transfer cycles. This is largely caused by the lack of sufficient investigation and analyses on the respective pregnancy and perinatal outcomes by different regimens. This study aimed to compare both pregnancy and perinatal outcomes between the modified natural and artificial cycles in vitrified-thawed day three embryo transfer for women with regular menstruation. A total of 1,482 vitrified-thawed day three embryo transfer cycles were reviewed including 427 modified natural cycles (NC), 132 ovulation induction cycles (OC), 794 artificial cycles (AC), and 129 GnRH agonist artificial cycles (GAC). The primary outcome that was evaluated was live birth rate. The NC regimen demonstrated a higher rate of ongoing pregnancy (43.8% vs. 30.2%, P = 0.002) and a lower rate of late abortion (2.8% vs. 14.0%, P = 0.003) than the GAC regimen as well as a higher implantation rate (31.9% vs. 27.1%, P = 0.008) and live birth rate (43.1% vs. 34.1%, P = 0.002) than the AC regimen. A significantly higher peak endometrial thickness before transfer was observed in patients using the NC and GAC regimens (10.0 ± 1.7, 9.9 ± 2.4) compared to the AC regimens (9.2 ± 1.5, P = 0.000). Multivariate logistic regression showed that the NC protocol was associated with a higher live birth rate. There were no significant differences in rates of pregnancy complications, neonatal mortality, birth defects, mean birth weight, and other perinatal outcomes among the regimens. Modified natural cycle endometrial preparation regimen for vitrified-thawed day three embryo transfer is associated with superior live birth pregnancy outcomes compared to artificial cycles. Future studies are warranted to investigate the underlying biologic mechanisms of these findings.Abbreviations ART: assisted reproductive technology; BMI: body mass index; FET: frozen-thawed embryo transfer; HCG: human chorionic gonadotropin; IVF: in-vitro fertilization; IVF-ET: in-vitro fertilization and embryo transfer; OHSS: ovarian hyperstimulation syndrome; RCTs: randomized controlled trials ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation

Guan

Fan

Styer

et al. 2016

Systems Biology in Reproductive Medicine

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“…Since that time, the proportion of assisted reproductive technology procedures involving embryo cryopreservation has risen [2]. The pregnancy rates for these procedures have also improved, drastically increasing the number of FETs performed yearly.…”

Section: Introductionmentioning

confidence: 99%

Developmentally delayed cleavage-stage embryos maintain comparable implantation rates in frozen embryo transfers

Burks

Buckbinder

Francis-Hernandez

et al. 2015

J Assist Reprod Genet

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Purpose In fresh IVF cycles, embryos reaching the eight-cell stage on day 3 of development are thought to have a higher chance of implantation than those reaching this stage on day 4. To determine whether this difference persists after cryopreservation, we compared pregnancy and implantation rates between frozen embryo transfer (FET) cycles using delayed cleavage-stage embryos (cryopreserved day 4) and normal cleavage-stage embryos (cryopreserved day 3). Methods Participants underwent FET between 2008 and 2012 using embryos cryopreserved on either day 3 (n=76) or day 4 (n=48), depending on the length of time needed to achieve the eight-cell stage. All embryos, regardless of day of cryopreservation, were thawed and transferred on the 4th day of vaginal progesterone following endometrial preparation with oral estradiol. Chi-square and Mann-Whitney U tests were used to compare patient demographics and cycle outcomes. Results More women in the day 4 group had diminished ovarian reserve (44 vs 16 %, p=0.003). Pregnancy outcomes in preceding fresh cycles were not different between the two groups. Pregnancy, implantation, and live birth rates following FET did not differ between the day 3 and day 4 groups. Conclusions This is the first study to address outcomes using day 3 versus day 4 cryopreserved embryos. Despite a higher prevalence of diminished ovarian reserve (DOR) in the day 4 group, delayed cleavage-stage embryos utilized in FET cycles performed as well as embryos growing at the normal rate, suggesting delayed embryo development does not affect embryo implantation as long as endometrial synchrony is maintained.

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“…In vitro fertilization and embryos transfer (IVF-ET) has become increasingly popular and the pregnancy rate was improved by the development of the technology [1,2]. Many women in advanced age want to have babies through IVF.…”

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confidence: 99%

Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET)

Yan

Tang

et al. 2012

Sci. China Life Sci.

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This is a retrospective, observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET). 11830 IVF-ET cycles from 10268 women were included. Four groups of different maternal age periods were compared. The groups were 2130 years old group (4549 cycles), 31-35 years old group (4424 cycles), 36-40 years old group (2429 cycles), and over 40 years old group (428 cycles). The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher (P<0.01), while the mean retrieved oocyte number was significantly lower (P<0.01) in groups of higher maternal age period than those in each of the lower groups. The biochemical pregnancy rate and the clinical pregnancy rate were significantly lower (P<0.01), while the miscarriage rate was significantly higher (P<0.01) in groups of higher maternal age period than those in the lower groups. No difference was found in two-pronuclear zygotes (2PN) rate and good quality embryo rate among different groups. Birth defect rate was also comparable in the born babies in different groups. In the group with patients' age over 40 years old, the pregnancy rate was 26.87%, the clinical pregnancy rate was 19.39%, while the miscarriage rate after clinical pregnancy was 36.14%. To draw the conclusion, patients with higher maternal age had worse IVF outcomes. In women of fertile age, patients between 20 and 30 years old have the best IVF outcomes. Patients over 40 years old have poor IVF outcome and high miscarriage rate, which suggested the necessity of preimplantation genetic screening (PGS).in vitro fertilization, outcome, pregnancy rate, miscarriage rate, birth defect, maternal age Citation:Yan J H, Wu K L, Tang R, et al. Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET). Sci China Life Sci, 2012, 55: 694 -698,

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Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE

Abstract: Compared with previous years, the reported number of ART cycles in Europe has increased, pregnancy rates have increased marginally, even though fewer embryos were transferred and the multiple delivery rates have declined.

Cited by 364 publications

References 17 publications

A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation

A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation

Developmentally delayed cleavage-stage embryos maintain comparable implantation rates in frozen embryo transfers

Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET)

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