Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

Abstract

Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms.However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants.

Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents

“…41,42 In Egypt, however, no risk was found between obesity and rs9939609 in 200 children and adolescents. 43 In a New Zealand-based study, no significant difference was found between BMI z-score and FTO-rs9939609 and MC4R-rs17782313 and between body fat percentage and FTO-rs1421085 in European children. 44 In a study involving 580 children in Mexico, a positive relationship was found between blood pressure and rs9939609, rs17782313, while no significant correlation was found between total cholesterol and HDL cholesterol.…”

ASSESSMENT OAF -243A>G POLYMORPHISM OF GLUTAMATE DECARBOXYLASE 2 GENE IN OBESE PATIENTS

“…The disease is highly prevalent in Egypt with an estimated prevalence of approximately 61-70% of the adult population with a higher percentage in females more than males. Obesity is also considered as one of the top contributors to mortality among Egyptians due to the associated comorbid diseases as hypertension and diabetes (6) .…”

<p>The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population</p>

“…No association with obesity phenotype in Egyptian adolescents and children; however, the presence of the risk allele was linked to higher LDL cholesterol (n=200) 42…”

“… Neuropeptide Y ( NPY ) 7q15.1This peptide regulates energy homeostasis thought binds to its receptor on PVN .rs53587023717-bp deletion at 5’UTR0.00039Observed in one Mexican American family (n=934) 58 Fat Mass Obesity-Associated gene ( FTO ) 16q12.2Demethylation enzyme involved in controlling of energy homeostasis, DNA methylation and abiogenesisrs9939609Intron 10.340No association with obesity phenotype in Egyptian adolescents and children; however, the presence of the risk allele was linked to higher LDL cholesterol (n=200) 42Associated with morbid obesity risk in the Brazilian adults (n=239) and Mexican population (n=1,156) 13,44…”