Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents

Yaşar, Adem

doi:10.1055/s-0040-1713154

Cited by 9 publications

(8 citation statements)

References 49 publications

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“…In our results, variant rs1421085 was found to be associated with high consumption of Kcal, and mean differences were observed in the percentage of body fat. This marker has been extensively studied, and recent studies have found higher allelic frequencies in people with obesity as well as its associations with higher triglyceride and cholesterol levels in Turkish children [31]. Likewise, rs1421085 was previously reported with higher allelic frequencies in the Iranian population, showing its association with obesity markers [32].…”

Section: Discussionmentioning

confidence: 84%

Identification and Association of Single Nucleotide Polymorphisms of the FTO Gene with Indicators of Overweight and Obesity in a Young Mexican Population

Chama-Avilés

Flores-Viveros

Cabrera-Ayala

et al. 2023

Genes

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(1) Background: obesity is a global public health problem; various factors have been associated with this disease, and genetic factors play a very important role. Previous studies in multiple populations have associated a gene with fat mass and obesity (FTO). Thus, the present work aims to identify and determine associations between genetic variants of FTO with indicators of overweight and obesity in the Mexican population. (2) Methods: a total of 638 subjects were evaluated to compile data on body mass index (BMI), the percentage of body fat (%BF), the waist circumference (WC), the serum levels of triglycerides (TG), and food consumption. A total of 175 genetic variants in the FTO gene were sampled by a microarray in the evaluated population, followed by association statistical analyses and comparisons of means. (3) Results: a total of 34 genetic variants were associated with any of the 6 indicators of overweight and obesity, but only 15 showed mean differences using the recessive model after the Bonferroni correction. The present study shows a wide evaluation of FTO genetic variants associated with a classic indicator of overweight and obesity, which highlights the importance of genetic analyses in the study of obesity.

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Section: Discussionmentioning

confidence: 84%

Identification and Association of Single Nucleotide Polymorphisms of the FTO Gene with Indicators of Overweight and Obesity in a Young Mexican Population

Chama-Avilés

Flores-Viveros

Cabrera-Ayala

et al. 2023

Genes

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“…По данным нашего исследования, в общей группе обнаружена ассоциация с содержанием ХС ЛПНП (наименьший уровень ХС ЛПНПу носителей генотипа АТ, достоверно больший -у подростков с генотипом АТ). У молодых людей 25-35 лет из популяции города Новосибирска самая высокая концентрация ХС ЛПНП также наблюдалась у носителей генотипа АА [7], тогда как у детей в Турции rs9939609 ассоциирован с ХС ЛПВП и ТГ [4]. Кроме того, статистически значимые различия у носителей разных генотипов rs9939609 гена FTO выявлены по средней толщине кожной складки в средней трети правого плеча (р = 0,049; наибольшая при генотипе АА) у девочек.…”

Section: Discussionunclassified

“…Число детей и подростков с ожирением за последние 20 лет увеличилось в 2 раза. Важным фактором риска его развития является генетическая предрасположенность [1][2][3][4]. В онлайн-каталоге генов и генетических заболеваний человека OMIM (Online Mendelian Inheritance in Man) при поиске по ключевому слову «obesity» находится 738 записей [5].…”

Section: Introductionunclassified

Associations of polymorphisms of some genes with cardiometabolic risk factors in adolescents from Novosibirsk

Денисова

Gurazheva

Максимов

2023

jour

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Aim of the study was to investigate the association of polymorphisms of some genes with overweight and certain anthropometric and biochemical parameters in a population sample of adolescents in Novosibirsk. Material and methods. In 2019, a population-based screening of a representative sample of adolescents (609 people) was carried out in Novosibirsk. All children and their parents signed an informed consent for the examination. The study was approved by the local Ethics Committee of the Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS. During the examination, a questionnaire was filled out, anthropometric measurements were carried out, blood sampling was carried out, followed by a biochemical study. 157 people (75 boys (47.8 %), 82 girls (52.2 %)) were selected for molecular genetic analysis using tables of random numbers. The weight status of adolescents was assessed using the IOTF (International Obesity Task Force) criteria. The subsequent analysis compared 2 groups: 1st group included teenagers with weight deficiency and normal body weight), the 2nd – with overweight, obesity and extreme obesity). Results. In the general group, differences in carriers of different genotypes of the rs9939609 FTO gene were found in the level of low-density lipoprotein cholesterol (LDL-C) (p = 0,024). The girls with the AA rs9939609 genotype had the greatest average thickness of the skin fold in the middle third of the right shoulder. Differences were found in carriers of different genotypes rs7903146 of TCF7L2 gene in the average fasting plasma glucose (FPG) level (p = 0,021). The average thickness of the skin fold in the middle third of the right shoulder was greater in girls carrying the CC genotype compared with carriers of the CT and TT genotypes (p = 0,041). In separate subgroups, in carriers of different genotypes of rs10811661 CDKN2AB gene were found differences in high-density lipoprotein cholesterol, FPN, and waist circumference, in nucleotide sequence variant (NSV) rs2237892 KCNQ1 gene carriers – in triglyceride, FPG, LDL-C and total cholesterol concentration, in rs1111875 HHEX gene carriers – in total cholesterol, LDL-C level, waist and hip circumference, thickness of the skin fold under the scapula, diastolic blood pressure. Conclusions. Associations of the studied NSV (rs9939609, rs7903146, rs10811661, rs2237892, rs1111875) were found in the group as a whole and in separate subgroups (with division by body mass index, gender), with anthropometric and biochemical parameters, such as total cholesterol, triglyceride, LDL-C, FPN content, diastolic blood pressure, waist and hip circumferences, thickness of the skin fold under the scapula and in the middle third of the right shoulder. There were no statistically significant differences in the frequencies of studied NVS genotypes and alleles between the 1st and 2nd groups.

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“…They also suggested the possibility of an allele-dependent effect of the rs9939609 polymorphism on serum TG levels. Inandiklioğlu et al demonstrated that the serum TG levels increased with the TT, TA, and AA genotypes of the rs9939609 polymorphism in a group of obese Turkish children and adolescents aged 3–17 years, in that order (1.21 vs. 1.37 vs. 1.89 mmol/L, p = 0.004) [ 127 ]. A similar finding was obtained in a study on a group of south Brazilian children and adolescents [ 53 ].…”

Section: Some Genetic Polymorphisms Of Fto Increas...mentioning

confidence: 99%

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

et al. 2023

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Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphisms in intron 1, such as rs9939609 and rs9930506 polymorphisms, are significantly associated with the development of MetS in children and adolescents. Mechanistic studies reported that FTO polymorphisms lead to aberrant expressions of FTO and the adjacent genes that promote adipogenesis and appetite and reduce steatolysis, satiety, and energy expenditure in the carriers. The present review highlights the recent observations on the key FTO polymorphisms that are associated with child and adolescent MetS with an exploration of the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia in child and adolescent MetS.

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Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents

Cited by 9 publications

References 49 publications

Identification and Association of Single Nucleotide Polymorphisms of the FTO Gene with Indicators of Overweight and Obesity in a Young Mexican Population

Identification and Association of Single Nucleotide Polymorphisms of the FTO Gene with Indicators of Overweight and Obesity in a Young Mexican Population

Associations of polymorphisms of some genes with cardiometabolic risk factors in adolescents from Novosibirsk

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

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