Associação entre perfil glicêmico materno e o índice de líquido amniótico em gestações complicadas pelo Diabetes mellituspré-gestacional

Maganha, Carlos Alberto; Nomura, Roseli Mieko Yamamoto; Zugaib, Marcelo

doi:10.1590/s0104-42302009000200021

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Maternal metabolic control has been directly associated with complications and deaths in pregnant women with DM (2). Diabetes during pregnancy can lead to or aggravate placental abnormalities, which will impact the systemic balance between the pregnant woman and her fetus.…”

Section: Introductionmentioning

confidence: 99%

Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus

Salge¹,

Rocha²,

Xavier³

et al. 2012

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OBJECTIVES:The current study sought to identify macroscopic placental changes associated with clinical conditions in women with or without diabetes and their newborns.METHODS:The study population consisted of 62 pregnant women clinically diagnosed with diabetes and 62 healthy women (control group).RESULTS:Among the subjects with diabetes, 43 women (69.3%) were diagnosed with gestational diabetes mellitus, 15 had diabetes mellitus I (24.2%), and four had diabetes mellitus II (6.5%). The mean age of the women studied was 28.5±5.71 years, and the mean gestational age of the diabetic women was 38.51 weeks. Of the 62 placentas from diabetic pregnancies, 49 (79%) maternal surfaces and 59 (95.2%) fetal surfaces showed abnormalities, including calcium and fibrin deposits, placental infarction, hematoma, and fibrosis. A statistical association was found between newborn gender and fetal and maternal placental changes (p = 0.002). The mean weight of the newborns studied was 3,287±563 g for women with diabetes mellitus, 3,205±544 g for those with gestational diabetes mellitus, 3,563±696 g for those with diabetes mellitus II, and 3,095±451 g for those with diabetes mellitus I.CONCLUSIONS:Infarction, hematoma, calcification, and fibrin were found on the maternal and fetal placental surfaces in women with diabetes. Women with gestational diabetes and post-term infants had more calcium deposits on the maternal placental surface as compared to those with type I and type II diabetes.

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Section: Introductionmentioning

confidence: 99%

Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus

Salge¹,

Rocha²,

Xavier³

et al. 2012

Clinics

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“…A hiperglicemia materna levando à fetal pode promover aumento no vLA em diferentes semanas gestacionais, favorecendo o crescimento excessivo fetal 106 . No entanto, resultados controversos são constatados no seguimento de gestantes com diabetes pré-gestacional 107 . Após períodos de hiperglicemia materna e fetal, mesmo quando se obtém controle metabólico materno, nem sempre ocorre o retorno do vLA aos níveis normais.…”

Section: Diabetesunclassified

Avaliação da vitalidade fetal anteparto

Nomura¹,

Miyadahira²,

Zugaib³

2009

Rev. Bras. Ginecol. Obstet.

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RevisãoResumo O contexto atual da atividade médica exige do obstetra e ginecologista ampla compreensão dos avanços científicos e tecnológicos de sua área. O objetivo primordial da avaliação fetal antenatal é identificar fetos de risco para eventos adversos ou para o óbito e, assim, atuar preventivamente para evitar o insucesso. O perfil biofísico fetal atinge sua máxima eficiência quando aplicado dentro do contexto clínico de cada caso. Em gestações de alto risco, a doplervelocimetria da artéria umbilical mostrou-se útil para melhorar os resultados perinatais. Na restrição de crescimento fetal por insuficiência placentária grave, antes da 34ª semana de gestação, a doplervelocimetria do ducto venoso tem sido importante instrumento na condução dos casos. Nenhum teste isoladamente é considerado o melhor na avaliação da vitalidade fetal anteparto, entretanto, a análise conjunta de todos os métodos irá propiciar melhor compreensão da resposta fetal à hipóxia. AbstractThe present context of medical practice demands from the obstetrician and gynecologist broad understanding of the scientific and technological advances of the area. The main purpose of prenatal evaluation is to identify fetuses at risk for adverse events or death, for preventive action to avoid mishappenings. The determination of fetal biophysical profile reaches its maximum efficiency when applied within the clinical context of each case. In high risk gestations, the Doppler velocimetry of the umbilical artery has shown to be useful to improve perinatal outcome. In the fetal growth deficit, due to severe placentary insufficiency, Doppler velocimetry of the venous duct has been showing to be an important tool in handling of the cases before the 34 th week of gestation. Although no test itself is considered the best to evaluate the fetus's prenatal vitality, the joint analysis of all methods may lead to a better understanding of the fetal response to hypoxia.

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“…One of these pregnancy pathologies is gestational diabetes mellitus (GDM) (1) . DM is a common clinical condition that affects approximately 1 to 15% of pregnant women (2) . GDM is a metabolic disease defined as progressively impaired glucose intolerance with the onset or first recognition during pregnancy (3) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Morphological (Macroscopic and Microscopic) Parameters of Placentas in Pregnancies Complicated by Preeclampsia, Diabetes and Preeclampsia and Diabetes

2021

IJFMT

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This study was done to compare the morphometric parameters of placentas in well controlled patients with preeclampsia, diabetes, and preeclampsia-diabetes with that of normal uncomplicated placentas.Patients &Methods: A total of Twenty four placentas were freshly collected. Six placentas for control group and eighteen placentas for complicated group (preeclamptic-diabetic and preeclamptic--diabetic subgroups). The placentas were grossly examined (shape, number of cotyledons, weight, and thickness). After suitable fixation, tissue processing and sectioning, the sections were stained by hematoxylin and eosin to study the general morphology and morphometry of the following parameters: number of terminal villi, number of syncytial knots, number of apoptotic cells and number of fetal capillaries. Result:The weight of the baby in D-subgroup was significantly increased when compared with control group and with P and P-D subgroups . Microscopical morphometry regarding number of terminal villi, apoptotic cells, syncytial knots and fetal capillaries were increased in complicated subgroups. The thickness of basement membrane was 0.8µm in control group and it was increased in all complicated subgroups. The highest value was reported by D-subgroup (2 µm).

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Associação entre perfil glicêmico materno e o índice de líquido amniótico em gestações complicadas pelo Diabetes mellituspré-gestacional

Cited by 3 publications

References 24 publications

Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus

Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus

Avaliação da vitalidade fetal anteparto

Evaluation of Morphological (Macroscopic and Microscopic) Parameters of Placentas in Pregnancies Complicated by Preeclampsia, Diabetes and Preeclampsia and Diabetes

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