Association among the prognostic nutritional index, completion of adjuvant chemotherapy, and cancer-specific survival after curative resection of stage II/III gastric cancer

Xiao, Hua; Zhou, Huijun; Zhang, Peng; Xiao, Huang; Liu, Ke; Chen, Xiaoyan; Hu, Quan; Yin, Bin; Li, Rongrong; Huang, Gang; Yin, Xi; Ouyang, Yongzhong

doi:10.1038/s41430-019-0502-1

Cited by 21 publications

(33 citation statements)

References 36 publications

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“…Recently, Yuming Jiang et al 8 reported some prognostic risk factors and tried to predict the survival benefit of adjuvant chemotherapy for patients with stage II and stage III gastric cancer, but no subgroup analysis was carried out in their study. In addition, although many studies have identified a series of prognostic factors related to gastric cancer [19][20][21] , none of the studies discussed stage II gastric cancer separately. Thus, in our study, we attempted to use some available and typical clinicopathological factors and identify their effects on the survival of stage II gastric cancer patients, with the aim to build a model for selecting patients with stage II gastric cancer who can benefit from adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Survival Analysis of Stage II Gastric Cancer Patients after D2 Gastrectomy: A Chinese People-based Research Running Head: Survival of Stage II Gastric Cancer

Deng

Lü

Chen

et al. 2021

Preprint

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Objective: The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients.Methods: We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007-2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center. Propensity score matching (PSM) was used to ensure that the baseline data were balanced between the adjuvant chemotherapy (AC) group and surgery-only group. Kaplan-Meier survival and multivariate Cox regression analyses were carried out to identify independent prognostic factors. Results: In univariate analysis, after propensity score matching, age, tumor location, tumor size, CEA, T stage and N stage were associated with overall survival (OS). Multivariate analysis illustrated that age ≥60 years old, linitis plastica and T4 were independent risk factors for OS, but lower location and adjuvant chemotherapy were protective factors. Conclusion: Adjuvant chemotherapy is helpful for stage II gastric cancer patients. These prognostic factors can help guide individual therapy.

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Section: Discussionmentioning

confidence: 99%

Survival Analysis of Stage II Gastric Cancer Patients after D2 Gastrectomy: A Chinese People-based Research Running Head: Survival of Stage II Gastric Cancer

Deng

Lü

Chen

et al. 2021

Preprint

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“…It should be noted that the incompletion of adjuvant chemotherapy was identified as an independent risk factor for poor cancer-specific survival in gastric cancer patients in a previous study. 27 In total gastrectomy for Siewert type II AEG, a sufficient proximal margin should be ensured with curative intent. The proximal margin is crucial for the resection status and therefore associated with the long-term survival of cancer patients.…”

Section: Figurementioning

confidence: 99%

<p>Short-Term and Long-Term Outcomes Following Transhiatal versus Right Thoracoabdominal Resection of Siewert Type II Adenocarcinoma of the Esophagogastric Junction</p>

Xing

Liu

et al. 2020

CMAR

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“…Current nutritional research on gastric cancer patients has included the relationship between nutrition and quality of life [ 20 ], the efficacy of nutritional assessment tools for predicting complications [ 21 , 22 ], and postoperative changes in nutritional intake [ 23 , 24 ]. Nevertheless, there are very few studies on the dietary factors that influence the weight loss of patients over an extended time period, for both domestic and overseas patients.…”

Section: Introductionmentioning

confidence: 99%

Nutritional and Clinical Factors Affecting Weight and Fat-Free Mass Loss after Gastrectomy in Patients with Gastric Cancer

et al. 2020

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After a gastrectomy, the nutritional status of patients with gastric cancer has great effect on the treatment outcome and patients’ quality of life. We investigated the changes in body composition and nutrient intake after gastrectomy in 288 gastric cancer patients. A multiple linear regression analysis was used for each time period to verify the effects of nutritional and clinical factors on weight and fat-free mass loss rates. Gastric cancer patients who underwent a gastrectomy continued to experience weight and fat-free mass loss until three months after surgery and became stagnant at six months. The marginal mean of calorie intake per weight was 24.5, 26.8, and 29.4 kcal at one, three, and six months. The protein intake per kg lean mass was 1.14, 1.14, and 1.16 g at one, three, and six months, respectively. One month after surgery, the rate of weight loss increased significantly in females who received chemotherapy (p < 0.001). At one to three months postoperative, females who had undergone chemotherapy tended to significantly lose weight (p = 0.016). Females with a history of chemotherapy also showed a reduction in fat-free mass for one to three months (p = 0.036). Calorie intake was a significant factor in preventing fat-free mass weight loss at one month after surgery. Chemotherapy was an independent factor affecting the weight and fat-free mass loss rate up to six months after gastrectomy. Careful monitoring of weight and muscle mass changes following active nutritional intervention for sufficient nutrition support could be helpful for patients after gastrectomy.

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Association among the prognostic nutritional index, completion of adjuvant chemotherapy, and cancer-specific survival after curative resection of stage II/III gastric cancer

Cited by 21 publications

References 36 publications

Survival Analysis of Stage II Gastric Cancer Patients after D2 Gastrectomy: A Chinese People-based Research Running Head: Survival of Stage II Gastric Cancer

Survival Analysis of Stage II Gastric Cancer Patients after D2 Gastrectomy: A Chinese People-based Research Running Head: Survival of Stage II Gastric Cancer

<p>Short-Term and Long-Term Outcomes Following Transhiatal versus Right Thoracoabdominal Resection of Siewert Type II Adenocarcinoma of the Esophagogastric Junction</p>

Nutritional and Clinical Factors Affecting Weight and Fat-Free Mass Loss after Gastrectomy in Patients with Gastric Cancer

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