Association among serum cortisol, dehydroepiandrosterone-sulfate levels and psychiatric symptoms in men with chronic schizophrenia

Peng, Rui; Li, Yan

doi:10.1016/j.comppsych.2017.03.011

Cited by 13 publications

(12 citation statements)

References 21 publications

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“…Our results indicated the serum level of cortisol in CSZ patients was significantly lower than that in the FES group or in the HC group ( P < 0.05). This concurs with other researches ( 22 , 25 – 28 ). Rui Peng, et al.…”

Section: Discussionsupporting

confidence: 94%

“…However, another study showed that atypical antipsychotic treatment could contribute to increase serum levels of the cortisol ( 29 ). In addition, our findings also showed no significant difference in serum cortisol levels between the FES and HC groups ( P > 0.05), which is consistent with previous researches ( 24 , 30 , 31 ), while some findings showed that CSZ patients had higher cortisol concentration ( 22 , 29 ) or no elevated diurnal cortisol level in antipsychotic-naive, putatively at-risk children who present multiple antecedents of SZ or a family history of illness ( 23 ). Furthermore, dysfunctional HPA axis activities with reduced cortisol decline have been associated with poorer cognitive performance and memory deficits ( 25 ), poorer chronic response to daily stressors (failure to dampen during the day) ( 26 ), activation of dysfunctional dopamine pathways, and greater symptom severity ( 27 , 28 ) in SZ patients.…”

Section: Discussionsupporting

confidence: 92%

“…Rui Peng, et al. ( 22 ) reported that atypical antipsychotics could suppress the HPA axis activity by lowering cortisol levels in serum based on the measured levels between before and after treatment. However, another study showed that atypical antipsychotic treatment could contribute to increase serum levels of the cortisol ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

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Altered Expression of Glucocorticoid Receptor and Neuron-Specific Enolase mRNA in Peripheral Blood in First-Episode Schizophrenia and Chronic Schizophrenia

Liu

Tang

et al. 2020

Front. Psychiatry

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Introduction It is well-known that altered hypothalamus–pituitary–adrenal (HPA) axis process has an important role in the neurodegenerative process in schizophrenia (SZ). However, this neurodegenerative mechanism has not been clarified in SZ. Therefore, the main purpose of this study was to determine HPA axis damage in the first-episode, unmedicated schizophrenia (FES) patients and chronic schizophrenia (CSZ) patients in comparison with healthy controls (HC) by means of quantitative analysis of the peripheral blood mRNA expression of glucocorticoid receptor (GR), GR transcripts containing exons 1B (GR-1B), and neuron specific enolase (NSE) genes and serum cortisol and NSE, a specific serum marker for neuronal damage. Methods In the present study, 43 FES patients, 39 CSZ, and 47 HC were included. The peripheral blood mRNA expressions for GR, GR-1B, and NSE genes were determined by real-time quantitative polymerase chain reaction (RT-qPCR). Serum cortisol and NSE were analyzed by electrochemiluminescence immunoassay technique. Results Levels of GR mRNA were significantly lower in FES and CSZ than that in HC. The expression of GR-1B mRNA was significantly decreased in CSZ when compared with that in FES. Levels of NSE mRNA were significantly lower in CSZ than that in FES patients or HC patients. CSZ patients showed significantly lower cortisol concentrations than FES and HC patients. FES patients showed significantly higher NSE concentrations than CSZ and HC. Conclusion Our findings support that there is disrupted HPA axis system in the SZ and suggest that CSZ patients suffer a greater HPA axis damage than FES patients. Our research implicated underlying GR mRNA dysregulation in SZ and the potential importance of the functional GR-1B transcription in CSZ.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

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Altered Expression of Glucocorticoid Receptor and Neuron-Specific Enolase mRNA in Peripheral Blood in First-Episode Schizophrenia and Chronic Schizophrenia

Liu

Tang

et al. 2020

Front. Psychiatry

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“… 22 , 23 The authors specifically insist that the determination of afternoon cortisol levels may serve to detect potential candidates for specific cognitive intervention in the patients immediately after the first psychotic breakthrough. 22 – 24 …”

Section: Discussionmentioning

confidence: 99%

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

et al. 2021

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Background: Hypothalamic–pituitary–adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology of schizophrenia. Objective: We examined the association of serum cortisol with disease severity and improvement in schizophrenia patients in Jimma, Ethiopia. Method: A total of 34 newly diagnosed schizophrenics were included in this study. Data on demographic, behavioral, clinical state, serum cholesterol level, and antipsychotic usage were obtained at baseline and after 8 weeks. The Positive and Negative Syndrome Scale was used to assess psychotic symptoms severity. A paired sample t-test was used to compare baseline and post-treatment values. Linear regression was used to assess associations. Result: Post-treatment serum cortisol level was significantly lower than its baseline value ( p = 0.001). There was also a significant positive and negative psychotic symptoms decrease after treatment (baseline positive psychotic vs post-treatment positive psychotic symptoms: t(33) = 6.24 (95% confidence interval = 7.03,13.84, p = 0.000) and (baseline negative psychotic vs post-treatment negative psychotic symptoms: t(33) = 4.21 (95% confidence interval = 3.82, 10.99, p = 0.000). At baseline, neither positive nor negative subscore on the Positive and Negative Syndrome Scale showed an association with serum cortisol level ( B = −0.016, p = 0.794 and B = −0.032, p = 0.594). However, serum cortisol level showed strong associations with post-treatment positive sub scores and negative sub scores ( B = 0.167, p = 0.007) and ( B = 0.144, p = 0.010) on the Positive and Negative Syndrome Scale. Conclusion: We found a significant decrease in serum cortisol level after antipsychotics treatment and that was associated with improvement in psychotic symptoms in schizophrenics in Jimma, Ethiopia.

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“…Cortisol level may also impact a symptomatic severity. It has been reported that increased salivary cortisol level positively correlates with negative symptoms severity [44]. Positive and disorganized symptoms have been found to be greater in patients with higher basal cortisol level [43].…”

Section: Hpa Axis In Schizophreniamentioning

confidence: 98%

The role of the interaction between the FKBP5 gene and stressful life events in the pathophysiology of schizophrenia: A narrative review

Stramecki¹,

Frydecka²,

Misiak³

2020

Arch Psych Psych

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Stressful life events have been associated with increased risk for development of schizophrenia and play a pivotal role in its psychopathology. Genes related to stress response, such as FKBP5 gene associated with hypothalamic-pituitary-adrenal (HPA) axis, modulate brain response to childhood trauma and determine individual susceptibility for development and course of psychosis. It this review we provide an overview of FKBP5 gene role in human neurophysiology, its association with HPA axis and its role in stress response system in animals and humans. Moreover, we took a closer look on the studies showing the interaction between FKBP5 gene and stressful life events in the pathophysiology of schizophrenia. We explain how interactions between trauma and FKBP5 gene polymorphisms contribute to development of the disease, severity of psychotic symptoms and cognitive disturbances. We also discuss epigenetic modifications that may contribute to altered HPA axis reactivity to stress entailing higher risk for development of psychosis. Considering the pivotal role of FKBP5 gene in physiopathology of schizophrenia we discuss a possible use of new therapeutic agents that may influence HPA axis activity related to the FKBP5 protein especially in individuals exposed to early trauma.

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Association among serum cortisol, dehydroepiandrosterone-sulfate levels and psychiatric symptoms in men with chronic schizophrenia

Cited by 13 publications

References 21 publications

Altered Expression of Glucocorticoid Receptor and Neuron-Specific Enolase mRNA in Peripheral Blood in First-Episode Schizophrenia and Chronic Schizophrenia

Altered Expression of Glucocorticoid Receptor and Neuron-Specific Enolase mRNA in Peripheral Blood in First-Episode Schizophrenia and Chronic Schizophrenia

The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

The role of the interaction between the FKBP5 gene and stressful life events in the pathophysiology of schizophrenia: A narrative review

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