Association Among Serum Perfluoroalkyl Chemicals, Glucose Homeostasis, and Metabolic Syndrome in Adolescents and Adults

Lin, Chien‐Yu; Chen, Pau‐Chung; Lin, Yu-Tsan; Lin, Lian‐Yu

doi:10.2337/dc08-1816

Cited by 238 publications

(183 citation statements)

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“…They also found that there was no difference in PFOS levels between those taking and not taking medication. Sensitivity analyses of those on cholesterol lowering medication did not impact the effect estimates (Château-Degat et al, 2010;Lin et al, 2009;Sakr et al, 2007a, b). In addition, the removal of participants using cholesterol lowering medication may bias the results by removing the diseased participants and leaving those with untreated high cholesterol.…”

Section: Discussionmentioning

confidence: 96%

“…Nelson et al (2010) reported that people in the highest PFOA quartile had TC levels 0.36 mmol/L higher than those in the lowest quartile. Lin et al (2009) investigated the relationship between PFAAs and components of metabolic syndrome using NHANES data and found that increased serum PFNA concentrations are associated with a lower prevalence of HDLC below the criteria. Our results for PFNA were consistent with Nelson's study; people in the highest PFNA quartile had ln-TC and ln-LDLC levels 0.25 and 0.33 mmol/L higher than those in the lowest quartile, respectively (Nelson et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tPerfluoroalkyl acids (PFAAs) have been used in a variety of products for many years and have been detected worldwide in human serum. Previous studies have suggested the potential effects of PFAAs on serum lipids. To investigate the associations between serum concentrations of PFAAs and serum lipid levels, 133 participants were randomly selected from the people coming for health check-up in Yuanyang Red Cross Hospital of Henan, China. Linear regression analysis revealed that perfluoro-octanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), with a median concentration of 1.43, 0.37, and 0.19 ng/mL, respectively, were positively associated with total cholesterol (TC). Those in the highest quartile of PFOA exposure had ln-TC levels 0.24 mmol/L higher than those in the lowest quartile. For PFNA and PFDA, effect estimates were 0.25 and 0.16 mmol/L, respectively. A positive association between high-density lipoprotein cholesterol (HDLC) and PFDA was found, and there was a 0.18 mmol/L increase of HDLC for the top PFDA quartile compared with the lowest quartile. PFOA and PFNA were positively associated with low-density lipoprotein cholesterol (LDLC). Ln-LDLC levels of people in both top PFOA and PFNA quartiles were 0.33 mmol/L higher than those in the lowest quartiles. Logistic regression analysis indicated that increased PFOA and PFOS quartiles were positively associated with an increased risk of abnormal TC and LDLC when controlling for no confounding factors.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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“…First, evidence has shown associations between MetS and selected environmentally hazardous materials, with difference noted in the associations by sex. For example, previous studies reported that serum perfluoroalky chemicals (PFCs), a class of human-made organic chemicals, were associated with glucose homeostasis and indicators of MetS, 29 and several studies have reported the sex-specific toxicity after exposed to PFCs. 30,31 Experimental studies showed that the biological half-life of PFCs in male rats is 70 times longer than in female rats, and the difference is mainly attributed to a difference in renal clearance [CL(R)].…”

Section: Discussionmentioning

confidence: 99%

Sex difference in the prevalence of metabolic syndrome and cardiovascular-related risk factors in urban adults from 33 communities of China: The CHPSNE study

Song

Zhao

Liu

et al. 2015

Diabetes and Vascular Disease Research

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Little is known about the epidemiology of metabolic syndrome in urban areas of China. To estimate the prevalence of MetS and identify its cardiovascular-related factors in men and women, a representative sample of 15,477 urban adults aged 18-74 years in Northeast China was selected from 2009 to 2010. The diagnosis of metabolic syndrome was based on criteria set by the National Cholesterol Education Program/Adult Treatment Panel. The overall prevalence of metabolic syndrome was 27.4% (men 27.9% and women 26.8%). Multivariable logistic regression analysis revealed that a higher education level and a higher family income were associated with a higher prevalence of metabolic syndrome in men, but associated with lower prevalence of metabolic syndrome among women. Higher physical activity was associated with a decreased prevalence of metabolic syndrome in men (adjusted odds ratios (aORs) = 0.88, 95% confidence interval (CI): 0.79-0.99), but associated with an increased prevalence of metabolic syndrome in women (aOR = 1.14, 95% CI: 1.00-1.29). Compared with rice as the major staple food, cooked wheaten foods were associated with lower adjusted odds for metabolic syndrome both in men (aOR = 0.72, 95% CI: 0.58-0.90) and in women (aOR = 0.72, 95% CI: 0.56-0.92). In conclusion, metabolic syndrome is highly prevalent in urban areas of China, and there is heterogeneity by sex in the relationships between risk factors and metabolic syndrome prevalence.

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“…In rats, fasted serum glucose was not affected by 0.5 or 1.5 mg/kg PFOS, although 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 33 insulin and leptin were increased (Lv et al, 2013). In a human study, PFOA and PFOS concentrations were negatively associated with serum glucose levels both in adolescents and adults, but not statistically significant (Lin et al, 2009). However, associations between PFOA or PFOS and various parameters linked to metabolic syndrome were significant.…”

Section: Determination Of Internal Doses Of Pfoa and Pfosmentioning

confidence: 95%

In utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice

Ngo

Hetland

Sabaredzovic

et al. 2014

Environmental Research

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We examined whether perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) had obesogenic effects and if they increased spontaneous intestinal tumorigenesis in the mouse model C57BL/6J-Min/+ (multiple intestinal neoplasia) after in utero exposure. The dams were exposed to PFOA or PFOS (0.01, 0.1 or 3.0 mg/kg bw/day) by po gavage on GD1-17. TheMin/+ and wild-type offspring were terminated at week 11 for examination of intestinal tumorigenesis or at week 20 for obesogenic effect, respectively. Body weights of the dams and pups were recorded throughout life. Food intake was determined at week 6 and 10. Blood glucose (non-fasted) was measured at week 6 and 11. No obesogenic effect of PFOA or PFOS was observed up to 20 weeks of age. PFOA or PFOS did not increase the incidence or number of tumors in the small intestine or colon of the Min/+ mice or affect their location along the intestines. Feed intake was not affected. There were some indications of toxicity of PFOA, but not of PFOS. There was lower survival of pups after 3.0 mg/kg PFOA, lower body weight in pups after 3.0 and possibly 0.1 mg/kg PFOA, and increased relative liver weight after 0.01 and possibly 0.1 mg/kg PFOA. Plasma glucose was lower after 0.01 and 0.1 mg/kg PFOA. In conclusion, exposure to PFOA and PFOS in utero with the doses used did not have obesogenic effect on either Min/+ or wild-type mice, at least not up to 11 or 20 weeks of age, nor increased intestinal tumorigenesis in Min/+ mice.

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Association Among Serum Perfluoroalkyl Chemicals, Glucose Homeostasis, and Metabolic Syndrome in Adolescents and Adults

Abstract: OBJECTIVE -Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known. RESEARCH DESIGN AND METHODS

Cited by 238 publications

References 23 publications

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Sex difference in the prevalence of metabolic syndrome and cardiovascular-related risk factors in urban adults from 33 communities of China: The CHPSNE study

In utero exposure to perfluorooctanoate (PFOA) or perfluorooctane sulfonate (PFOS) did not increase body weight or intestinal tumorigenesis in multiple intestinal neoplasia (Min/+) mice

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